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Pediatric Cardiology

Erschienen in:

01.04.2010 | Riley Symposium

Examining the Cardiac NK-2 Genes in Early Heart Development

verfasst von: Heather Bartlett, Gert Jan C. Veenstra, Daniel L. Weeks

Erschienen in: Pediatric Cardiology | Ausgabe 3/2010

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Abstract

The cardiac NK-2 transcription factors are the vertebrate relatives of the Drosophila tinman gene. Without the Drosophila tinman gene, fruit flies fail to form their heart (“dorsal vessel”), and mutations or altered expression of cardiac NK-2 genes may lead to abnormal heart formation in vertebrates. Although the cardiac NK-2 gene NKX2-5 is recognized as an important factor in cases of human congenital heart disease and heart development in vertebrates, the roles of the other cardiac NK-2 genes are less clear. This report reviews what is known about the cardiac NK-2 genes in cardiac development, comparing studies in several different model systems.

Akazawa H, Komuro I (2005) Cardiac transcription factor Csx/Nkx2–5: its role in cardiac development and diseases. Pharmacol Ther 107:252–268CrossRefPubMed

Akkers RC, van Heeringen SJ, Jacobi UG, Janssen-Megens EM, Francoijs KJ, Stunnenberg HG, Veenstra GJ (2009) A hierarchy of H3K4me3 and H3K27me3 acquisition in spatial gene regulation in Xenopus embryos. Dev Cell 17:425–434CrossRefPubMed

Allen BG, Allen-Brady K, Weeks DL (2006) Reduction of XNkx2-10 expression leads to anterior defects and malformation of the embryonic heart. Mech Dev 123:719–729CrossRefPubMed

Alsan BH, Schultheiss TM (2002) Regulation of avian cardiogenesis by Fgf8 signaling. Development 129:1935–1943PubMed

Backs J, Olson EN (2006) Control of cardiac growth by histone acetylation/deacetylation. Circ Res 98:15–24CrossRefPubMed

Benson DW, Silberbach GM, Kavanaugh-McHugh A, Cottrill C, Zhang Y, Riggs S, Smalls O, Johnson MC, Watson MS, Seidman JG, Seidman CE, Plowden J, Kugler JD (1999) Mutations in the cardiac transcription factor NKX2.5 affect diverse cardiac developmental pathways. J Clin Invest 104:1567–1573CrossRefPubMed

Biben C, Harvey RP (1997) Homeodomain factor Nkx-2.5 controls left/right asymmetric expression of bHLH gene eHand during murine heart development. Genes Dev 11:1357–1369CrossRefPubMed

Brown CO III, Chi X, Garcia-Gras E, Shirai M, Feng XH, Schwartz RJ (2004) The cardiac determination factor, Nkx2–5, is activated by mutual cofactors GATA-4 and Smad1/4 via a novel upstream enhancer. J Biol Chem 279:10659–10669CrossRefPubMed

Chen CY, Schwartz RJ (1995) Identification of novel DNA binding targets and regulatory domains of a murine tinman homeodomain factor, nkx-2.5. J Biol Chem 270:15628–15633CrossRefPubMed

10.

Chen JN, Fishman MC (1996) Zebra fish tinman homolog demarcates the heart field and initiates myocardial differentiation. Development 122:3809–3816PubMed

11.

Chen Y, Yuen WH, Fu J, Huang G, Melendez AJ, Ibrahim FB, Lu H, Cao X (2007) The mitochondrial respiratory chain controls intracellular calcium signaling and NFAT activity essential for heart formation in Xenopus laevis. Mol Cell Biol 27:6420–6432CrossRefPubMed

12.

Cleaver OB, Patterson KD, Krieg PA (1996) Overexpression of the tinman-related genes XNkx-2.5 and XNkx-2.3 in Xenopus embryos results in myocardial hyperplasia. Development 122:3549–3556PubMed

13.

Cripps RM, Olson EN (2002) Control of cardiac development by an evolutionarily conserved transcriptional network. Dev Biol 246:14–28CrossRefPubMed

14.

Durocher D, Chen CY, Ardati A, Schwartz RJ, Nemer M (1996) The atrial natriuretic factor promoter is a downstream target for Nkx-2.5 in the myocardium. Mol Cell Biol 16:4648–4655PubMed

15.

Durocher D, Charron F, Warren R, Schwartz RJ, Nemer M (1997) The cardiac transcription factors Nkx2–5 and GATA-4 are mutual cofactors. Embo J 16:5687–5696CrossRefPubMed

16.

Foley A, Mercola M (2004) Heart induction: embryology to cardiomyocyte regeneration. Trends Cardiovasc Med 14:121–125CrossRefPubMed

17.

Fu Y, Yan W, Mohun TJ, Evans SM (1998) Vertebrate tinman homologues XNkx2–3 and XNkx2–5 are required for heart formation in a functionally redundant manner. Development 125:4439–4449PubMed

18.

Grow MW, Krieg PA (1998) Tinman function is essential for vertebrate heart development: elimination of cardiac differentiation by dominant inhibitory mutants of the tinman-related genes, XNkx2–3 and XNkx2–5. Dev Biol 204:187–196CrossRefPubMed

19.

Habets PE, Moorman AF, Clout DE, van Roon MA, Lingbeek M, van Lohuizen M, Campione M, Christoffels VM (2002) Cooperative action of Tbx2 and Nkx2.5 inhibits ANF expression in the atrioventricular canal: implications for cardiac chamber formation. Genes Dev 16:1234–1246CrossRefPubMed

20.

Harvey RP (1996) NK-2 homeobox genes and heart development. Dev Biol 178:203–216CrossRefPubMed

21.

