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Clinical Rheumatology

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17.10.2018 | Original Article

Evaluation of subclinical atherosclerosis by ultrasound radiofrequency data technology in patients with primary Sjögren’s syndrome

verfasst von: Cem Ozisler, Hatice Kaplanoglu

Erschienen in: Clinical Rheumatology | Ausgabe 3/2019

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Abstract

Primary Sjögren’s syndrome (pSS) is a chronic inflammatory autoimmune disease, and inflammation is highly associated with atherosclerosis and increased cardiovascular risk. Carotid intima-media thickness (CIMT) and arterial stiffness measurements are commonly used to detect subclinical atherosclerosis. The aim of this study was to non-invasively demonstrate the presence of subclinical atherosclerosis in patients with pSS through these measurements, using ultrasound (US) radiofrequency (RF) data technology. 30 pSS patients as the study group and 30 age-and sex-matched healthy volunteers as the control group were included in this study. The age of the participants in the entire sample ranged from 18 to 60 years, and no primary cardiovascular risk factors were present, such as diabetes mellitus, hypertension, hyperlipidemia, or obesity. The participants in the study and control groups were evaluated with doppler ultrasonography. Arterial stiffness and CIMT measurements were made from the bilateral common carotid arteries (CCA) using US RF data technology. No statistically significant difference was identified between the patients with pSS and the controls in terms of the right, left, and mean CCA IMT; the right side distensibility coefficient (DC) and compliance coefficient (CC); or the right- and left-side α and β stiffness indices values (p > 0.05). Compared to the control subjects, the pSS patients had higher right and left side pulsed wave velocity (PWV), the mean value of the right and the left sides α stiffness index, β stiffness index, and PWV (p < 0.05). The pSS patients’ left DC, left CC, and the mean value of the right and left sides DC and CC were lower than controls (p < 0,05). It was found that patients with pSS show evidence of subclinical atherosclerosis. To determine this situation in patients with pSS, CIMT and PWV measurements may serve as a guide. Radiofrequency data technology represents a non-invasive approach to the accurate and quantitative measurement of CIMT elevation and decreases in vascular elasticity.

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Rischmueller M, Tieu J, Lester S (2016) Primary Sjögren’s syndrome. Best Pract Res Clin Rheumatol 30:189–220CrossRefPubMed

Stefanski AL, Tomiak C, Pleyer U, Dietrich T, Burmester GR, Dörner T (2017) The diagnosis and treatment of Sjögren’s syndrome. Dtsch Arztebl Int 114:354–361PubMedPubMedCentral

Thorne I, Sutcliffe N (2017) Sjögren's syndrome. Br J Hosp Med (Lond) 78:438–442CrossRef

Wu MY, Li CJ, Hou MF, Chu PY (2017) New insights into the role of inflammation in the pathogenesis of atherosclerosis. Int J Mol Sci 22(18):10CrossRef

Wong BW, Meredith A, Lin D, McManus BM (2012) The biological role of inflammation in atherosclerosis. Can J Cardiol 28:631–641CrossRefPubMed

Jain S, Khera R, Corrales-Medina VF, Townsend RR, Chirinos JA (2014) Inflammation and arterial stiffness in humans. Atherosclerosis 237:381–390CrossRefPubMed

Mozos I, Malainer C, Horbańczuk J, Gug C, Stoian D, Luca CT, Atanasov AG (2017) Inflammatory markers for arterial stiffness in cardiovascular diseases. Front Immunol 8:1058CrossRefPubMedPubMedCentral

Yildiz M (2010) Arterial distensibility in chronic inflammatory rheumatic disorders. Open Cardiovasc Med J 4:83–88PubMedPubMedCentral

Nurmohamed MT, Heslinga M, Kitas GD (2015) Cardiovascular comorbidity in rheumatic diseases. Nat Rev Rheumatol 11:693–704CrossRefPubMed

10.

Nezu T, Hosomi N, Aoki S, Matsumoto M (2016) Carotid intima-media thickness for atherosclerosis. J Atheroscler Thromb 23:18–31CrossRefPubMed

11.

Bauer M, Caviezel S, Teynor A, Erbel R, Mahabadi AA, Schmidt-Trucksäss A (2012) Carotid intima-media thickness as a biomarker of subclinical atherosclerosis. Swiss Med Wkly 142:w13705PubMed

12.

Dan HJ, Wang Y, Sha HJ, Wen SB (2012) Quantitative evaluation of the structure and function of the common carotid artery in hypertriglyceridemic subjects using ultrasound radiofrequency-data technology. Eur J Radiol 81:3289–3293CrossRefPubMed

13.

Güneş Tatar İ, Ergun O, Çeltikçi P, Kurt A, Yavaşoğlu N, Birgi E, Tatar T, Hekimoğlu B (2016) Evaluation of subclinical atherosclerosis in migraine patients by ultrasound radiofrequency data technology: preliminary results. Agri 28:121–126PubMed

14.

