Background
Methods
Study population
Anthropometric and laboratory measurements
Statistical analyses
Results
Baseline characteristics and metabolic syndrome phenotype
Characteristic | Total population (n = 93) | Metabolic syndrome (n = 65) | No metabolic syndrome (n = 28) |
a
P value
|
---|---|---|---|---|
Omentin-1 (ng/mL) |
149.2 ± 72.7
| 145.7 ± 70.0 | 157.4 ± 79.3 |
0.50
|
Sex (women/men) |
47/46
| 32/33 | 15/13 |
0.70
|
Age (years) |
48 ± 8
| 49 ± 8 | 45 ± 8 |
0.02
|
Current smokers |
24 (25.8%)
| 16 (24.6%) | 8 (12.3%) |
0.69
|
BMI (kg/m2) |
31.3 ± 4.7
| 32.1 ± 4.0 | 29.3 ± 5.6 |
0.02
|
Weight (kg) |
91.6 ± 15.6
| 93.8 ± 13.4 | 86.4 ± 19.2 |
0.01
|
Systolic blood pressure (mm Hg) |
129 ± 14
| 132 ± 14 | 121 ± 12 |
0.001
|
Diastolic blood pressure (mm Hg) |
83 ± 12
| 85 ± 11 | 77 ± 13 |
0.002
|
Waist circumference (cm) |
106.0 ± 11.8
| 108.6 ± 9.5 | 99.9 ± 14.4 |
0.001
|
Fasting plasma glucose (mg/dL) |
93 ± 9
| 95 ± 10 | 89 ± 8 |
0.001
|
Impaired fasting glucose |
28 (30.1%)
| 26 (40.0%) | 2 (7.1%) |
0.002
|
Total cholesterol (mg/dL) |
187 ± 35
| 187 ± 37 | 185 ± 30 |
0.73
|
LDL cholesterol (mg/dL) |
110 ± 29
| 109 ± 30 | 111 ± 25 |
0.80
|
HDL cholesterol (mg/dL) |
44 ± 11
| 41 ± 10 | 50 ± 12 |
<0.001
|
Triglycerides (mg/dL) |
166 ± 83
| 187 ± 80 | 118 ± 71 |
<0.001
|
White blood cell count (x 109/L) |
6.5 ± 2.0
| 6.4 ± 1.8 | 6.7 ± 2.4 |
0.60
|
Correlations between plasma omentin-1 concentrations and metabolic and clinical variables in the entire population
Omentin-1 (ng/mL) | ||
---|---|---|
Variable | Correlation coefficient (r) |
P value
|
Age (years) | 0.143 |
0.17
|
Weight (kg) | -0.067 |
0.52
|
BMI (kg/m2) | -0.081 |
0.44
|
Systolic blood pressure (mm Hg) | 0.198 |
0.06
|
Diastolic blood pressure (mm Hg) | 0.109 |
0.30
|
Waist circumference (cm) | -0.139 |
0.18
|
Fasting plasma glucose (mg/dL) | 0.030 |
0.78
|
Total cholesterol (mg/dL) | 0.068 |
0.52
|
LDL cholesterol (mg/dL) | 0.087 |
0.41
|
HDL cholesterol (mg/dL) | 0.260 |
0.01
|
Triglycerides (mg/dL) | -0.195 |
0.06
|
White blood cell count (x 109/L) | -0.063 |
0.55
|
Omentin-1 (ng/mL) | Omentin-1 (ng/mL) | |||
---|---|---|---|---|
Metabolic syndrome (n = 65) | No metabolic syndrome (n = 28) | |||
Variable | Correlation coefficient (r) |
P value
| Correlation coefficient (r) |
P value
|
Age (years) | 0.154 |
0.22
| 0.191 |
0.33
|
Weight (kg) | -0.063 |
0.62
| -0.033 |
0.87
|
BMI (kg/m2) | 0.015 |
0.90
| -0.207 |
0.29
|
Systolic blood pressure (mm Hg) | 0.226 |
0.07
| 0.270 |
0.17
|
Diastolic blood pressure (mm Hg) | 0.144 |
