Introduction
Methods
Results
Variable | Men | Women | All |
---|---|---|---|
Individuals, n (%) | 37,677 (40.5) | 55,454 (59.5) | 93,131 |
Age, years | 52.3 (10.8) | 50.7 (10.5) | 51.4 (10.7) |
Random blood glucosea, mmol/l | 6.0 (2.4) | 6.2 (2.4) | 6.1 (2.4) |
WC, cm | 82.0 (9.7) | 79.1 (9.6) | 80.3 (9.8) |
Hip circumference, cm | 90.6 (6.8) | 91.1 (6.9) | 90.9 (6.9) |
BMI, kg/m2
| 23.4 (3.2) | 23.8 (3.5) | 23.6 (3.4) |
WHR | 0.90 (0.06) | 0.87 (0.07) | 0.88 (0.07) |
PBF, % | 21.9 (6.2) | 32.1 (7.2) | 28.1 (8.4) |
Diabetes, n (%) | 2,678 (7.1) | 4,431 (8.0) | 7,109 (7.6) |
Clinically identified | 1,101 (2.9) | 1,802 (3.3) | 2,903 (3.1) |
Screen-detected | 991 (2.6) | 1,589 (2.9) | 2,580 (2.8) |
Incident | 586 (1.6) | 1,040 (1.9) | 1,626 (1.8) |
CHR | SNP ID | Nearby genes | R/A | Risk allele frequency | CKB (up to 7,109 cases and 86,022 controls) | AGEN-T2D consortium (up to 25,079 cases and 29,611 controls) | Meta-analysisa (CKB + AGEN-T2D) (up to 32,188 cases and 115,633 controls) | Reported populationb
| |||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
CKB | CHB + CHS | CEU | OR (95% CI) |
p value |
n
| OR (95% CI) |
p value | OR (95% CI) |
p value |
p
hetero
c
| |||||
1 | rs10923931 |
NOTCH2
| T/G | 0.032 | 0.041 | 0.081 | 1.16 (1.05, 1.27) | 2.5 × 10−3
| 93,125 | 1.00 (0.86, 1.16) | 9.90 × 10−1
| 1.11 (1.02, 1.20) | 1.07 × 10−2
| 1.05 × 10−1
| EU |
1 | rs340874 |
PROX1
| C/T | 0.391 | 0.394 | 0.525 | 1.05 (1.01, 1.09) | 5.5 × 10−3
| 93,106 | 1.08 (1.03, 1.14) | 2.84 × 10−3
| 1.06 (1.03, 1.09) | 5.06 × 10−5* | 3.44 × 10−1
| EU |
2 | rs780094 |
GCKR
| C/T | 0.488 | 0.459 | 0.591 | 1.08 (1.04, 1.12) | 1.3 × 10−5* | 93,120 | 1.06 (1.01, 1.11) | 2.10 × 10−2
| 1.07 (1.04, 1.10) | 8.73 × 10−7* | 4.96 × 10−1
| EU |
2 | rs7578597 |
THADA
| T/C | 0.993 | 0.993 | 0.417 | 1.27 (1.01, 1.60) | 4.4 × 10−2
| 93,131 | 0.93 (0.62, 1.40) | 7.37 × 10−1
| 1.18 (0.96, 1.44) | 1.12 × 10−1
| 1.97 × 10−1
| EU |
2 | rs243021 |
BCL11A
| A/G | 0.670 | 0.644 | 0.480 | 1.07 (1.03, 1.11) | 3.4 × 10−4* | 93,125 | 1.05 (1.00, 1.10) | 4.02 × 10−2
| 1.06 (1.03, 1.09) | 5.56 × 10−5* | 5.02 × 10−1
| EU |
2 | rs7593730 |
RBMS1
| C/T | 0.836 | 0.808 | 0.818 | 0.98 (0.93, 1.02) | 3.4 × 10−1
| 93,129 | 1.00 (0.94, 1.07) | 9.20 × 10−1
| 0.99 (0.95, 1.02) | 4.75 × 10−1