Jin Y, Chen Y, Tang Q, Xue M, Li W, Jiang J (2013) Evaluation of carotid artery stiffness in obese children using ultrasound radiofrequency data technology. J Ultrasound Med 32:105–113CrossRefPubMed

15.

Mason JC, Libby P (2015) Cardiovascular disease in patients with chronic inflammation: mechanisms underlying premature cardiovascular events in rheumatologic conditions. Eur Heart J 36:482–49cCrossRefPubMed

16.

Vitali C, Bombardieri S, Jonsson R, Moutsopoulos HM, Alexander EL, Carsons SE et al (2002) Classification criteria for Sjögren’s syndrome: a revised version of the European criteria proposed by the American-European consensus group. Ann Rheum Dis 61:554–558CrossRefPubMedPubMedCentral

17.

Meinders JM, Hoeks AP (2004) Simultaneous assessment of diameter and pressure waveforms in the carotid artery. Ultrasound Med Biol 30:147–154CrossRefPubMed

18.

Vinereanu D, Nicolaides E, Boden L et al (2003) Conduit arterial stiffness is associated with impaired left ventricular subendocardial function. Heart 89:449–450CrossRefPubMedPubMedCentral

19.

Pérez-De-Lis M, Akasbi M, Sisó A, Diez-Cascon P, Brito-Zerón P, Diaz-Lagares C, Ortiz J, Perez-Alvarez R, Ramos-Casals M, Coca A (2010) Cardiovascular risk factors in primary Sjögren's syndrome: a case-control study in 624 patients. Lupus 19:941–948CrossRefPubMed

20.

Luni FK, Malik SA, Khan AR, Riaz H, Singh H, Federman D, Kanjwal Y, Dasa O, Khuder S, Kabour A (2017) Risk of ischemic heart disease in patients with Sjögren’s syndrome. Am J Med Sci 354:395–398CrossRefPubMed

21.

Rúa-Figueroa I, Fernández Castro M, Andreu JL, Sanchez-Piedra C, Martínez-Taboada V, Olivé A et al; Sjogrenser and Relesser Researchers and EAS-SER Group (2017) Comorbidities in patients with primary Sjögren’s syndrome and systemic lupus erythematosus: a comparative registries-based study. Arthritis Care Res (Hoboken). 69:38–45

22.

Juarez M, Toms TE, de Pablo P, Mitchell S, Bowman S, Nightingale P, Price EJ, Griffiths B, Hunter J, Gupta M, Bombardieri M, Sutcliffe N, Pitzalis C, Pease C, Andrews J, Emery P, Regan M, Giles I, Isenberg D, Moots R, Collins KS, Ng WF, Kitas GD, on behalf of the UK Primary Sjögren's Syndrome Registry (2014) UK Primary Sjögren’s Syndrome Registry. Cardiovascular risk factors in women with primary Sjögren’s syndrome: United Kingdom primary Sjögren’s syndrome registry results. Arthritis Care Res (Hoboken). 66:757–764CrossRefPubMedPubMedCentral

23.

Chiang CH, Liu CJ, Chen PJ, Leu HB, Hsu CY, Huang PH, Chen TJ, Lin SJ, Chen JW, Chan WL (2013) Primary Sjögren’s syndrome and the risk of acute myocardial infarction: a Nationwide study. Acta Cardiol Sin 29:124–131PubMedPubMedCentral

24.

Vaudo G, Bocci EB, Shoenfeld Y, Schillaci G, Wu R, Del Papa N, Vitali C, Delle Monache F, Marchesi S, Mannarino E, Gerli R (2005) Precocious intima-media thickening in patients with primary Sjögren’s syndrome. Arthritis Rheum 52:3890–3897CrossRefPubMed

25.

Lodde BM, Sankar V, Kok MR, Leakan RA, Tak PP, Pillemer SR (2006) Serum lipid levels in Sjögren’s syndrome. Rheumatology (Oxford) 45:481–484CrossRef

26.

Gerli R, Vaudo G, Bocci EB, Schillaci G, Alunno A, Luccioli F, Hijazi R, Mannarino E, Shoenfeld Y (2010) Functional impairment of the arterial wall in primary Sjögren’s syndrome: combined action of immunologic and inflammatory factors. Arthritis Care Res (Hoboken) 62:712–718CrossRef

27.

Bartoloni E, Baldini C, Schillaci G, Quartuccio L, Priori R, Carubbi F, Bini V, Alunno A, Bombardieri S, de Vita S, Valesini G, Giacomelli R, Gerli R (2015) Cardiovascular disease risk burden in primary Sjögren’s syndrome: results of a population-based multicentre cohort study. J Intern Med 278:185–192CrossRefPubMed

28.

