Evaluation of Diagnostic Significance of Salivary miRNA-184 and miRNA-21 in Oral Squamous Cell Carcinoma and Oral Potentially Malignant Disorders
- 28.11.2023
- Research
Erschienen in:
- Verfasst von
- Aarushi Garg
- Aadithya B. Urs
- Bidhan Chandra Koner
- Jeyaseelan Augustine
- Sameer Ahmad Guru
- Erschienen in
- Head and Neck Pathology | Ausgabe 4/2023
Abstract
Background
Altered levels of miRNAs might affect the pathogenesis of oral squamous cell carcinoma (OSCC) and oral potentially malignant disorders (OPMD). This study evaluated the diagnostic potential of salivary miRNA-21 and miRNA-184 in OSCC and OPMD.
Methods
We recruited a total of 90 subjects including OSCC, OPMD, and healthy controls. RNA was isolated from the saliva samples of the study subjects. Expression of miRNA-21 and miRNA-184 was analyzed using qRT-PCR. Their levels were compared and the diagnostic cut-off was determined using the ROC curve.
Results
There was a significant increase in miRNA-21 and a decrease in miRNA-184 in OSCC and OPMD as compared to healthy controls (p < 0.001). Levels of salivary miRNA-21 and miRNA-184 can differentiate OSCC and OPMD from controls and premalignant conditions from malignant conditions.
Conclusion
Salivary miRNA-21 and miRNA-184 may be beneficial for the early detection of OSCC and OPMD. Also, saliva can be used for detecting neoplastic transformation of oral mucosa since it is non-invasive and easily accessible.
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- Titel
- Evaluation of Diagnostic Significance of Salivary miRNA-184 and miRNA-21 in Oral Squamous Cell Carcinoma and Oral Potentially Malignant Disorders
- Verfasst von
-
Aarushi Garg
Aadithya B. Urs
Bidhan Chandra Koner
Jeyaseelan Augustine
Sameer Ahmad Guru
- Publikationsdatum
- 28.11.2023
- Verlag
- Springer US
- Erschienen in
-
Head and Neck Pathology / Ausgabe 4/2023
Elektronische ISSN: 1936-0568 - DOI
- https://doi.org/10.1007/s12105-023-01600-7
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