| 5.33 × 10−1
| EU |
2 | rs3923113 |
GRB14
| A/C | 0.866 | 0.849 | 0.591 | 1.00 (0.95, 1.05) | 9.7 × 10−1
| 93,088 | 1.03 (0.95, 1.12) | 4.80 × 10−1
| 1.01 (0.97, 1.05) | 6.73 × 10−1
| 5.44 × 10−1
| SA |
2 | rs2943641 |
IRS1
| C/T | 0.925 | 0.928 | 0.662 | 1.04 (0.97, 1.11) | 2.5 × 10−1
| 93,104 | 1.12 (1.03, 1.22) | 1.11 × 10−2
| 1.07 (1.02, 1.13) | 1.07 × 10−2
| 1.79 × 10−1
| EU |
3 | rs1801282 |
PPARG
| C/G | 0.946 | 0.959 | 0.904 | 1.07 (0.99, 1.16) | 1.0 × 10−1
| 93,126 | 1.15 (1.01, 1.30) | 3.20 × 10−2
| 1.09 (1.02, 1.16) | 1.22 × 10−2
| 3.54 × 10−1
| EU |
3 | rs6780569 |
UBE2E2
| G/A | 0.798 | 0.779 | 0.909 | 1.11 (1.06, 1.16) | 3.0 × 10−6* | 93,127 | 1.17 (1.12, 1.22) | 1.58 × 10−11
| 1.14 (1.10, 1.18) | 8.32 × 10−16* | 1.26 × 10−1
| EA |
3 | rs831571 |
PSMD6
| C/T | 0.634 | 0.589 | 0.763 | 1.06 (1.02, 1.10) | 1.5 × 10−3
| 93,094 | 1.09 (1.05, 1.13) | 1.36 × 10−6
| 1.08 (1.05, 1.11) | 1.38 × 10−8* | 2.42 × 10−1
| EA |
3 | rs4607103 |
ADAMTS9
| C/T | 0.638 | 0.608 | 0.783 | 1.00 (0.97, 1.04) | 8.6 × 10−1
| 93,114 | 0.99 (0.95, 1.04) | 6.74 × 10−1
| 1.00 (0.97, 1.03) | 9.83 × 10−1
| 7.51 × 10−1
| EU |
3 | rs11708067 |
ADCY5
| A/G | 0.997 | 0.993 | 0.783 | 1.92 (1.28, 2.88) | 1.5 × 10−3
| 93,127 | 1.18 (0.80, 1.74) | 4.04 × 10−1
| 1.49 (1.13, 1.97) | 5.19 × 10−3
| 8.81 × 10−2
| EU |
3 | rs1470579 |
IGF2BP2
| C/A | 0.257 | 0.250 | 0.308 | 1.11 (1.07, 1.16) | 1.1 × 10−7* | 93,108 | 1.15 (1.11, 1.19) | 2.90 × 10−13
| 1.13 (1.10, 1.16) | 4.21 × 10−19* | 2.17 × 10−1
| EU |
3 | rs16861329 |
ST64GAL1
| C/G | 0.809 | 0.764 | 0.869 | 1.04 (1.00, 1.09) | 7.7 × 10−2
| 93,098 | 0.92 (0.86, 0.99) | 1.80 × 10−2
| 1.01 (0.97, 1.04) | 7.69 × 10−1
| 4.50 × 10−3
| SA |
4 | rs6815464 |
MAEA
| C/G | 0.578 | 0.555 | 0.985 | 1.08 (1.04, 1.12) | 3.4 × 10−5* | 93,082 | 1.13 (1.10, 1.16) | 1.57 × 10−20
| 1.11 (1.09, 1.13) | 3.60 × 10−22* | 3.64 × 10−2
| EA |
4 | rs10010131 |
WFS1
| G/A | 0.938 | 0.925 | 0.646 | 1.04 (0.94, 1.15) | 4.7 × 10−1
| 45,198 | 1.00 (0.91, 1.10) | 9.92 × 10−1
| 1.02 (0.95, 1.09) | 6.18 × 10−1
| 6.00 × 10−1
| EU |
5 | rs4457053 |
ZBED3
| G/A | 0.052 | 0.055 | 0.298 | 1.10 (1.02, 1.18) | 1.6 × 10−2
| 93,124 | 1.00 (0.85, 1.18) | 9.77 × 10−1
| 1.08 (1.01, 1.16) | 2.90 × 10−2
| 3.22 × 10−1
| EU |
6 | rs7754840 |
CDKAL1