E T, Manthorpe R, Jacobsson LT (2004) Mortality and causes of death in primary Sjögren’s syndrome: a prospective cohort study. Arthritis Rheum 50:1262–1269CrossRef

29.

Chiang CH, Liu CJ, Chen PJ, Huang CC, Hsu CY, Chan WL, Huang PH, Chen TJ, Lin SJ, Chen JW, Leu HB (2014) Primary Sjögren’s syndrome and risk of ischemic stroke: a nationwide study. Clin Rheumatol 33:931–937CrossRefPubMed

30.

Zöller B, Li X, Sundquist J, Sundquist K (2012) Risk of subsequent coronary heart disease in patients hospitalized for immune-mediated diseases: a nationwide follow-up study from Sweden. PLoS One 7:e33442CrossRefPubMedPubMedCentral

31.

Zöller B, Li X, Sundquist J, Sundquist K (2012) Risk of subsequent ischemic and hemorrhagic stroke in patients hospitalized for immune-mediated diseases: a nationwide follow-up study from Sweden. BMC Neurol 18(12):41CrossRef

32.

Zardi EM, Sambataro G, Basta F, Margiotta DP, Afeltra AM (2014) Subclinical carotid atherosclerosis in elderly patients with primary Sjögren syndrome: a duplex Doppler sonographic study. Int J Immunopathol Pharmacol 27:645–651CrossRefPubMed

33.

Garcia AB, Dardin LP, Minali PA, Czapkowsky A, Ajzen SA, Trevisani VF (2016) Asymptomatic atherosclerosis in primary Sjögren syndrome: correlation between low ankle brachial index and autoantibodies positivity. J Clin Rheumatol 22:295–298CrossRefPubMed

34.

Akyel A, Tavil Y, Yayla C, Tufan A, Kaya A, Tezcan ME, Ozturk MA, Boyaci B (2012) Endothelial dysfunction in primary Sjögren syndrome. West Indian Med J 61:870–872CrossRefPubMed

35.

Zardi EM, Basta F, Afeltra A (2016) Levels of vitamin D, disease activity and subclinical atherosclerosis in post-menopausal women with Sjögren’s syndrome: does a link exist? In: In Vivo, vol 30, pp 721–725

36.

Gravani F, Papadaki I, Antypa E, Nezos A, Masselou K, Ioakeimidis D, Koutsilieris M, Moutsopoulos HM, Mavragani CP (2015) Subclinical atherosclerosis and impaired bone health in patients with primary Sjogren’s syndrome: prevalence, clinical and laboratory associations. Arthritis Res Ther 17:99CrossRefPubMedPubMedCentral

37.

Atzeni F, Sarzi-Puttini P, Signorello MC, Gianturco L, Stella D, Boccassini L, Ricci C, Bodini BD, Batticciotto A, De Gennaro-Colonna V, Drago L, Turiel M (2014) New parameters for identifying subclinical atherosclerosis in patients with primary Sjögren’s syndrome: a pilot study. Clin Exp Rheumatol 32:361–368PubMed

38.

Ciçek OF, Bayram NA, Ayhan H, Erten S, Aslan AN, Sarı C, Ozen MB, Bİlen E, Bastuğ S, Durmaz T, Keleş T, Bozkurt E (2014) Assessment of the relationship between aortic stiffness and left ventricular functions with echocardiography in patients with Sjögren’s syndrome. Int J Rheum Dis 17:658–663CrossRefPubMed

39.

Sabio JM, Sánchez-Berná I, Martinez-Bordonado J, Vargas-Hitos JA, Navarrete-Navarrete N, Expósito Ruíz M, Jiménez-Alonso J (2015) Prevalence of and factors associated with increased arterial stiffness in patients with primary Sjögren’s syndrome. Arthritis Care Res (Hoboken). 67:554–562CrossRefPubMed

40.

Sezis Demirci M, Karabulut G, Gungor O, Celtik A, Ok E, Kabasakal Y (2016) Is there an increased arterial stiffness in patients with primary Sjögren’s syndrome? Intern Med 55:455–459CrossRefPubMed

41.

Rachapalli SM, Kiely PD, Bourke BE (2009) Prevalence of abnormal ankle brachial index in patients with primary Sjogren’s syndrome. Clin Rheumatol 28:587–590CrossRefPubMed

Titel: Evaluation of subclinical atherosclerosis by ultrasound radiofrequency data technology in patients with primary Sjögren’s syndrome
verfasst von: Cem Ozisler
Hatice Kaplanoglu
Publikationsdatum: 17.10.2018
Verlag: Springer London
Erschienen in: Clinical Rheumatology / Ausgabe 3/2019
Print ISSN: 0770-3198
Elektronische ISSN: 1434-9949
DOI: https://doi.org/10.1007/s10067-018-4330-9

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