Evaluation of in vitro growth and pathogenicity in mice of intra-genotype chimeric strains of genotype IV Japanese encephalitis virus
- 01.06.2025
- Brief Report
- Verfasst von
- Shigeru Tajima
- Astri Nur Faizah
- Daisuke Kobayashi
- Kris Cahyo Mulyatno
- Sri Subekti
- Maria Inge Lusida
- Yasuko Mori
- Haruhiko Isawa
- Kyoko Sawabe
- Chang-Kweng Lim
- Erschienen in
- Archives of Virology | Ausgabe 6/2025
Abstract
Two recombinant intra-genotype chimeric genotype IV Japanese encephalitis virus (GIV JEV) strains with the 5’ non-coding and C-prM-E regions (5NCME) of the Vietnamese strain VN113 or the Australian strain sw-22-00722-11.Qld (sw-22) were produced using the Indonesian strain 19CxBa-83-Cv as a backbone. The three strains exhibited similar plaque morphology and growth rate in Vero cells. The virus with sw-22 5NCME was less neuroinvasive than 19CxBa-83-Cv, but the virulence of the virus with VN113 5NCME was similar to that of 19CxBa-83-Cv. Thus, our results suggest that the pathogenicity of sw-22 might be lower than that of the other two GIV JEV isolates.
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- Titel
- Evaluation of in vitro growth and pathogenicity in mice of intra-genotype chimeric strains of genotype IV Japanese encephalitis virus
- Verfasst von
-
Shigeru Tajima
Astri Nur Faizah
Daisuke Kobayashi
Kris Cahyo Mulyatno
Sri Subekti
Maria Inge Lusida
Yasuko Mori
Haruhiko Isawa
Kyoko Sawabe
Chang-Kweng Lim
- Publikationsdatum
- 01.06.2025
- Verlag
- Springer Vienna
- Erschienen in
-
Archives of Virology / Ausgabe 6/2025
Print ISSN: 0304-8608
Elektronische ISSN: 1432-8798 - DOI
- https://doi.org/10.1007/s00705-025-06317-2
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