| C/G | 0.409 | 0.394 | 0.318 | 1.21 (1.17, 1.26) | 3.6 × 10−27* | 93,130 | 1.18 (1.14, 1.22) | 2.94 × 10−20
| 1.20 (1.17, 1.23) | 1.58 × 10−45* | 2.65 × 10−1
| EU |
6 | rs9470794 |
ZFAND3
| C/T | 0.316 | 0.339 | 0.116 | 1.02 (0.98, 1.05) | 4.1 × 10−1
| 93,111 | 1.12 (1.08, 1.16) | 2.06 × 10−10
| 1.07 (1.04, 1.10) | 4.64 × 10−7* | 2.39 × 10−4
| EA |
7 | rs2191349 |
DGKB
| T/G | 0.654 | 0.654 | 0.535 | 1.05 (1.00, 1.09) | 3.5 × 10−2
| 74,375 | 1.12 (1.08, 1.17) | 3.88 × 10−9
| 1.09 (1.06, 1.12) | 8.69 × 10−9* | 1.51 × 10−2
| EU |
7 | rs864745 |
JAZF1
| T/C | 0.766 | 0.786 | 0.505 | 1.04 (1.00, 1.09) | 3.8 × 10−2
| 93,120 | 1.06 (1.00, 1.12) | 3.50 × 10−2
| 1.05 (1.01, 1.09) | 4.65 × 10−3
| 7.21 × 10−1
| EU |
7 | rs4607517 |
GCK
| A/G | 0.211 | 0.195 | 0.207 | 1.01 (0.97, 1.06) | 5.5 × 10−1
| 93,113 | 1.03 (0.97, 1.09) | 3.97 × 10−1
| 1.02 (0.98, 1.05) | 3.02 × 10−1
| 6.84 × 10−1
| EU |
7 | rs6467136 |
GCC1-PAX4
| G/A | 0.784 | 0.776 | 0.520 | 1.04 (1.00, 1.09) | 6.5 × 10−2
| 93,018 | 1.11 (1.07, 1.14) | 4.96 × 10−11
| 1.08 (1.05, 1.11) | 1.58 × 10−9* | 2.92 × 10−2
| EA |
7 | rs972283 |
KLF14
| G/A | 0.710 | 0.697 | 0.540 | 1.04 (1.00, 1.08) | 4.2 × 10−2
| 93,126 | 0.99 (0.93, 1.06) | 8.52 × 10−1
| 1.03 (0.99, 1.06) | 1.00 × 10−1
| 2.22 × 10−1
| EU |
8 | rs896854 |
TP53INP1
| T/C | 0.308 | 0.303 | 0.429 | 1.04 (1.00, 1.08) | 4.4 × 10−2
| 93,127 | 1.07 (1.02, 1.12) | 9.05 × 10−3
| 1.05 (1.02, 1.08) | 9.15 × 10−4* | 3.59 × 10−1
| EU |
8 | rs13266634 |
SLC30A8
| C/T | 0.538 | 0.529 | 0.758 | 1.10 (1.06, 1.13) | 3.4 × 10−8* | 92,535 | 1.10 (1.07, 1.14) | 4.04 × 10−8
| 1.10 (1.07, 1.13) | 7.89 × 10−15* | 7.78 × 10−1
| EU |
9 | rs7041847 |
GLIS3
| A/G | 0.463 | 0.459 | 0.556 | 1.07 (1.03, 1.10) | 2.9 × 10−4* | 92,708 | 1.10 (1.07, 1.13) | 1.99 × 10−14
| 1.09 (1.06, 1.11) | 2.86 × 10−14* | 1.76 × 10−1
| EA |
9 | rs17584499 |
PTPRD
| T/C | 0.101 | 0.091 | 0.202 | 1.00 (0.95, 1.06) | 9.3 × 10−1
| 93,019 | 1.09 (1.00, 1.19) | 4.00 × 10−2
| 1.03 (0.98, 1.08) | 2.48 × 10−1
| 1.13 × 10−1
| EA |
9 | rs10811661 |
CDKN2A/B
| T/C | 0.543 | 0.575 | 0.803 | 1.22 (1.18, 1.26) | 7.1 × 10−28* | 93,062 | 1.12 (1.07, 1.16) | 1.49 × 10−7
| 1.17 (1.14, 1.21) | 1.23 × 10−31* | 1.29 × 10−3
| EU |
9 | rs13292136 |
TLE4/CHCHD9
| C/T | 0.909 | 0.923 | 0.934 | 1.08 (1.01, 1.14) | 2.2 × 10−2
