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13.08.2018 | Ultrasound

Evaluation of liver parenchyma stiffness in patients with liver tumours: optimal strategy for shear wave elastography

verfasst von: Wei Zheng, Zhong-guo Zhou, Chong-hei Wong, Xiao-qing Pei, Shu-lian Zhuang, Qing Li, Min-Shan Chen, An-hua Li, Fu-jun Zhang

Erschienen in: European Radiology | Ausgabe 3/2019

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Abstract

Objectives

To determine the methodology of non-invasive test for evaluation of liver stiffness (LS) with tumours using two-dimensional (2D) shear wave elastography (SWE).

Methods

One hundred and twenty-seven patients with liver tumours underwent 2D-SWE before surgery to measure liver and spleen stiffness (SS). Two-dimensional SWE values were obtained in the liver at 0–1 cm, 1–2 cm and >2 cm from the tumour edge (PLS-1, PLS-2 and RLS, respectively). The influence of tumour-associated factors was evaluated. The area under the receiver operating characteristic curve (AUC) for each value was analysed to diagnose cirrhosis.

Results

PLS-1 was higher than PLS-2, which was even higher than RLS (p < 0.001). The AUCs of PLS-1, PLS-2, RLS and SS for diagnosing cirrhosis were 0.760, 0.833, 0.940 and 0.676, with the specificity of 75.7%, 67.6%, 90.3% and 77.4%, respectively. Tumour sizes, locations or types showed no apparent influence on 2D-SWE values except for RLS, which was higher in patients with primary hepatic carcinomas (p < 0.05).

Conclusions

LS with tumours is best measured at >2 cm away from the tumour edge. SS measurement could be used as an alternative to LS measurement in the event of no available liver for detection.

Key Points

• Tumour-associated factors impact background liver stiffness assessment.

• Background liver stiffness is best measured at >2 cm from tumour edge.

• Spleen stiffness can be an alternative to assess background liver stiffness.

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Titel: Evaluation of liver parenchyma stiffness in patients with liver tumours: optimal strategy for shear wave elastography
verfasst von: Wei Zheng
Zhong-guo Zhou
Chong-hei Wong
Xiao-qing Pei
Shu-lian Zhuang
Qing Li
Min-Shan Chen
An-hua Li
Fu-jun Zhang
Publikationsdatum: 13.08.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: European Radiology / Ausgabe 3/2019
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-018-5676-8

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Evaluation of liver parenchyma stiffness in patients with liver tumours: optimal strategy for shear wave elastography

Abstract

Objectives

Methods

Results

Conclusions

Key Points

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Abstract

Objectives

Methods

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Conclusions

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