Erschienen in:
17.06.2019 | Original articles
Everolimus- vs. novolimus-eluting bioresorbable scaffolds in patients with acute coronary syndrome
verfasst von:
Prof. H. M. Nef, MD, J. Wiebe, MD, G. Schmidt, H. Möllmann, MD, N. F. Boeder, MD, O. Dörr, MD, T. Bauer, MD, F. Blachutzik, MD, C. Liebetrau, MD, A. Elsässer, MD, N. Foin, MSc, PhD, C. W. Hamm, MD
Erschienen in:
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Abstract
Background
Limited data exist on bioresorbable scaffolds (BRS) in patients with acute coronary syndrome (ACS). The aim of the present study was to evaluate novolimus-eluting BRS (DESolve) as interventional treatment for patients with ACS, and to compare its 12-month outcomes with the everolimus-eluting bioresorbable scaffolds (Absorb).
Methods
In this retrospective study, patients with ACS (including unstable angina pectoris, ST-segment elevation myocardial infarction, or non-ST-segment elevation myocardial infarction) treated with either the Absorb or the DESolve BRS were evaluated in a 1:1 matched-pair analysis. Major adverse cardiac events (MACE), including death, myocardial infarction, and target lesion revascularization, were evaluated as a major endpoint. The occurrence of scaffold thrombosis was also assessed.
Results
A total of 102 patients were eligible for this analysis. The rate of MACE at 12 months was comparable between the Absorb and the DESolve group (8.3% vs. 6.8%, p = 0.738). The occurrence of target lesion revascularization (6.2% vs. 4.7%; p = 0.700) and scaffold thrombosis (4.1% vs. 2.1%; p = 0.580) was comparable as well. All instances of scaffold thrombosis occurred within 30 days of the index procedure.
Conclusion
In this study, similar 12-month event rates were observed for both BRS types after implantation for the treatment of ACS.