| 93,118 | 0.99 (0.92, 1.07) | 8.84 × 10−1
| 1.04 (0.99, 1.09) | 1.01 × 10−1
| 1.06 × 10−1
| EU |
10 | rs10906115 |
CDC123
| A/G | 0.626 | 0.654 | 0.641 | 1.08 (1.05, 1.12) | 1.1 × 10−5* | 93,076 | 1.08 (1.05, 1.13) | 1.65 × 10−5
| 1.08 (1.06, 1.11) | 7.11 × 10−10* | 9.97 × 10−1
| EA |
10 | rs1802295 |
VPS26A
| T/C | 0.109 | 0.096 | 0.338 | 1.03 (0.97, 1.08) | 3.8 × 10−1
| 93,048 | 1.01 (0.94, 1.09) | 8.00 × 10−1
| 1.02 (0.98, 1.07) | 3.73 × 10−1
| 7.89 × 10−1
| SA |
10 | rs1111875 |
HHEX/IDE
| C/T | 0.279 | 0.279 | 0.581 | 1.11 (1.07, 1.15) | 6.2 × 10−8* | 93,093 | 1.08 (1.04, 1.13) | 8.67 × 10−5
| 1.10 (1.07, 1.13) | 3.47 × 10−11* | 3.81 × 10−1
| EU |
10 | rs7901695 |
TCF7L2
| C/T | 0.031 | 0.026 | 0.328 | 1.37 (1.25, 1.50) | 6.5 × 10−12* | 92,365 | 1.18 (1.03, 1.35) | 1.60 × 10−2, d
| 1.31 (1.21, 1.41) | 1.91 × 10−12* | 6.93 × 10−2
| EU |
10 | rs10886471 |
GRK5
| C/T | 0.794 | 0.774 | 0.455 | 1.00 (0.96, 1.05) | 9.0 × 10−1
| 84,095 | 1.06 (0.99, 1.13) | 1.00 × 10−1
| 1.02 (0.98, 1.06) | 2.97 × 10−1
| 1.93 × 10−1
| EA |
11 | rs4752781 |
DUSP8/INS
| T/A | 0.833 | 0.813 | 0.465 | 0.99 (0.95, 1.04) | 7.3 × 10−1
| 92,932 | 1.04 (0.98, 1.10) | 1.70 × 10−1,e
| 1.01 (0.97, 1.05) | 5.96 × 10−1
| 2.27 × 10−1
| EU |
11 | rs2237892 |
KCNQ1
| C/T | 0.676 | 0.656 | 0.924 | 1.25 (1.20, 1.30) | 4.6 × 10−30* | 92,991 | 1.19 (1.14, 1.24) | 3.62 × 10−18
| 1.22 (1.19, 1.26) | 8.65 × 10−46* | 7.70 × 10−2
| EA |
11 | rs5215 |
KCNJ11
| C/T | 0.386 | 0.387 | 0.384 | 1.07 (1.04, 1.11) | 7.8 × 10−5* | 93,120 | 1.10 (1.06, 1.14) | 2.28 × 10−7
| 1.09 (1.06, 1.11) | 1.22 × 10−10* | 3.69 × 10−1 | EU |
11 | rs1552224 |
ARAP1
| A/C | 0.916 | 0.909 | 0.884 | 1.09 (1.02, 1.16) | 1.1 × 10−2
| 93,130 | 1.16 (1.05, 1.28) | 2.50 × 10−3
| 1.11 (1.05, 1.17) | 1.85 × 10−4* | 2.92 × 10−1
| EU |
11 | rs10830963 |
MTNR1B
| G/C | 0.428 | 0.413 | 0.258 | 1.02 (0.99, 1.06) | 2.0 × 10−1
| 93,107 | 1.00 (0.93, 1.08) | 9.50 × 10−1
| 1.02 (0.99, 1.05) | 2.40 × 10−1
| 6.25 × 10−1
| EU |
12 | rs1531343 |
HMGA2
| C/G | 0.098 | 0.118 | 0.106 | 1.05 (0.99, 1.11) | 9.9 × 10−2
| 92,189 | 1.06 (0.99, 1.14) | 1.05 × 10−1
| 1.05 (1.01, 1.10) | 1.94 × 10−2
| 7.83 × 10−1
| EU |
12 | rs7961581 |
TSPAN8/LGR5
| C/T | 0.215 | 0.204 | 0.263 | 1.04 (1.00, 1.08) | 7.1 × 10−2
| 93,114 | 1.01 (0.95, 1.06) | 8.49 × 10−1
