Skip to main content

01.12.2018 | Original contribution | Ausgabe 1/2018 Open Access

Clinical Phytoscience 1/2018

Evaluation of the efficacy of Acalypha wilkesiana leaves in managing cardiovascular disease risk factors in rabbits exposed to salt-loaded diets

Clinical Phytoscience > Ausgabe 1/2018
Kingsley Omage, Marshall A. Azeke, Sylvia O. Omage



This study was conducted to evaluate the therapeutic benefits of oral administration of extracts of Acalypha wilkesiana leaves on some serum parameters that are indicators or risk factors of cardiovascular diseases, in salt loaded rabbits.


Thirty experimental rabbits used for this study were randomized into five groups (A to E) of six rabbits. Rabbits in groups A to D were given salt loaded diets. Groups B and C animals were also treated with aqueous and ethanol extracts of Acalypha wilkesiana leaves respectively while rabbits in group E served as control.


Salt loading resulted in a significantly (P < 0.05) higher serum albumin, cholesterol, LDL-cholesterol and lower serum globulin, HDL-cholesterol, triglycerides, as compared with the control. Treatment with Acalypha wilkesiana leaf extracts (aqueous or ethanol), at a dose of 300 mg/kg body weight, resulted in a significantly (P < 0.05) higher serum triglycerides, HDL-cholesterol, globulin, and lower serum total protein, albumin, LDL-cholesterol, cholesterol, as compared with the control, in the salt loaded rabbits.


Acalypha wilkesiana may be useful in the management of risk factors of cardiovascular diseases.
Über diesen Artikel

Weitere Artikel der Ausgabe 1/2018

Clinical Phytoscience 1/2018 Zur Ausgabe