Skip to main content
Erschienen in: Comparative Clinical Pathology 2/2018

08.12.2017 | Original Article

Evaluation of lipid-lowering effect of Cynara scolymus extract-loaded mesoporous silica nanoparticles on ultra-lipid-fed mice

verfasst von: Amir Asadabadi Safat, Hassan Sheibani, Pourya Mohammadi, Navid Hasanabadi, Ehsanollah Sakhaee

Erschienen in: Comparative Clinical Pathology | Ausgabe 2/2018

Einloggen, um Zugang zu erhalten

Abstract

In current investigation, twenty mice were divided into 4 different equal groups as follows: group CS which received 0.1 ml Cynara scolymus extract (diluted in distilled water) at dose of 600 mg kg−1 daily for 3 weeks, group A which received 0.1 ml Atorvastatin 40 (diluted in distilled water) at dose of 20 mg kg−1 daily for 21 days, group T which received 0.1 ml of Cynara scolymus extract at dose of 600 mg kg−1 daily in nonporous (diluted in distilled water) during experimental period, and control group (group C) which received the same volume of normal saline. The supplements were gavaged in all animals, during experiment period, and blood samples were obtained after 21 days. Results showed that total cholesterol and triglyceride decreased significantly in the treatment group compared with the control and CS groups (p < 0.05). It seems that mesoporous silica nanoparticles improve drug delivery and therefore Cynara scolymus extract-loaded mesoporous silica nanoparticles has more effective lipid-lowering action than Cynara scolymus extract.
Literatur
Zurück zum Zitat Chaudhary A, Nagaich U, Gulati N, Sharma V, Khosa R, Partapur MU (2012) Enhancement of solubilization and bioavailability of poorly soluble drugs by physical and chemical modifications: a recent review. J Adv Pharm Educ Res 2:32–67 Chaudhary A, Nagaich U, Gulati N, Sharma V, Khosa R, Partapur MU (2012) Enhancement of solubilization and bioavailability of poorly soluble drugs by physical and chemical modifications: a recent review. J Adv Pharm Educ Res 2:32–67
Zurück zum Zitat Chen Y et al (2009) Hollow/rattle-type mesoporous nanostructures by a structural difference-based selective etching strategy. ACS Nano 4:529–539CrossRef Chen Y et al (2009) Hollow/rattle-type mesoporous nanostructures by a structural difference-based selective etching strategy. ACS Nano 4:529–539CrossRef
Zurück zum Zitat CONSULTATION E (2008) Committee on herbal medicinal products (HMPC) CONSULTATION E (2008) Committee on herbal medicinal products (HMPC)
Zurück zum Zitat Dahlöf B (2010) Cardiovascular disease risk factors: epidemiology and risk assessment. Am J Cardiol 105:3A–9ACrossRefPubMed Dahlöf B (2010) Cardiovascular disease risk factors: epidemiology and risk assessment. Am J Cardiol 105:3A–9ACrossRefPubMed
Zurück zum Zitat Javadzadeh Y, Mohammadi A, Khoei NS, Nokhodchi A (2009) Improvement of physicomechanical properties of carbamazepine by recrystallization at different pH values. Acta Pharma 59:187–197CrossRef Javadzadeh Y, Mohammadi A, Khoei NS, Nokhodchi A (2009) Improvement of physicomechanical properties of carbamazepine by recrystallization at different pH values. Acta Pharma 59:187–197CrossRef
Zurück zum Zitat Khalil R, Abuharfeil N, Shabsoug B (2008) The effect of Crataegus aronica aqueous extract in rabbits fed with high cholesterol diet. Eur J Sci Res 22:352–360 Khalil R, Abuharfeil N, Shabsoug B (2008) The effect of Crataegus aronica aqueous extract in rabbits fed with high cholesterol diet. Eur J Sci Res 22:352–360
Zurück zum Zitat Mulvihill EE, Huff MW (2010) Antiatherogenic properties of flavonoids: implications for cardiovascular health. Can J Cardiol 26:17A–21ACrossRefPubMed Mulvihill EE, Huff MW (2010) Antiatherogenic properties of flavonoids: implications for cardiovascular health. Can J Cardiol 26:17A–21ACrossRefPubMed
Zurück zum Zitat Pasupathia P, Saravanan G, Raoc Y, Farookc J, Bakthavathsalamc G (2009) Effective analysis of atorvastatin versus in simvastatin patients with hyperlipidemia. J Pharm Sci Res 1:16–21 Pasupathia P, Saravanan G, Raoc Y, Farookc J, Bakthavathsalamc G (2009) Effective analysis of atorvastatin versus in simvastatin patients with hyperlipidemia. J Pharm Sci Res 1:16–21
Zurück zum Zitat Shimoda H, Ninomiya K, Nishida N, Yoshino T, Morikawa T, Matsuda H, Yoshikawa M (2003) Anti-hyperlipidemic sesquiterpenes and new sesquiterpene glycosides from the leaves of artichoke (Cynara scolymus L.): structure requirement and mode of action. Bioorg Med Chem Lett 13:223–228CrossRefPubMed Shimoda H, Ninomiya K, Nishida N, Yoshino T, Morikawa T, Matsuda H, Yoshikawa M (2003) Anti-hyperlipidemic sesquiterpenes and new sesquiterpene glycosides from the leaves of artichoke (Cynara scolymus L.): structure requirement and mode of action. Bioorg Med Chem Lett 13:223–228CrossRefPubMed
Metadaten
Titel
Evaluation of lipid-lowering effect of Cynara scolymus extract-loaded mesoporous silica nanoparticles on ultra-lipid-fed mice
verfasst von
Amir Asadabadi Safat
Hassan Sheibani
Pourya Mohammadi
Navid Hasanabadi
Ehsanollah Sakhaee
Publikationsdatum
08.12.2017
Verlag
Springer London
Erschienen in
Comparative Clinical Pathology / Ausgabe 2/2018
Print ISSN: 1618-5641
Elektronische ISSN: 1618-565X
DOI
https://doi.org/10.1007/s00580-017-2621-1

Weitere Artikel der Ausgabe 2/2018

Comparative Clinical Pathology 2/2018 Zur Ausgabe

Neu im Fachgebiet Pathologie