| 1.03 (0.99, 1.06) | 1.31 × 10−1
| 3.18 × 10−1
| EU |
13 | rs1359790 |
SPRY2
| G/A | 0.716 | 0.685 | 0.732 | 1.06 (1.02, 1.10) | 2.5 × 10−3
| 93,096 | 1.05 (1.01, 1.10) | 1.02 × 10−2
| 1.06 (1.03, 1.09) | 7.73 × 10−5* | 7.66 × 10−1
| EA |
15 | rs7403531 |
RASGRP1
| T/C | 0.350 | 0.315 | 0.278 | 1.03 (0.99, 1.07) | 9.3 × 10−2
| 84,075 | 1.08 (1.02, 1.13) | 3.80 × 10−3
| 1.05 (1.02, 1.08) | 2.95 × 10−3
| 2.40 × 10−1
| EA |
15 | rs7172432 |
VPS13C
| A/G | 0.618 | 0.627 | 0.591 | 1.07 (1.03, 1.11) | 4.3 × 10−4* | 93,095 | 1.11 (1.07, 1.15) | 2.86 × 10−8
| 1.09 (1.06, 1.11) | 1.47 × 10−10* | 1.62 × 10−1
| EA |
15 | rs7178572 |
HMG20A
| G/A | 0.350 | 0.382 | 0.687 | 1.07 (1.04, 1.11) | 1.3 × 10−4* | 93,127 | 1.09 (1.04, 1.14) | 4.40 × 10−4
| 1.08 (1.05, 1.11) | 1.43 × 10−7* | 6.41 × 10−1
| SA |
15 | rs11634397 |
ZFAND6
| G/A | 0.088 | 0.077 | 0.657 | 1.02 (0.96, 1.09) | 4.5 × 10−1
| 93,115 | 1.00 (0.90, 1.11) | 9.90 × 10−1
| 1.02 (0.97, 1.07) | 5.14 × 10−1
| 6.95 × 10−1
| EU |
15 | rs2028299 |
AP3S2
| C/A | 0.202 | 0.185 | 0.258 | 1.06 (1.02, 1.11) | 6.0 × 10−3
| 93,115 | 1.08 (1.02, 1.14) | 1.30 × 10−2
| 1.07 (1.03, 1.11) | 1.45 × 10−4* | 6.72 × 10−1
| SA |
15 | rs8042680 |
PRC1
| A/C | 0.990 | 0.998 | 0.283 | 0.88 (0.74, 1.05) | 1.5 × 10−1
| 93,128 | 1.64 (1.16, 2.32) | 4.92 × 10−3
| 1.00 (0.85, 1.16) | 9.61 × 10−1
| 1.60 × 10−3
| EU |
16 | rs9939609 |
FTO
| A/T | 0.124 | 0.147 | 0.444 | 1.15 (1.09, 1.21) | 5.4 × 10−8* | 93,123 | 1.13 (1.07, 1.18) | 5.26 × 10−7
| 1.14 (1.10, 1.18) | 1.76 × 10−13 * | 5.16 × 10−1
| EU |
17 | rs4523957 |
SRR
| T/G | 0.707 | 0.702 | 0.641 | 0.98 (0.94, 1.02) | 3.2 × 10−1
| 90,663 | 1.03 (0.97, 1.09) | 2.70 × 10−1,f
| 0.99 (0.96, 1.03) | 7.61 × 10−1
| 1.85 × 10−1
| EA |
17 | rs4430796 |
HNF1B
| G/A | 0.279 | 0.260 | 0.475 | 1.09 (1.05, 1.14) | 3.8 × 10−6* | 93,089 | 1.12 (1.05, 1.19) | 8.30 × 10−4
| 1.10 (1.07, 1.14) | 8.48 × 10−9* | 5.66 × 10−1
| EU |
18 | rs12970134 |
MC4R
| A/G | 0.188 | 0.173 | 0.288 | 1.06 (1.02, 1.11) | 6.8 × 10−3
| 93,052 | 1.07 (1.02, 1.12) | 2.79 × 10−3
| 1.07 (1.03, 1.10) | 5.76 × 10−5* | 7.82 × 10−1
| EU |
20 | rs6017317 |
HNF4A
| G/T | 0.426 | 0.394 | 0.177 | 1.05 (1.01, 1.08) | 9.9 × 10−3
| 93,123 | 1.09 (1.07, 1.12) | 1.12 × 10−11
| 1.08 (1.06, 1.10) | 2.37 × 10−15* | 3.89 × 10−2
| EA |
23 | rs5945326 |
DUSP9
