Skip to main content
Erschienen in: Obesity Surgery 8/2021

05.06.2021 | Original Contributions

Expected Values of Esophageal Transit and Gastric Emptying Scintigraphy Post-uncomplicated Sleeve Gastrectomy

verfasst von: Yazmin Johari, Helen Yue, Cheryl Laurie, Geoffrey Hebbard, Paul Beech, Kenneth Sk Yap, Wendy Brown, Paul Burton

Erschienen in: Obesity Surgery | Ausgabe 8/2021

Einloggen, um Zugang zu erhalten

Abstract

Purpose

Sleeve gastrectomy (SG) results in significant anatomical and physiological alterations of the esophagus and stomach, including food tolerance. Currently, there is no consensus on the parameters of abnormal esophageal transit and gastric emptying in this population. We describe standardized esophageal transit and gastric emptying protocols, and define expected values following an uncomplicated SG.

Materials and Methods

In 43 asymptomatic post-SG patients with optimal weight loss, a standardized liquid and semi-solid (oatmeal) esophageal transit study, plus a 90-min semi-solid gastric emptying study with dynamic 5-s image acquisition to assess gastroesophageal reflux, was performed. Gastric emptying half-time and retention rate was calculated. Esophageal transit and reflux were graded by visual inspection of images.

Results

Thirty-one female and 12 male patients participated: mean age 49.0±10.7 years, pre-operative BMI 47.6±7.0 kg/m2, excess weight loss 58.8±26.0% at median follow-up of 7.4 months. The standardized semi-solid meal and liquid preparations were well tolerated. Delays in esophageal transit of liquid and semi-solid boluses were infrequent (7.0% and 16.3% respectively). Deglutitive reflux of both semi-solids and liquids was common (48.8% and 32.6%). The median semi-solid gastric emptying half-time was 21.0 min. A large proportion of substrate transited into the small bowel on initial image acquisition (median 39.1%). Reflux events during gastric emptying were common (median 5.0 events, 12.7% of image acquisition time).

Conclusions

Rapid gastric emptying with asymptomatic deglutitive and post-prandial gastroesophageal reflux events are common following SG. We have defined the expected values of standardized esophageal transit and gastric emptying scintigraphy specifically tailored to SG patients.