0.25
| 0.131 |
0.51
|
Waist circumference (cm) | -0.110 |
0.39
| -0.151 |
0.44
|
Fasting plasma glucose (mg/dL) | 0.025 |
0.84
| 0.151 |
0.44
|
Total cholesterol (mg/dL) | 0.150 |
0.23
| -0.168 |
0.39
|
LDL cholesterol (mg/dL) | 0.169 |
0.18
| -0.166 |
0.40
|
HDL cholesterol (mg/dL) | 0.360 |
0.003
| -0.005 |
0.98
|
Triglycerides (mg/dL) | -0.179 |
0.15
| -0.191 |
0.33
|
White blood cell count (x 109/L) | -0.076 |
0.55
| -0.046 |
0.81
|
Relationship between plasma omentin-1 concentrations and sex
All Women (n = 47) | All Men (n = 46) |
a
P value
| Women with metabolic syndrome (n = 32) | Women without metabolic syndrome (n = 15) |
b
P value
| Men with metabolic syndrome (n = 33) | Men without metabolic syndrome (n = 13) |
c
P value
| |
---|---|---|---|---|---|---|---|---|---|
Omentin-1 (ng/mL) | 152.6 ± 70.7 | 145.8 ± 75.2 |
0.55
| 162.0 ± 71.2 | 132.4 ± 67.6 |
0.19
| 129.9 ± 66.0 | 186.3 ± 84.4 |
0.03
|
Age (years) | 47 ± 8 | 48 ± 8 |
0.67
| 48 ± 8 | 45 ± 8 |
0.28
| 50 ± 8 | 44 ± 9 |
0.04
|
Current smokers | 11 (23.4%) | 13 (28.2%) |
0.59
| 7 (21.8%) | 4 (26.7%) |
0.73
| 9 (27.3%) | 4 (30.8%) |
1.00
|
BMI (kg/m2) | 32.4 ± 4.6 | 30.1 ± 4.5 |
0.02
| 33.1 ± 4.2 | 31.0 ± 5.4 |
0.16
| 31.2 ± 3.7 | 27.2 ± 5.3 |
0.005
|
Weight (kg) | 89.0 ± 15.4 | 94.2 ± 15.6 |
0.10
| 92.2 ± 15.4 | 82.4 ± 13.5 |
0.03
| 95.4 ± 11.2 | 91.1 ± 23.9 |
0.36
|
Systolic blood pressure (mm Hg) | 128 ± 16 | 130 ± 13 |
0.48
| 132 ± 16 | 119 ± 13 |
0.01
| 132 ± 13 | 124 ± 11 |
0.040
|
Diastolic blood pressure (mm Hg) | 81 ± 13 | 85 ± 11 |
0.10
| 83 ± 12 | 75 ± 14 |
0.04
| 87 ± 10 | 79 ± 11 |
0.03
|
Waist circumference (cm) | 104.3 ± 11.1 | 107.7 ± 12.4 |
0.16
| 106.8 ± 10 | 98.9 ±11.6 |
0.02
| 110.4 ± 8.7 | 101.0 ± 17.4 |
0.08
|
Fasting plasma glucose (mg/dL) | 93 ± 9 | 93 ± 10 |
0.89
| 95 ± 9 | 89 ± 7 |
0.03
| 95 ± 10 | 88 ± 8 |
0.02
|
Impaired fasting glucose | 13 (27.7%) | 15 (32.6%) |
0.60
| 12 (37.5%) | 1 (6.7%) |
0.04
| 14 (42.4%) | 1 (7.7%) |
0.04
|
Total cholesterol (mg/dL) | 184 ± 34 | 190 ± 36 |
0.43
| 185 ± 39 | 181 ± 22 |
0.71
| 190 ± 36 | 189 ± 39 |
0.94
|
LDL cholesterol (mg/dL) | 107 ± 27 | 113 ± 30 |
0.33
| 108 ± 28 | 104 ± 23 |
0.61
| 110 ± 32 | 119 ± 26 |
0.39
|
HDL cholesterol (mg/dL) | 47 ± 13 | 40 ± 8 |
<0.001
| 44 ± 10 | 55 ± 14 |
0.002
| 38 ± 8 | 44 ± 7 |
0.01
|
Triglycerides (mg/dL) | 146 ± 79 | 186 ± 84 |
0.02
| 163 ± 80 | 109 ± 64 |
0.01
| 209 ± 75 | 128 ± 79 |
<0.001
|
White blood cell count (x 109/L) | 6.8 ± 2.3 | 6.2 ± 1.6 |
0.34
| 6.7 ± 2.3 | 7.0 ± 2.5 |
0.63
| 6.2 ± 1.2 | 6.4 ± 2.3 |
0.89
|