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Erschienen in: Urolithiasis 3/2009

01.06.2009 | Original Paper

Evidence suggesting a genetic contribution to kidney stone in northeastern Thai population

verfasst von: Suchai Sritippayawan, Sombat Borvornpadungkitti, Atchara Paemanee, Chagkrapan Predanon, Wattanachai Susaengrat, Duangporn Chuawattana, Nunghathai Sawasdee, Sirintra Nakjang, Suttikarn Pongtepaditep, Choochai Nettuwakul, Nanyawan Rungroj, Somkiat Vasuvattakul, Prida Malasit, Pa-thai Yenchitsomanus

Erschienen in: Urolithiasis | Ausgabe 3/2009

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Abstract

Genetic factor may play a role in the pathogenesis of kidney stone that is found in the northeastern (NE) Thai population. Herein, we report initial evidence suggesting genetic contribution to the disease in this population. We examined 1,034 subjects including 135 patients with kidney stone, 551 family members, and 348 villagers by radiography of kidney–ureter–bladder (KUB) and other methods, and also analyzed stones removed by surgical operations. One hundred and sixteen of 551 family members (21.05%) and 23 of the 348 villagers (6.61%) were affected with kidney stone. The relative risk (λR) of the disease among family members was 3.18. Calcium stones (whewellite, dahllite, and weddellite) were observed in about 88% of stones analyzed. Our data indicate familial aggregation of kidney stone in this population supporting that genetic factor should play some role in its pathogenesis. Genetic and genomic studies will be conducted to identify the genes associated with the disease.
Literatur
1.
Zurück zum Zitat Unakul S (1961) Urinary stones in Thailand: a statistical survey. Siriraj Hosp Gaz 13:199–214 Unakul S (1961) Urinary stones in Thailand: a statistical survey. Siriraj Hosp Gaz 13:199–214
2.
Zurück zum Zitat Chutikorn C, Valyasevi A, Halstead SB (1967) Studies of bladder stone disease in Thailand. II. Hospital experience. Urolithiasis at Ubol Provincial Hospital, 1956–1962. Am J Clin Nutr 20:1320–1328PubMed Chutikorn C, Valyasevi A, Halstead SB (1967) Studies of bladder stone disease in Thailand. II. Hospital experience. Urolithiasis at Ubol Provincial Hospital, 1956–1962. Am J Clin Nutr 20:1320–1328PubMed
4.
Zurück zum Zitat Aegukkatajit S, Nagaphant A, Nuhung R, Sinturat R, Nugoonsawat P, Mungmai P (1994) Epidemiological study of urinary stones based on operative theater data at regional hospitals and general hospitals of public health region-5, Thailand. J Med Assoc Thai 77:284–287 Aegukkatajit S, Nagaphant A, Nuhung R, Sinturat R, Nugoonsawat P, Mungmai P (1994) Epidemiological study of urinary stones based on operative theater data at regional hospitals and general hospitals of public health region-5, Thailand. J Med Assoc Thai 77:284–287
5.
Zurück zum Zitat Aegukkatajit S (1999) Reduction of urinary stone in children from north-eastern Thailand. J Med Assoc Thai 82:1230–1233PubMed Aegukkatajit S (1999) Reduction of urinary stone in children from north-eastern Thailand. J Med Assoc Thai 82:1230–1233PubMed
7.
Zurück zum Zitat Sriboonlue P, Prasongwattana V, Tungsanga K, Tosukhowong P, Phantumvanit P, Bejraputra O et al (1991) Blood and urinary aggregator and inhibitor composition in controls and renal-stone patients from northeastern Thailand. Nephron 59:591–596. doi:10.1159/000186649 PubMedCrossRef Sriboonlue P, Prasongwattana V, Tungsanga K, Tosukhowong P, Phantumvanit P, Bejraputra O et al (1991) Blood and urinary aggregator and inhibitor composition in controls and renal-stone patients from northeastern Thailand. Nephron 59:591–596. doi:10.​1159/​000186649 PubMedCrossRef
8.
