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Erschienen in: Neuroradiology 10/2016

25.07.2016 | Interventional Neuroradiology

Evaluation of occurring complications after flow diverter treatment of elastase-induced aneurysm in rabbits using micro-CT and MRI at 9.4 T

verfasst von: Andreas Simgen, Désirée Ley, Christian Roth, Giorgio Franco Maria Cattaneo, Ruben Mühl-Benninghaus, Andreas Müller, Heiko Körner, Yoo-Jin Kim, Bruno Scheller, Wolfgang Reith, Umut Yilmaz

Erschienen in: Neuroradiology | Ausgabe 10/2016

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Abstract

Introduction

Flow diverters are increasingly being used to treat intracranial aneurysms. This study evaluates occurring complications of flow-diverting devices in the treatment of experimental aneurysms, involving the use of micro-CT and small animal MRI at 9.4 T, in correlation to angiographic and histological findings.

Methods

We previously published two preclinical studies, in which we assessed two different flow diverters in the treatment of elastase-induced aneurysms. Devices have been implanted across the aneurysm neck as well as in the abdominal aorta. From these studies, a total of 65 devices (prototype FD (n = 30) and Derivo embolization device (n = 35)) additionally underwent micro-CT and MRI after angiographic follow-up and before being histologically examined.

Results

The different architectures of both devices were precisely comparable due to high-resolution micro-CT imaging. Micro-CT revealed wire fractures in nine cases (30 %) only with the prototype FD. In three cases (10 %), severe wire fractures correlated with an in-stent stenosis due to intimal hyperplasia. Other complications, like distal stent occlusions and post-stent stenosis, were seen in both groups and verified with both imaging techniques. Osseous metaplasia were correlated to calcifications seen with micro-CT. MRI enabled visualization of the position of the implanted devices relative to the aneurysm and revealed incomplete aneurysm neck coverage with the prototype FD in two cases (6.7 %).

Conclusion

Micro-CT and 9.4-T MRI are valid to discover and understand occurring complications of flow diverters in the preclinical phase and can serve as evaluation tools to minimize complication rates of endovascular devices in the future.
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Metadaten
Titel
Evaluation of occurring complications after flow diverter treatment of elastase-induced aneurysm in rabbits using micro-CT and MRI at 9.4 T
verfasst von
Andreas Simgen
Désirée Ley
Christian Roth
Giorgio Franco Maria Cattaneo
Ruben Mühl-Benninghaus
Andreas Müller
Heiko Körner
Yoo-Jin Kim
Bruno Scheller
Wolfgang Reith
Umut Yilmaz
Publikationsdatum
25.07.2016
Verlag
Springer Berlin Heidelberg
Erschienen in
Neuroradiology / Ausgabe 10/2016
Print ISSN: 0028-3940
Elektronische ISSN: 1432-1920
DOI
https://doi.org/10.1007/s00234-016-1730-x

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