Skip to main content
Erschienen in: Aesthetic Plastic Surgery 4/2016

10.06.2016 | Original Article

Experience and Management of Intravascular Injection with Facial Fillers: Results of a Multinational Survey of Experienced Injectors

verfasst von: Greg J. Goodman, Stefania Roberts, Peter Callan

Erschienen in: Aesthetic Plastic Surgery | Ausgabe 4/2016

Einloggen, um Zugang zu erhalten

Abstract

Background

Intravascular injection leading to skin necrosis or blindness is the most serious complication of facial injection with fillers. It may be underreported and the outcome of cases are unclear. Early recognitions of the symptoms and signs may facilitate prompt treatment if it does occur avoiding the potential sequelae of intravascular injection.

Objectives

To determine the frequency of intravascular injection among experienced injectors, the outcomes of these intravascular events, and the management strategies.

Methods

An internet-based survey was sent to 127 injectors worldwide who act as trainers for dermal fillers globally.

Results

Of the 52 respondents from 16 countries, 71 % had ≥11 years of injection experience, and 62 % reported one or more intravascular injections. The most frequent initial signs were minor livedo (63 % of cases), pallor (41 %), and symptoms of pain (37 %). Mildness/absence of pain was a feature of 47 % of events. Hyaluronidase (5 to >500 U) was used immediately on diagnosis to treat 86 % of cases. The most commonly affected areas were the nasolabial fold and nose (39 % each). Of all the cases, only 7 % suffered moderate scarring requiring surface treatments. Uneventful healing was the usual outcome, with 86 % being resolved within 14 days.

Conclusion

Intravascular injection with fillers can occur even at the hands of experienced injectors. It may not be always associated with immediate pain or other classical symptoms and signs. Prompt effective management leads to favorable outcomes, and will prevent catastrophic consequences such as skin necrosis. Intravascular injection leading to blindness may not be salvageable and needs further study.