Graphical abstract

Literatur
1.
Zurück zum Zitat Felsenreich DM, Prager G, Kefurt R, et al. Quality of life 10 years after sleeve gastrectomy: a multicenter study. Obes Facts. 2019;12(2):157–66.CrossRef Felsenreich DM, Prager G, Kefurt R, et al. Quality of life 10 years after sleeve gastrectomy: a multicenter study. Obes Facts. 2019;12(2):157–66.CrossRef
2.
Zurück zum Zitat Mandeville Y, Van Looveren R, Vancoillie PJ, et al. Moderating the enthusiasm of sleeve gastrectomy: up to fifty percent of reflux symptoms after ten years in a consecutive series of one hundred laparoscopic sleeve gastrectomies. Obes Surg. 2017;27(7):1797–803.CrossRef Mandeville Y, Van Looveren R, Vancoillie PJ, et al. Moderating the enthusiasm of sleeve gastrectomy: up to fifty percent of reflux symptoms after ten years in a consecutive series of one hundred laparoscopic sleeve gastrectomies. Obes Surg. 2017;27(7):1797–803.CrossRef
3.
Zurück zum Zitat Genco A, Soricelli E, Casella G, et al. Gastroesophageal reflux disease and Barrett’s esophagus after laparoscopic sleeve gastrectomy: a possible, underestimated long-term complication. Surg Obes Relat Dis. 2017;13(4):568–74.CrossRef Genco A, Soricelli E, Casella G, et al. Gastroesophageal reflux disease and Barrett’s esophagus after laparoscopic sleeve gastrectomy: a possible, underestimated long-term complication. Surg Obes Relat Dis. 2017;13(4):568–74.CrossRef
4.
Zurück zum Zitat Iannelli A, Treacy P, Sebastianelli L, et al. Perioperative complications of sleeve gastrectomy: review of the literature. Journal of Minimal Access Surgery. 2019;15(1):1–7.CrossRef Iannelli A, Treacy P, Sebastianelli L, et al. Perioperative complications of sleeve gastrectomy: review of the literature. Journal of Minimal Access Surgery. 2019;15(1):1–7.CrossRef
5.
Zurück zum Zitat Braghetto I, Korn O. Late esophagogastric anatomic and functional changes after sleeve gastrectomy and its clinical consequences with regards to gastroesophageal reflux disease. Dis Esophagus. 2019;32(6):10348–57.CrossRef Braghetto I, Korn O. Late esophagogastric anatomic and functional changes after sleeve gastrectomy and its clinical consequences with regards to gastroesophageal reflux disease. Dis Esophagus. 2019;32(6):10348–57.CrossRef
6.
Zurück zum Zitat Yehoshua RT, Eidelman LA, Stein M, et al. Laparoscopic sleeve gastrectomy--volume and pressure assessment. Obes Surg. 2008;18(9):1083–8.CrossRef Yehoshua RT, Eidelman LA, Stein M, et al. Laparoscopic sleeve gastrectomy--volume and pressure assessment. Obes Surg. 2008;18(9):1083–8.CrossRef
7.
Zurück zum Zitat Abell TL, Camilleri M, Donohoe K, et al. Consensus recommendations for gastric emptying scintigraphy: a joint report of the American Neurogastroenterology and Motility Society and the Society of Nuclear Medicine. J Nucl Med Technol. 2008;36(1):44–54.CrossRef Abell TL, Camilleri M, Donohoe K, et al. Consensus recommendations for gastric emptying scintigraphy: a joint report of the American Neurogastroenterology and Motility Society and the Society of Nuclear Medicine. J Nucl Med Technol. 2008;36(1):44–54.CrossRef
8.
Zurück zum Zitat Braghetto I, Davanzo C, Korn O, et al. Scintigraphic evaluation of gastric emptying in obese patients submitted to sleeve gastrectomy compared to normal subjects. Obes Surg. 2009;19(11):1515–21.CrossRef Braghetto I, Davanzo C, Korn O, et al. Scintigraphic evaluation of gastric emptying in obese patients submitted to sleeve gastrectomy compared to normal subjects. Obes Surg. 2009;19(11):1515–21.CrossRef
9.
Zurück zum Zitat Singh M, Lee J, Gupta N, et al. Weight loss can lead to resolution of gastroesophageal reflux disease symptoms: a prospective intervention trial. Obesity (Silver Spring). 2012:284–90. Singh M, Lee J, Gupta N, et al. Weight loss can lead to resolution of gastroesophageal reflux disease symptoms: a prospective intervention trial. Obesity (Silver Spring). 2012:284–90.
10.
Zurück zum Zitat Johari Y, Ooi G, Burton P, et al. Long-term matched comparison of adjustable gastric banding versus sleeve gastrectomy: weight loss, quality of life, hospital resource use and patient-reported outcome measures. Obes Surg. 2020;30(1):214–23.CrossRef Johari Y, Ooi G, Burton P, et al. Long-term matched comparison of adjustable gastric banding versus sleeve gastrectomy: weight loss, quality of life, hospital resource use and patient-reported outcome measures. Obes Surg. 2020;30(1):214–23.CrossRef
11.
Zurück zum Zitat Sista F, Abruzzese V, Clementi M, et al. The effect of sleeve gastrectomy on GLP-1 secretion and gastric emptying: a prospective study. Surg Obes Relat Dis. 2017;13(1):7–14.CrossRef Sista F, Abruzzese V, Clementi M, et al. The effect of sleeve gastrectomy on GLP-1 secretion and gastric emptying: a prospective study. Surg Obes Relat Dis. 2017;13(1):7–14.CrossRef
12.
Zurück zum Zitat Melissas J, Daskalakis M, Koukouraki S, et al. Sleeve gastrectomy-a “food limiting” operation. Obes Surg. 2008;18(10):1251–6.CrossRef Melissas J, Daskalakis M, Koukouraki S, et al. Sleeve gastrectomy-a “food limiting” operation. Obes Surg. 2008;18(10):1251–6.CrossRef
