Skip to main content
main-content

07.08.2017 | Basic Science | Ausgabe 10/2017

Graefe's Archive for Clinical and Experimental Ophthalmology 10/2017

Evaluation of optic nerve head blood flow in normal rats and a rodent model of non-arteritic ischemic optic neuropathy using laser speckle flowgraphy

Zeitschrift:
Graefe's Archive for Clinical and Experimental Ophthalmology > Ausgabe 10/2017
Autoren:
Hidaka Takako, Chuman Hideki, Nao-i Nobuhisa

Abstract

Purpose

To evaluate optic nerve head (ONH) blood flow in normal rats and a rodent model of non-arteritic ischemic optic neuropathy (rNAION) in vivo using laser speckle flowgraphy (LSFG).

Methods

Rats were under general anesthesia; to induce NAION, Rose Bengal (RB) was injected into the tail vein. After the administration of RB, the left ONH was photoactivated using an argon green laser. We measured ONH blood flow in the normal rats and the rNAION group (at 1, 3, 7, 14, and 28 days after the induction of NAION) using an LSFG-Micro. We used the mean blur rate (MBR) of the vessel region (MV) and MBR of the tissue region (MT) as indicators of blood flow. We compared the MBR of the right and left eyes in both the normal rats and the rNAION group.

Results

In the normal rats, there were no significant differences in MV or MT between the right and left eyes. In the rNAION group, the MV and MT of the affected eyes were significantly lower than those of the unaffected eyes at all time points. There were significant differences between the left/right MV and MT ratios seen before the induction of NAION and those observed at 1, 3, 7, 14, and 28 days after the induction of NAION. However, there were no significant differences in these parameters among any of post-NAION induction time points.

Conclusion

Our results indicated that the ONH blood flow of the rNAION rats fell in the acute and chronic phases.

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

★ PREMIUM-INHALT
e.Med Interdisziplinär

Für Ihren Erfolg in Klinik und Praxis - Die beste Hilfe in Ihrem Arbeitsalltag als Mediziner

Mit e.Med Interdisziplinär erhalten Sie Zugang zu allen CME-Fortbildungen und Fachzeitschriften auf SpringerMedizin.de.

Alle e.Med Abos bis 30. April 2021 zum halben Preis!

Jetzt e.Med zum Sonderpreis bestellen!

Literatur
Über diesen Artikel

Weitere Artikel der Ausgabe 10/2017

Graefe's Archive for Clinical and Experimental Ophthalmology 10/2017 Zur Ausgabe

Neu im Fachgebiet Augenheilkunde

19.03.2021 | Retinitis pigmentosa | Das diagnostische und therapeutische Prinzip | Ausgabe 5/2021 Open Access

Transkorneale Elektrostimulation bei Retinitis pigmentosa

Prüfplan einer multizentrischen, prospektiven, randomisierten, kontrollierten und doppelblinden Studie im Auftrag des Gemeinsamen Bundesausschusses (G-BA-Erprobungsrichtlinie)

17.03.2021 | Glaukom | Leitthema | Ausgabe 5/2021

Bedeutung von Citicolin bei der Glaukomerkrankung