nach oben

Journal of Natural Medicines

Erschienen in:

03.11.2016 | Original Paper

Evaluation of the chemical quality of Sekkoku (石斛) in current Japanese commercial crude drugs: constituents of Flickingeria xantholeuca (Rchb. f.) A.D. Hawkes

verfasst von: Mei Muto, Haruka Asahina, Tatsufumi Yoshioka, Kazuo Ozaki, Makio Shibano

Erschienen in: Journal of Natural Medicines | Ausgabe 1/2017

Einloggen, um Zugang zu erhalten

Abstract

In our investigation, most Shihu (石斛; Japanese name, Sekkoku) in current Japanese commercial crude drugs were from Flickingeria xantholeuca (Orchidaceae). As the index compounds, three new ent-pimarane-type diterpenes, flickinxthanthosides A–C (1–3), one known analogue (7), and three new ent-kaurane-type diterpenes, flickinxanthosides D (4) and E (5) and flickinxanthol A (6) were isolated from the stem of F. xantholeuca. The structures of the new compounds were elucidated on the basis of spectroscopic analyses and chemical methods. We attempted to detect these index compounds from the MeOH extracts of other Dendrobium or Flickingeria plants using TLC and LC/MS.

Xu J, Han QB, Li SL, Chen XJ, Wang XN, Zhao ZZ, Chen HB (2013) Chemistry, bioactivity and quality control of Dendrobium, a commonly used tonic herb in traditional Chinese medicine. Phytochem Rev 12:341–367CrossRef

Ng TB, Liu J, Wong JH, Ye X, Wing Sze SC, Tong Y, Zhang KY (2012) Review of research on Dendrobium, a prized folk medicine. Appl Microbiol Biotechnol 93:1795–1803CrossRefPubMed

Lam Y, Ng TB, Yao RM, Shi J, Xu K, Wing Sze SC, Zhang KY (2015) Evaluation of chemical constituents and important mechanism of pharmacological biology in Dendrobium plants. Evid Based Complement Altern Med 29:841752

Tezuka Y, Hirano H, Kikuchi T, Xu GJ (1991) Constituents of Ephemerantha lonchophylla: isolation of new phenolic compounds, ephemeranthol-A, ephemeranthol-B, and ephemeranthoquinone, and of a new diterpene glucoside, ephemeranthoside. Chem Pharm Bull 39(3):593–598CrossRef

Ma GX, Wang TS, Yin L, Pan Y (1998) Two pimarane diterpenoids from Ephemerantha lonchophylla and their evaluation as modulators of the multidrug resistance phenotype. J Nat Prod 61:112–115CrossRef

Li H, Zhao JJ, Chen JL, Zhu LP, Wang DM, Jiang L, Yang DP, Zhao ZM (2015) Diterpenoids from aerial parts of Flickingeria fimbriata and their nuclear factor-kappaB inhibitory activities. Phytochemistry 117:400–409CrossRefPubMed

Hsu TC, Chung SW, Kuo CM (2012) Supplements to the Orchid flora of Taiwan. Taiwania 57(3):271–277

Snatzke G (1965) Circular dichroism. VIII. Modification of the octant rule for α, β-unsaturated ketones: theory. Tetrahedron 21:413–419CrossRef

Kan Y, Fujita T, Nagai H, Sakamoto B, Hokama Y (1998) Malyngamides M and N from the Hawaiian red alga Gracilaria coronopifolia. J Nat Prod 61:152–155CrossRefPubMed

10.

Tinto WF, Blyden G, Reynolds WF, McLean S (1991) Diterpene and anthraquinone constituents of Glycydendron amazonicum. J Nat Prod 54(4):1127–1130CrossRef

11.

Liu G, Müller R, Rüedi P (2003) Chemical transformations of Phyllocladane (=13β-kaurane) diterpenoids. Helv Chem Acta 86:420–438CrossRef

Titel: Evaluation of the chemical quality of Sekkoku (石斛) in current Japanese commercial crude drugs: constituents of Flickingeria xantholeuca (Rchb. f.) A.D. Hawkes
verfasst von: Mei Muto
Haruka Asahina
Tatsufumi Yoshioka
Kazuo Ozaki
Makio Shibano
Publikationsdatum: 03.11.2016
Verlag: Springer Japan
Erschienen in: Journal of Natural Medicines / Ausgabe 1/2017
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-016-1054-5

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 1/2017

Constituents from Vitex negundo var. heterophylla and their inhibition of nitric oxide production

Ginsenosides, ingredients of the root of Panax ginseng, are not substrates but inhibitors of sodium-glucose transporter 1

Structure and hemolytic activity relationships of triterpenoid saponins and sapogenins

Three new ent-kaurane diterpenes from the herbs of Wedelia prostrata

Chodatiionosides A and B: two new megastigmane glycosides from Chorisia chodatii leaves

Rapid identification of drug-type strains in Cannabis sativa using loop-mediated isothermal amplification assay