13.
Zurück zum Zitat Bernstine H, Tzioni-Yehoshua R, Groshar D, et al. Gastric emptying is not affected by sleeve gastrectomy--scintigraphic evaluation of gastric emptying after sleeve gastrectomy without removal of the gastric antrum. Obes Surg. 2009;19(3):293–8.CrossRef Bernstine H, Tzioni-Yehoshua R, Groshar D, et al. Gastric emptying is not affected by sleeve gastrectomy--scintigraphic evaluation of gastric emptying after sleeve gastrectomy without removal of the gastric antrum. Obes Surg. 2009;19(3):293–8.CrossRef
14.
Zurück zum Zitat Vigneshwaran B, Wahal A, Aggarwal S, et al. Impact of sleeve gastrectomy on type 2 diabetes mellitus, gastric emptying time, glucagon-like peptide 1 (GLP-1), ghrelin and leptin in non-morbidly obese subjects with BMI 30-35.0 kg/m(2): a Prospective Study. Obes Surg. 2016;26(12):2817–23.CrossRef Vigneshwaran B, Wahal A, Aggarwal S, et al. Impact of sleeve gastrectomy on type 2 diabetes mellitus, gastric emptying time, glucagon-like peptide 1 (GLP-1), ghrelin and leptin in non-morbidly obese subjects with BMI 30-35.0 kg/m(2): a Prospective Study. Obes Surg. 2016;26(12):2817–23.CrossRef
15.
Zurück zum Zitat Burgerhart JS, van Rutte PW, Edelbroek MA, et al. Association between postprandial symptoms and gastric emptying after sleeve gastrectomy. Obes Surg. 2015;25(2):209–14.CrossRef Burgerhart JS, van Rutte PW, Edelbroek MA, et al. Association between postprandial symptoms and gastric emptying after sleeve gastrectomy. Obes Surg. 2015;25(2):209–14.CrossRef
16.
Zurück zum Zitat Corcelles R, Boules M, Froylich D, et al. Total weight loss as the outcome measure of choice after Roux-en-Y gastric bypass. Obes Surg. 2016;26(8):1794–8.CrossRef Corcelles R, Boules M, Froylich D, et al. Total weight loss as the outcome measure of choice after Roux-en-Y gastric bypass. Obes Surg. 2016;26(8):1794–8.CrossRef
17.
Zurück zum Zitat Seok JW. How to interpret gastric emptying scintigraphy. J Neurogastroenterol Motil. 2011;17(2):189–91.CrossRef Seok JW. How to interpret gastric emptying scintigraphy. J Neurogastroenterol Motil. 2011;17(2):189–91.CrossRef
18.
Zurück zum Zitat Pelletier-Galarneau M, Sogbein OO, Pham X, et al. Multicenter validation of a shortened gastric-emptying protocol. J Nucl Med. 2015;56(6):873–6.CrossRef Pelletier-Galarneau M, Sogbein OO, Pham X, et al. Multicenter validation of a shortened gastric-emptying protocol. J Nucl Med. 2015;56(6):873–6.CrossRef
19.
Zurück zum Zitat Bonta DV, Lee HY, Ziessman HA. Shortening the 4-hour gastric-emptying protocol. Clin Nucl Med. 2011;36(4):283–5.CrossRef Bonta DV, Lee HY, Ziessman HA. Shortening the 4-hour gastric-emptying protocol. Clin Nucl Med. 2011;36(4):283–5.CrossRef
20.
Zurück zum Zitat Vargas EJ, Bazerbachi F, Calderon G, et al. Changes in time of gastric emptying after surgical and endoscopic bariatrics and weight loss: a systematic review and meta-analysis. Clin Gastroenterol Hepatol. 2020;18(1):57–68 e5.CrossRef Vargas EJ, Bazerbachi F, Calderon G, et al. Changes in time of gastric emptying after surgical and endoscopic bariatrics and weight loss: a systematic review and meta-analysis. Clin Gastroenterol Hepatol. 2020;18(1):57–68 e5.CrossRef
21.
Zurück zum Zitat Johari Y, Lim G, Wickremasinghe A, Yue H, Seah J, Ooi G, et al. Pathophysiological mechanisms of gastro-esophageal reflux following sleeve gastrectomy. Ann Surg. 2020. Johari Y, Lim G, Wickremasinghe A, Yue H, Seah J, Ooi G, et al. Pathophysiological mechanisms of gastro-esophageal reflux following sleeve gastrectomy. Ann Surg. 2020.
22.
Zurück zum Zitat Oor JE, Roks DJ, Ünlü Ç, et al. Laparoscopic sleeve gastrectomy and gastroesophageal reflux disease- a systematic review and meta-analysis. Am J Surg. 2016;211:250–67.CrossRef Oor JE, Roks DJ, Ünlü Ç, et al. Laparoscopic sleeve gastrectomy and gastroesophageal reflux disease- a systematic review and meta-analysis. Am J Surg. 2016;211:250–67.CrossRef
23.
Zurück zum Zitat Burgerhart JS, Schotborgh CA, Schoon EJ. Effect of sleeve gastrectomy on gastroesophageal reflux. Obes Surg. 2014;24:1436–41.CrossRef Burgerhart JS, Schotborgh CA, Schoon EJ. Effect of sleeve gastrectomy on gastroesophageal reflux. Obes Surg. 2014;24:1436–41.CrossRef
24.
Zurück zum Zitat Del Genio G, Tolone S, Limongelli P, et al. Sleeve gastrectomy and development of “de novo” gastroesophageal reflux. Obes Surg. 2014;24:71–7.CrossRef Del Genio G, Tolone S, Limongelli P, et al. Sleeve gastrectomy and development of “de novo” gastroesophageal reflux. Obes Surg. 2014;24:71–7.CrossRef
Metadaten
Titel
Expected Values of Esophageal Transit and Gastric Emptying Scintigraphy Post-uncomplicated Sleeve Gastrectomy
verfasst von
Yazmin Johari
Helen Yue
Cheryl Laurie
Geoffrey Hebbard
Paul Beech
Kenneth Sk Yap
Wendy Brown
Paul Burton
Publikationsdatum
05.06.2021
Verlag
Springer US
Erschienen in
Obesity Surgery / Ausgabe 8/2021
Print ISSN: 0960-8923
Elektronische ISSN: 1708-0428
DOI
https://doi.org/10.1007/s11695-021-05487-7