Level of Evidence V

This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.​springer.​com/​00266.
Literatur
1.
Zurück zum Zitat Bailey SH, Cohen JL, Kenkel JM (2011) Etiology, prevention, and treatment of dermal filler complications. Aesthet Surg J 31:110–121CrossRefPubMed Bailey SH, Cohen JL, Kenkel JM (2011) Etiology, prevention, and treatment of dermal filler complications. Aesthet Surg J 31:110–121CrossRefPubMed
2.
Zurück zum Zitat Liew S, Wu WT, Chan HH, Ho WW et al (2015) Consensus on changing trends, attitudes, and concepts of asian beauty. Aesthetic Plast Surg 40:1–9 Liew S, Wu WT, Chan HH, Ho WW et al (2015) Consensus on changing trends, attitudes, and concepts of asian beauty. Aesthetic Plast Surg 40:1–9
3.
Zurück zum Zitat Ahn JY, Lee SH, Park KY, Hong CK et al (2012) Clinical comparison of two hyaluronic acid-derived fillers in the treatment of nasolabial folds: Mesoglow® and IAL System®. Int J Dermatol 51:601–608CrossRefPubMed Ahn JY, Lee SH, Park KY, Hong CK et al (2012) Clinical comparison of two hyaluronic acid-derived fillers in the treatment of nasolabial folds: Mesoglow® and IAL System®. Int J Dermatol 51:601–608CrossRefPubMed
4.
Zurück zum Zitat Arsiwala SZ (2010) Safety and persistence of non-animal stabilized hyaluronic acid fillers for nasolabial folds correction in 30 Indian patients. J Cutan Aesthet Surg 3:156–161CrossRefPubMedPubMedCentral Arsiwala SZ (2010) Safety and persistence of non-animal stabilized hyaluronic acid fillers for nasolabial folds correction in 30 Indian patients. J Cutan Aesthet Surg 3:156–161CrossRefPubMedPubMedCentral
5.
Zurück zum Zitat Ballin AC, Cazzaniga A, Brandt FS (2013) Long-term efficacy, safety and durability of Juvederm® XC. Clin Cosmet Investig Dermatol 6:183–189PubMedPubMedCentral Ballin AC, Cazzaniga A, Brandt FS (2013) Long-term efficacy, safety and durability of Juvederm® XC. Clin Cosmet Investig Dermatol 6:183–189PubMedPubMedCentral
6.
Zurück zum Zitat Callan P, Goodman GJ, Carlisle I, Liew S et al (2013) Efficacy and safety of a hyaluronic acid filler in subjects treated for correction of midface volume deficiency: a 24 month study. Clin Cosmet Investig Dermatol 6:81–89CrossRefPubMedPubMedCentral Callan P, Goodman GJ, Carlisle I, Liew S et al (2013) Efficacy and safety of a hyaluronic acid filler in subjects treated for correction of midface volume deficiency: a 24 month study. Clin Cosmet Investig Dermatol 6:81–89CrossRefPubMedPubMedCentral
7.
Zurück zum Zitat Kuhne U, Imhof M, Kirchmeir M, Howell DJ (2012) Five-year retrospective review of safety, injected volumes, and longevity of the hyaluronic acid Belotero Basic for facial treatments in 317 patients. J Drugs Dermatol 11:1032–1035PubMed Kuhne U, Imhof M, Kirchmeir M, Howell DJ (2012) Five-year retrospective review of safety, injected volumes, and longevity of the hyaluronic acid Belotero Basic for facial treatments in 317 patients. J Drugs Dermatol 11:1032–1035PubMed
8.
Zurück zum Zitat Narins RS, Coleman WP 3rd, Glogau RG (2009) Recommendations and treatment options for nodules and other filler complications. Dermatol Surg 35(Suppl 2):1667–1671CrossRefPubMed Narins RS, Coleman WP 3rd, Glogau RG (2009) Recommendations and treatment options for nodules and other filler complications. Dermatol Surg 35(Suppl 2):1667–1671CrossRefPubMed
9.
Zurück zum Zitat Cohen JL (2008) Understanding, avoiding, and managing dermal filler complications. Dermatol Surg 34(Suppl 1):S92–S99PubMed Cohen JL (2008) Understanding, avoiding, and managing dermal filler complications. Dermatol Surg 34(Suppl 1):S92–S99PubMed
10.
Zurück zum Zitat Cox SE, Adigun CG (2011) Complications of injectable fillers and neurotoxins. Dermatol Ther 24:524–536CrossRefPubMed Cox SE, Adigun CG (2011) Complications of injectable fillers and neurotoxins. Dermatol Ther 24:524–536CrossRefPubMed
11.
Zurück zum Zitat Daines SM, Williams EF (2013) Complications associated with injectable soft-tissue fillers: a 5-year retrospective review. JAMA Facial Plast Surg 15:226–231CrossRefPubMed Daines SM, Williams EF (2013) Complications associated with injectable soft-tissue fillers: a 5-year retrospective review. JAMA Facial Plast Surg 15:226–231CrossRefPubMed
12.
Zurück zum Zitat De Boulle K, Heydenrych I (2015) Patient factors influencing dermal filler complications: prevention, assessment, and treatment. Clin Cosmet Investig Dermatol 8:205–214CrossRefPubMedPubMedCentral De Boulle K, Heydenrych I (2015) Patient factors influencing dermal filler complications: prevention, assessment, and treatment. Clin Cosmet Investig Dermatol 8:205–214CrossRefPubMedPubMedCentral
13.
14.
Zurück zum Zitat Ozturk CN, Li Y, Tung R, Parker L et al (2013) Complications following injection of soft-tissue fillers. Aesthet Surg J 33:862–877CrossRefPubMed Ozturk CN, Li Y, Tung R, Parker L et al (2013) Complications following injection of soft-tissue fillers. Aesthet Surg J 33:862–877CrossRefPubMed
15.
Zurück zum Zitat Cohen JL, Biesman BS, Dayan SH, DeLorenzi C et al (2015) Treatment of hyaluronic acid filler-induced impending necrosis with hyaluronidase: consensus recommendations. Aesthet Surg J 35:844–849CrossRefPubMed Cohen JL, Biesman BS, Dayan SH, DeLorenzi C et al (2015) Treatment of hyaluronic acid filler-induced impending necrosis with hyaluronidase: consensus recommendations. Aesthet Surg J 35:844–849CrossRefPubMed
16.
Zurück zum Zitat DeLorenzi C (2014) Complications of injectable fillers, part 2: vascular complications. Aesthet Surg J 34:584–600CrossRefPubMed DeLorenzi C (2014) Complications of injectable fillers, part 2: vascular complications. Aesthet Surg J 34:584–600CrossRefPubMed
17.
Zurück zum Zitat Kim DY, Eom JS, Kim JY (2015) Temporary blindness after an anterior chamber cosmetic filler injection. Aesthet Plast Surg 39:428–430CrossRef Kim DY, Eom JS, Kim JY (2015) Temporary blindness after an anterior chamber cosmetic filler injection. Aesthet Plast Surg 39:428–430CrossRef
18.
Zurück zum Zitat Lazzeri D, Agostini T, Figus M, Nardi M et al (2012) Blindness following cosmetic injections of the face. Plast Reconstr Surg 129:995–1012CrossRefPubMed Lazzeri D, Agostini T, Figus M, Nardi M et al (2012) Blindness following cosmetic injections of the face. Plast Reconstr Surg 129:995–1012CrossRefPubMed
19.
Zurück zum Zitat Rzany B, DeLorenzi C (2015) Understanding, avoiding, and managing severe filler complications. Plast Reconstr Surg 136:196S–203SCrossRefPubMed Rzany B, DeLorenzi C (2015) Understanding, avoiding, and managing severe filler complications. Plast Reconstr Surg 136:196S–203SCrossRefPubMed
20.
Zurück zum Zitat Beleznay K, Humphrey S, Carruthers JD, Carruthers A (2014) Vascular compromise from soft tissue augmentation: experience with 12 cases and recommendations for optimal outcomes. J Clin Aesthet Dermatol 7:37–43PubMedPubMedCentral Beleznay K, Humphrey S, Carruthers JD, Carruthers A (2014) Vascular compromise from soft tissue augmentation: experience with 12 cases and recommendations for optimal outcomes. J Clin Aesthet Dermatol 7:37–43PubMedPubMedCentral
21.
Zurück zum Zitat Casabona G (2015) Blood aspiration test for cosmetic fillers to prevent accidental intravascular injection in the face. Dermatol Surg 41:841–847CrossRefPubMed Casabona G (2015) Blood aspiration test for cosmetic fillers to prevent accidental intravascular injection in the face. Dermatol Surg 41:841–847CrossRefPubMed
22.
Zurück zum Zitat Dayan SH, Arkins JP, Mathison CC (2011) Management of impending necrosis associated with soft tissue filler injections. J Drugs Dermatol 10:1007–1012PubMed Dayan SH, Arkins JP, Mathison CC (2011) Management of impending necrosis associated with soft tissue filler injections. J Drugs Dermatol 10:1007–1012PubMed
Metadaten
Titel
Experience and Management of Intravascular Injection with Facial Fillers: Results of a Multinational Survey of Experienced Injectors
verfasst von
Greg J. Goodman
Stefania Roberts
Peter Callan
Publikationsdatum
10.06.2016
Verlag
Springer US
Erschienen in
Aesthetic Plastic Surgery / Ausgabe 4/2016
Print ISSN: 0364-216X
Elektronische ISSN: 1432-5241
DOI
https://doi.org/10.1007/s00266-016-0658-1