Heathcote K, Braybrook C, Abushaban L, Guy M, Khetyar ME, Patton MA, Carter ND, Scambler PJ, Syrris P (2005) Common arterial trunk associated with a homeodomain mutation of NKX2.6. Hum Mol Genet 14:585–593CrossRefPubMed

22.

Hiroi Y, Kudoh S, Monzen K, Ikeda Y, Yazaki Y, Nagai R, Komuro I (2001) Tbx5 associates with Nkx2–5 and synergistically promotes cardiomyocyte differentiation. Nat Genet 28:276–280CrossRefPubMed

23.

Inga A, Reamon-Buettner SM, Borlak J, Resnick MA (2005) Functional dissection of sequence-specific NKX2–5 DNA binding domain mutations associated with human heart septation defects using a yeast-based system. Hum Mol Genet 14:1965–1975CrossRefPubMed

24.

Kasahara H, Lee B, Schott JJ, Benson DW, Seidman JG, Seidman CE, Izumo S (2000) Loss of function and inhibitory effects of human CSX/NKX2.5 homeoprotein mutations associated with congenital heart disease. J Clin Invest 106:299–308CrossRefPubMed

25.

Kasahara H, Usheva A, Ueyama T, Aoki H, Horikoshi N, Izumo S (2001) Characterization of homo- and heterodimerization of cardiac Csx/Nkx2.5 homeoprotein. J Biol Chem 276:4570–4580CrossRefPubMed

26.

Kim Y, Nirenberg M (1989) Drosophila NK-homeobox genes. Proc Natl Acad Sci U S A 86:7716–7720CrossRefPubMed

27.

Lien CL, McAnally J, Richardson JA, Olson EN (2002) Cardiac-specific activity of an Nkx2–5 enhancer requires an evolutionarily conserved Smad binding site. Dev Biol 244:257–266CrossRefPubMed

28.

Lints TJ, Parsons LM, Hartley L, Lyons I, Harvey RP (1993) Nkx-2.5: a novel murine homeobox gene expressed in early heart progenitor cells and their myogenic descendants. Development 119:969PubMed

29.

Lyons I, Parsons LM, Hartley L, Li R, Andrews JE, Robb L, Harvey RP (1995) Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeobox gene Nkx2–5. Genes Dev 9:1654–1666CrossRefPubMed

30.

Newman CS, Krieg PA (1998) Tinman-related genes expressed during heart development in Xenopus. Dev Genet 22:230–238CrossRefPubMed

31.

Newman CS, Reecy J, Grow MW, Ni K, Boettger T, Kessel M, Schwartz RJ, Krieg PA (2000) Transient cardiac expression of the tinman-family homeobox gene, XNkx2–10. Mech Dev 91:369–373CrossRefPubMed

32.

Pabst O, Zweigerdt R, Arnold HH (1999) Targeted disruption of the homeobox transcription factor Nkx2–3 in mice results in postnatal lethality and abnormal development of small intestine and spleen. Development 126:2215–2225PubMed

33.

Patterson KD, Cleaver O, Gerber WV, Grow MW, Newman CS, Krieg PA (1998) Homeobox genes in cardiovascular development. Curr Top Dev Biol 40:1–44CrossRefPubMed

34.

Peterkin T, Gibson A, Patient R (2003) GATA-6 maintains BMP-4 and Nkx2 expression during cardiomyocyte precursor maturation. Embo J 22:4260–4273CrossRefPubMed

35.

Riazi AM, Takeuchi JK, Hornberger LK, Zaidi SH, Amini F, Coles J, Bruneau BG, Van Arsdell GS (2009) NKX2–5 regulates the expression of beta-catenin and GATA4 in ventricular myocytes. PLoS One 4:e5698CrossRefPubMed

36.

Sepulveda JL, Belaguli N, Nigam V, Chen CY, Nemer M, Schwartz RJ (1998) GATA-4 and Nkx-2.5 coactivate Nkx-2 DNA binding targets: role for regulating early cardiac gene expression. Mol Cell Biol 18:3405–3415PubMed

37.

Sparrow DB, Cai C, Kotecha S, Latinkic B, Cooper B, Towers N, Evans SM, Mohun TJ (2000) Regulation of the tinman homologues in Xenopus embryos. Dev Biol 227:65–79CrossRefPubMed

38.

Tanaka M, Schinke M, Liao HS, Yamasaki N, Izumo S (2001) Nkx2.5 and Nkx2.6, homologs of Drosophila tinman, are required for development of the pharynx. Mol Cell Biol 21:4391–4398CrossRefPubMed

39.

Tu CT, Yang TC, Tsai HJ (2009) Nkx2.7 and Nkx2.5 function redundantly and are required for cardiac morphogenesis of zebra fish embryos. PLoS One 4:e4249CrossRefPubMed

40.

Yamazaki K, Takahashi A, Takazoe M, Kubo M, Onouchi Y, Fujino A, Kamatani N, Nakamura Y, Hata A (2009) Positive association of genetic variants in the upstream region of NKX2–3 with Crohn’s disease in Japanese patients. Gut 58:228–232CrossRefPubMed

41.

Zeitlinger J, Stark A, Kellis M, Hong JW, Nechaev S, Adelman K, Levine M, Young RA (2007) RNA polymerase stalling at developmental control genes in the Drosophila melanogaster embryo. Nat Genet 39:1512–1516CrossRefPubMed

Titel: Examining the Cardiac NK-2 Genes in Early Heart Development
verfasst von: Heather Bartlett
Gert Jan C. Veenstra
Daniel L. Weeks
Publikationsdatum: 01.04.2010
Verlag: Springer-Verlag
Erschienen in: Pediatric Cardiology / Ausgabe 3/2010
Print ISSN: 0172-0643
Elektronische ISSN: 1432-1971
DOI: https://doi.org/10.1007/s00246-009-9605-0

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