Weitere Artikel der Ausgabe 8/2021

Obesity Surgery 8/2021 Zur Ausgabe

Update Chirurgie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

S3-Leitlinie „Diagnostik und Therapie des Karpaltunnelsyndroms“

CME: 2 Punkte

Prof. Dr. med. Gregor Antoniadis Das Karpaltunnelsyndrom ist die häufigste Kompressionsneuropathie peripherer Nerven. Obwohl die Anamnese mit dem nächtlichen Einschlafen der Hand (Brachialgia parästhetica nocturna) sehr typisch ist, ist eine klinisch-neurologische Untersuchung und Elektroneurografie in manchen Fällen auch eine Neurosonografie erforderlich. Im Anfangsstadium sind konservative Maßnahmen (Handgelenksschiene, Ergotherapie) empfehlenswert. Bei nicht Ansprechen der konservativen Therapie oder Auftreten von neurologischen Ausfällen ist eine Dekompression des N. medianus am Karpaltunnel indiziert.

Prof. Dr. med. Gregor Antoniadis
Berufsverband der Deutschen Chirurgie e.V.

S2e-Leitlinie „Distale Radiusfraktur“

CME: 2 Punkte

Dr. med. Benjamin Meyknecht, PD Dr. med. Oliver Pieske Das Webinar S2e-Leitlinie „Distale Radiusfraktur“ beschäftigt sich mit Fragen und Antworten zu Diagnostik und Klassifikation sowie Möglichkeiten des Ausschlusses von Zusatzverletzungen. Die Referenten erläutern, welche Frakturen konservativ behandelt werden können und wie. Das Webinar beantwortet die Frage nach aktuellen operativen Therapiekonzepten: Welcher Zugang, welches Osteosynthesematerial? Auf was muss bei der Nachbehandlung der distalen Radiusfraktur geachtet werden?

PD Dr. med. Oliver Pieske
Dr. med. Benjamin Meyknecht
Berufsverband der Deutschen Chirurgie e.V.

S1-Leitlinie „Empfehlungen zur Therapie der akuten Appendizitis bei Erwachsenen“

CME: 2 Punkte

Dr. med. Mihailo Andric
Inhalte des Webinars zur S1-Leitlinie „Empfehlungen zur Therapie der akuten Appendizitis bei Erwachsenen“ sind die Darstellung des Projektes und des Erstellungswegs zur S1-Leitlinie, die Erläuterung der klinischen Relevanz der Klassifikation EAES 2015, die wissenschaftliche Begründung der wichtigsten Empfehlungen und die Darstellung stadiengerechter Therapieoptionen.

Dr. med. Mihailo Andric
Berufsverband der Deutschen Chirurgie e.V.