Evaluation of the Effectiveness of Injectable Platelet-Rich Fibrın (i-PRF) Addition to Different Particle Sizes of Bovine Bone Grafts in Rabbit Calvaria Defects
- 15.01.2025
- ORIGINAL ARTICLE
Erschienen in:
- Verfasst von
- Oya Törün
- Hüseyin Akçay
- Fatma Ela Şimşek
- Ayşe Yenigün
- Erschienen in
- Journal of Maxillofacial and Oral Surgery | Ausgabe 4/2025
Abstract
Background
Bone grafts are indispensable in augmentation procedures, and their properties influence the new bone formation. It has proved that the injectable platelet-rich fibrin has many positive effects on bone healing.
Aim
It was aimed to compare the effectiveness of the injectable platelet-rich fibrin (i-PRF) addition to bovine bone graft with different particle sizes on bone formation and vascularization in this study.
Materials and Methods
In 18 New Zealand rabbits, critical sized defects were created in the calvarium. Bovine bone grafts of two different particle sizes, small particles (SP) (0.25–1.0 mm) and large particles (LP) (1.0–2.0 mm) were applied with injectable platelet-rich fibrin (i-PRF) and without i-PRF. Animals were killed at 4 and 10 weeks for examining early and late bone healing histomorphometrically and immunohistochemically.
Results
Group SP + i-PRF had the significantly greater amount of new bone formation in both healing periods. The immunoreactivity scores of the vascular endothelial growth factor (VEGF) and osteocalcin (OCN) were found to be significantly higher in Group SP + i-PRF than the other groups. There has been detected significant relationship between i-PRF addition and OCN staining scores.
Conclusion
In this study, which investigated the effectiveness of i-PRF in different particle sizes, it was concluded that i-PRF addition to small-particle bone graft increased new bone formation. There was no significant difference between two particle sizes of bone graft without i-PRF addition.
Anzeige
- Titel
- Evaluation of the Effectiveness of Injectable Platelet-Rich Fibrın (i-PRF) Addition to Different Particle Sizes of Bovine Bone Grafts in Rabbit Calvaria Defects
- Verfasst von
-
Oya Törün
Hüseyin Akçay
Fatma Ela Şimşek
Ayşe Yenigün
- Publikationsdatum
- 15.01.2025
- Verlag
- Springer India
- Erschienen in
-
Journal of Maxillofacial and Oral Surgery / Ausgabe 4/2025
Print ISSN: 0972-8279
Elektronische ISSN: 0974-942X - DOI
- https://doi.org/10.1007/s12663-025-02435-1
Dieser Inhalt ist nur sichtbar, wenn du eingeloggt bist und die entsprechende Berechtigung hast.
