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Erschienen in:

03.08.2023 | Original Article

Evaluation of the therapeutic efficacy of some essential oils in experimentally immunosuppressed mice infected with Cryptosporidium parvum

verfasst von: Noha Madbouly Taha, Rabab Sayed Zalat, Eman Khaled, Basma M. Elmansory

Erschienen in: Journal of Parasitic Diseases | Ausgabe 4/2023

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Abstract

Cryptosporidiosis is a serious intestinal disease affecting mal-nourished children and immunocompromised individuals with severe fatal diarrhea. Our present work was done to evaluate the possible curative effects of different essential oils (Mint, Thyme, Chamomile and Basil) on Cryptosporidium parvum (C. parvum) in vivo compared with nitazoxanide (NTZ). Seventy immunosuppressed white Albino male mice were allocated in 7 groups as follows: group I infected and not treated (Positive control), group II (GII) treated with NTZ, group III (GIII) treated with Mint essential oil, group IV (GIV) treated with Thyme essential oil, group V (GV) treated with Chamomile essential oil, group VI (GVI) treated with Basil essential oil and group VII (GVII) naïve not infected mice (Negative control). Evaluation was done using parasitological, histopatholgical, serological as well as biochemical methods. All study groups revealed significant reduction (P value < 0.01) in the mean number of C. parvum oocysts in stool. Results of GII were the best with 87.7% reduction in the oocysts count followed by GIII (77.9%), GIV (74.7%), GVI (68.2%) and lastly GV (67.2%). Improvement of the histopathological damage in the small intestine was shown in treated groups. All treated mice showed significant upregulation in the interferon gamma (IFN-γ) levels, significant reduction in the malondialdehyde (MDA) levels and increase in superoxide dismutase (SOD) levels (P value < 0.0001). It is concluded that Mint, Thyme, Chamomile and Basil oils showed promising anti-cryptosporidial, anti-inflammatory and antioxidant functions.
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Metadaten
Titel
Evaluation of the therapeutic efficacy of some essential oils in experimentally immunosuppressed mice infected with Cryptosporidium parvum
verfasst von
Noha Madbouly Taha
Rabab Sayed Zalat
Eman Khaled
Basma M. Elmansory
Publikationsdatum
03.08.2023
Verlag
Springer India
Erschienen in
Journal of Parasitic Diseases / Ausgabe 4/2023
Print ISSN: 0971-7196
Elektronische ISSN: 0975-0703
DOI
https://doi.org/10.1007/s12639-023-01621-7

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Beim nicht-muskelinvasiven Blasenkrebs scheint eine hohe Flüssigkeitszufuhr keinen schützenden Effekt in Bezug auf das Risiko eines Rezidivs oder einer Krankheitsprogression zu haben. Eine niederländische Studie legt sogar nahe, dass große Trinkmengen das Fortschreiten der Erkrankung begünstigen könnten.

Urintest auf Prostatakrebs funktioniert mit Erststrahlurin

Ein auf die Expression von 18 Genen gestützter Urintest auf klinisch signifikanten Prostatakrebs könnte offenbar auch in Anwendung auf Erststrahlurin dazu dienen, unnötige Biopsien zu vermeiden.

Vier-Punkte-Regel zum Abbruch der Reanimation

Für die Beendigung von Wiederbelebungsmaßnahmen nach Herzstillstand in Kliniken schlägt ein internationales Team eine Vier-Punkte-Regel vor. Deren Zuverlässigkeit wurde in einer skandinavischen Kohortenstudie validiert.

Hilft eine Metaanalyse, die Kortison-Kontroverse bei Lungenentzündung beizulegen?

Eine aufwendige Re-Analyse von randomisierten kontrollierten klinischen Studien liefert Hinweise darauf, wer – und wer eher nicht – bei einer ambulant erworbenen Pneumonie (CAP) von Glukokortikoiden profitieren könnte. Entscheidend ist demnach der Entzündungsmarker CRP.

EKG Essentials: EKG befunden mit System (Link öffnet in neuem Fenster)

In diesem CME-Kurs können Sie Ihr Wissen zur EKG-Befundung anhand von zwölf Video-Tutorials auffrischen und 10 CME-Punkte sammeln.
Praxisnah, relevant und mit vielen Tipps & Tricks vom Profi.

Update Innere Medizin

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