Weitere Artikel der Ausgabe 4/2016

Aesthetic Plastic Surgery 4/2016 Zur Ausgabe

Update Chirurgie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

S3-Leitlinie „Diagnostik und Therapie des Karpaltunnelsyndroms“

Karpaltunnelsyndrom BDC Leitlinien Webinare
CME: 2 Punkte

Das Karpaltunnelsyndrom ist die häufigste Kompressionsneuropathie peripherer Nerven. Obwohl die Anamnese mit dem nächtlichen Einschlafen der Hand (Brachialgia parästhetica nocturna) sehr typisch ist, ist eine klinisch-neurologische Untersuchung und Elektroneurografie in manchen Fällen auch eine Neurosonografie erforderlich. Im Anfangsstadium sind konservative Maßnahmen (Handgelenksschiene, Ergotherapie) empfehlenswert. Bei nicht Ansprechen der konservativen Therapie oder Auftreten von neurologischen Ausfällen ist eine Dekompression des N. medianus am Karpaltunnel indiziert.

Prof. Dr. med. Gregor Antoniadis
Berufsverband der Deutschen Chirurgie e.V.

S2e-Leitlinie „Distale Radiusfraktur“

Radiusfraktur BDC Leitlinien Webinare
CME: 2 Punkte

Das Webinar beschäftigt sich mit Fragen und Antworten zu Diagnostik und Klassifikation sowie Möglichkeiten des Ausschlusses von Zusatzverletzungen. Die Referenten erläutern, welche Frakturen konservativ behandelt werden können und wie. Das Webinar beantwortet die Frage nach aktuellen operativen Therapiekonzepten: Welcher Zugang, welches Osteosynthesematerial? Auf was muss bei der Nachbehandlung der distalen Radiusfraktur geachtet werden?

PD Dr. med. Oliver Pieske
Dr. med. Benjamin Meyknecht
Berufsverband der Deutschen Chirurgie e.V.

S1-Leitlinie „Empfehlungen zur Therapie der akuten Appendizitis bei Erwachsenen“

Appendizitis BDC Leitlinien Webinare
CME: 2 Punkte

Inhalte des Webinars zur S1-Leitlinie „Empfehlungen zur Therapie der akuten Appendizitis bei Erwachsenen“ sind die Darstellung des Projektes und des Erstellungswegs zur S1-Leitlinie, die Erläuterung der klinischen Relevanz der Klassifikation EAES 2015, die wissenschaftliche Begründung der wichtigsten Empfehlungen und die Darstellung stadiengerechter Therapieoptionen.

Dr. med. Mihailo Andric
Berufsverband der Deutschen Chirurgie e.V.