Zurück zum Zitat Nilwarangkur S, Malasit P, Nimmannit S, Susaengrat W, Ong-Aj-Yooth S, Vasuvattakul S et al (1990) Urinary constituents in an endemic area of stones and renal tubular acidosis in northeastern Thailand. Southeast Asian J Trop Med Public Health 21:437–441PubMed Nilwarangkur S, Malasit P, Nimmannit S, Susaengrat W, Ong-Aj-Yooth S, Vasuvattakul S et al (1990) Urinary constituents in an endemic area of stones and renal tubular acidosis in northeastern Thailand. Southeast Asian J Trop Med Public Health 21:437–441PubMed
9.
Zurück zum Zitat Sriboonlue P, Tungsanga K, Tosukhowong P, Sitprija V (1993) Seasonal changes in serum and erythrocyte potassium among renal stone formers from northeastern Thailand. Southeast Asian J Trop Med Public Health 24:287–292PubMed Sriboonlue P, Tungsanga K, Tosukhowong P, Sitprija V (1993) Seasonal changes in serum and erythrocyte potassium among renal stone formers from northeastern Thailand. Southeast Asian J Trop Med Public Health 24:287–292PubMed
10.
Zurück zum Zitat Sriboonlue P, Prasongwatana V, Suwantrai S, Bovornpadungkitti S, Tungsanga K, Tosukhowong P (1998) Nutritional potassium status of healthy adult males residing in the rural northeast Thailand. J Med Assoc Thai 81:223–232PubMed Sriboonlue P, Prasongwatana V, Suwantrai S, Bovornpadungkitti S, Tungsanga K, Tosukhowong P (1998) Nutritional potassium status of healthy adult males residing in the rural northeast Thailand. J Med Assoc Thai 81:223–232PubMed
11.
Zurück zum Zitat Nimmannit S, Malasit P, Chaovakul V, Susaengrat W, Vasuvattakul S, Nilwarangkur S (1991) Pathogenesis of sudden unexplained nocturnal death (lai tai) and endemic distal renal tubular acidosis. Lancet 338:930–932. doi:10.1016/0140-6736(91)91786-T PubMedCrossRef Nimmannit S, Malasit P, Chaovakul V, Susaengrat W, Vasuvattakul S, Nilwarangkur S (1991) Pathogenesis of sudden unexplained nocturnal death (lai tai) and endemic distal renal tubular acidosis. Lancet 338:930–932. doi:10.​1016/​0140-6736(91)91786-T PubMedCrossRef
12.
Zurück zum Zitat Nimmannit S, Malasit P, Susaengrat W, Ong-Aj-Yooth S, Vasuvattakul S, Pidetcha P et al (1996) Prevalence of endemic distal renal tubular acidosis and renal stone in the northeast of Thailand. Nephron 72:604–610. doi:10.1159/000188947 PubMedCrossRef Nimmannit S, Malasit P, Susaengrat W, Ong-Aj-Yooth S, Vasuvattakul S, Pidetcha P et al (1996) Prevalence of endemic distal renal tubular acidosis and renal stone in the northeast of Thailand. Nephron 72:604–610. doi:10.​1159/​000188947 PubMedCrossRef
14.
Zurück zum Zitat Romphruk AV, Puapairoj C, Romphruk A, Barasrux S, Urwijitaroon Y, Leelayuwat C (1999) Distributions of HLA-DRB1/DQB1 alleles and haplotypes in the Northeastern Thai population: indicative of a distinct Thai population with Chinese admixtures in the Central Thais. Eur J Immunogenet 26:129–133. doi:10.1046/j.1365-2370.1999.00133.x PubMedCrossRef Romphruk AV, Puapairoj C, Romphruk A, Barasrux S, Urwijitaroon Y, Leelayuwat C (1999) Distributions of HLA-DRB1/DQB1 alleles and haplotypes in the Northeastern Thai population: indicative of a distinct Thai population with Chinese admixtures in the Central Thais. Eur J Immunogenet 26:129–133. doi:10.​1046/​j.​1365-2370.​1999.​00133.​x PubMedCrossRef
15.
Zurück zum Zitat Wrong O, Davies HE (1959) The excretion of acid in renal disease. Q J Med 28:259–313PubMed Wrong O, Davies HE (1959) The excretion of acid in renal disease. Q J Med 28:259–313PubMed
Metadaten
Titel
Evidence suggesting a genetic contribution to kidney stone in northeastern Thai population
verfasst von
Suchai Sritippayawan
Sombat Borvornpadungkitti
Atchara Paemanee
Chagkrapan Predanon
Wattanachai Susaengrat
Duangporn Chuawattana
Nunghathai Sawasdee
Sirintra Nakjang
Suttikarn Pongtepaditep
Choochai Nettuwakul
Nanyawan Rungroj
Somkiat Vasuvattakul
Prida Malasit
Pa-thai Yenchitsomanus
Publikationsdatum
01.06.2009
Verlag
Springer-Verlag
Erschienen in
Urolithiasis / Ausgabe 3/2009
Print ISSN: 2194-7228
Elektronische ISSN: 2194-7236
DOI
https://doi.org/10.1007/s00240-009-0189-1

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