| A/G | 0.605 | 0.607 | 0.785 | 1.11 (1.07, 1.15) | 4.1 × 10−7* | 92,979 | - | - | - | - | - | EU |
Characteristic | Stratum | Cases/controls | GRS-T | GRS-BC | GRS-IR | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|
OR (95% CI) |
p value |
p
interaction
| OR (95% CI) |
p value |
p
interaction
| OR (95% CI) |
p value |
p
interaction
| |||
BMIa
| |||||||||||
Normal weight | 1,978/39,862 | 1.10 (1.09, 1.11) | 2.28 × 10−72
| 1.13 (1.11, 1.15) | 3.52 × 10−63
| 1.06 (1.03, 1.11) | 8.86 × 10−4
| ||||
Overweight | 3,386/35,711 | 1.08 (1.07, 1.09) | 5.45 × 10−78
| 1.10 (1.09, 1.11) | 4.46 × 10−61
| 1.06 (1.03, 1.09) | 7.39 × 10−5
| ||||
Obese | 1,745/10,438 | 1.06 (1.05, 1.07) | 7.07 × 10−22
| 1.45 × 10−5
| 1.08 (1.06, 1.10) | 3.15 × 10−20
| 8.86 × 10−5
| 1.04 (1.00, 1.08) | 6.29 × 10−2
| 0.37 | |
WCb
| |||||||||||
Low | 1,067/30,046 | 1.11 (1.09, 1.12) | 8.74 × 10−51
| 1.15 (1.13, 1.17) | 5.29 × 10−44
| 1.09 (1.03, 1.14) | 1.36 × 10−3
| ||||
Medium | 2,017/29,075 | 1.08 (1.07, 1.09) | 4.26 × 10−52
| 1.10 (1.08, 1.12) | 1.88 × 10−39
| 1.07 (1.03, 1.11) | 3.44 × 10−4
| ||||
High | 4,025/26,890 | 1.07 (1.06, 1.07) | 1.62 × 10−64
| 4.46 × 10−6
| 1.09 (1.08, 1.10) | 7.35 × 10−57
| 7.03 × 10−5
| 1.04 (1.01, 1.07) | 2.52 × 10−3
| 0.11 | |
WHRc
| |||||||||||
Low | 1,016/30,035 | 1.11 (1.10, 1.13) | 1.29 × 10−50
| 1.14 (1.12, 1.17) | 4.26 × 10−41
| 1.11 (1.06, 1.17) | 4.63 × 10−5
| ||||
Medium | 2,370/32,074 | 1.08 (1.07, 1.09) | 2.70 × 10−59
| 1.11 (1.09, 1.12) | 2.00 × 10−52
| 1.04 (1.00, 1.07) | 3.29 × 10−2
| ||||
High | 3,723/23,902 | 1.06 (1.06, 1.07) | 4.16 × 10−55
| 8.66 × 10−7
| 1.08 (1.07, 1.09) | 4.06 × 10−45
| 3.59 × 10−6
| 1.05 (1.02, 1.08) | 8.93 × 10−4
| 0.15 | |
PBFd
| |||||||||||
Low | 1,392/29,852 | 1.10 (1.09, 1.12) | 1.59 × 10−57
| 1.13 (1.11, 1.15) | 3.74 × 10−47
| 1.06 (1.01, 1.11) | 1.02 × 10−2
| ||||
Medium | 2,180/28,727 | 1.08 (1.07, 1.09) | 6.04 × 10−53
| 1.11 (1.09, 1.12) | 2.38 × 10−45
| 1.05 (1.01, 1.09) | 6.55 × 10−3
| ||||
High | 3,533/27,369 | 1.07 (1.06, 1.08) | 8.19 × 10−58
| 1.97 × 10−5
| 1.09 (1.07, 1.10) | 1.68 × 10−47
| 8.74 × 10−5
| 1.07 (1.04, 1.10) | 5.93 × 10−6
| 0.72 | |
Overall | |||||||||||
7,109/86,022 | 1.08 (1.07, 1.08) | 4.63 × 10−155
| 1.10 (1.09, 1.11) | 2.28 × 10−126
| 1.06 (1.04, 1.08) | 7.05 × 10−8
|