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Documenta Ophthalmologica

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27.10.2018 | Original Research Article

Evaluating the neuroprotective effect of 17β-estradiol in rodent models of oxidative retinopathies

verfasst von: Samaneh Chaychi, Anna Polosa, Sylvain Chemtob, Pierre Lachapelle

Erschienen in: Documenta Ophthalmologica | Ausgabe 3/2018

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Abstract

Purpose

To determine the neuroprotective effect of estrogen on the structure and function of the retina exposed to an oxidative stress.

Methods

Male Sprague–Dawley rat pups were exposed to either hyperoxia (O₂E: from P8 to P14) or bright light (LE: from P14 to P28) with or without 17 β-estradiol (βE₂) treatment. Retinal structure (histology) and function (ERG) were assessed at selected time points.

Results

In the O₂E model, βE₂ injections caused a significant reduction of the ERG and a significantly thinner OPL compared to untreated oxygen-exposed group (O₂-exposed) rats. In contrast, in the LE model βE₂, treatment was beneficial to the retinal structure (thicker ONL) and function (better preserved ERG amplitudes) compared to untreated light-exposed group (light-exposed rats).

Conclusion

Our results show that in conditions where the primary target of the oxidative stress is the outer retina (i.e., the photoreceptors) estrogen can protect the retina, while in situations where the inner retina (or retinal vasculature) is the main site of oxidative damage, estrogen may potentiate the detrimental effect of oxidative stress on the retina.

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Titel: Evaluating the neuroprotective effect of 17β-estradiol in rodent models of oxidative retinopathies
verfasst von: Samaneh Chaychi
Anna Polosa
Sylvain Chemtob
Pierre Lachapelle
Publikationsdatum: 27.10.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: Documenta Ophthalmologica / Ausgabe 3/2018
Print ISSN: 0012-4486
Elektronische ISSN: 1573-2622
DOI: https://doi.org/10.1007/s10633-018-9658-6

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Evaluating the neuroprotective effect of 17β-estradiol in rodent models of oxidative retinopathies

Abstract

Purpose

Methods

Results

Conclusion

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Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

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Abstract

Purpose

Methods

Results

Conclusion

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