nach oben

Erschienen in:

12.05.2015 | Original Paper

Explaining the Efficacy of Pre-exposure Prophylaxis (PrEP) for HIV Prevention: A Qualitative Study of Message Framing and Messaging Preferences Among US Men Who have Sex with Men

verfasst von: Kristen Underhill, Kathleen M. Morrow, Christopher Colleran, Sarah K. Calabrese, Don Operario, Peter Salovey, Kenneth H. Mayer

Erschienen in: AIDS and Behavior | Ausgabe 7/2016

Einloggen, um Zugang zu erhalten

Abstract

We investigated message comprehension and message framing preferences for communicating about PrEP efficacy with US MSM. We conducted eight focus groups (n = 38) and n = 56 individual interviews with MSM in Providence, RI. Facilitators probed comprehension, credibility, and acceptability of efficacy messages, including percentages, non-numerical paraphrases, efficacy ranges versus point estimates, and success- versus failure-framed messages. Our findings indicated a range of comprehension and operational understandings of efficacy messages. Participants tended to prefer percentage-based and success-framed messages, although preferences varied for communicating about efficacy using a single percentage versus a range. Participants reported uncertainty about how to interpret numerical estimates, and many questioned whether trial results would predict personal effectiveness. These results suggest that providers and researchers implementing PrEP may face challenges in communicating with users about efficacy. Efforts to educate MSM about PrEP should incorporate percentage-based information, and message framing decisions may influence message credibility and overall PrEP acceptability.

Baeten JM, Donnell D, Ndase P, et al. Antiretroviral prophylaxis for HIV prevention in heterosexual men and women. N Engl J Med. 2012;367(5):399–410.CrossRefPubMedPubMedCentral

Thigpen MC, Kebaabetswe PM, Paxton LA, et al. Antiretroviral preexposure prophylaxis for heterosexual HIV transmission in Botswana. N Engl J Med. 2012;367(5):423–34.CrossRefPubMed

Choopanya K, Martin M, Suntharasamai P, et al. Antiretroviral prophylaxis for HIV infection in injecting drug users in Bangkok, Thailand (the Bangkok Tenofovir Study): a randomised, double-blind, placebo-controlled phase 3 trial. Lancet. 2013;381(9883):2083–90.CrossRefPubMed

Grant RM, Lama JR, Anderson PL, et al. Preexposure chemoprophylaxis for HIV prevention in men who have sex with men. N Engl J Med. 2010;363:2587–99.CrossRefPubMedPubMedCentral

Molina JM, Capitant C, Charreau I, et al. On demand PrEP with oral TDF-FTC in MSM: results of the ANRS Ipergay trial. Conference on Retroviruses and Opportunistic Infections. Seattle, WA, 2015 [abstract 23LB].

McCormack S, Dunn D. Pragmatic open-label randomised trial of preexposure prophylaxis: the PROUD study. Conference on Retroviruses and Opportunistic Infections. Seattle, WA, 2015 [abstract 22LB].

Young I, McDaid L. How acceptable are antiretrovirals for the prevention of sexually transmitted HIV?: a review of research on the acceptability of oral pre-exposure prophylaxis and treatment as prevention. AIDS Behav. 2014;18(2):195–216.CrossRefPubMed

Eisingerich AB, Wheelock A, Gomez GB, Garnett GP, Dybul MR, Piot PK. Attitudes and acceptance of oral and parenteral HIV preexposure prophylaxis among potential user groups: a multinational study. Plos One. 2012;7(1):e28238.CrossRefPubMedPubMedCentral

Mimiaga MJ, Case P, Johnson CV, Safren SA, Mayer KH. Preexposure antiretroviral prophylaxis attitudes in high-risk Boston area men who report having sex with men: limited knowledge and experience but potential for increased utilization after education. J Acquir Immune Defic Syndr. 2009;50(1):77–83.CrossRefPubMedPubMedCentral

10.

Bauermeister JA, Meanley S, Pingel E, Soler JH, Harper GW. PrEP awareness and perceived barriers among single young men who have sex with men. Curr HIV Res. 2013;11(7):520–7.CrossRefPubMedPubMedCentral

11.

Chen YH, Raymond HF, Grasso M, Nguyen B, Robertson T, McFarland W. Prevalence and predictors of conscious risk behavior among San Franciscan men who have sex with men. AIDS Behav. 2013;17(4):1338–43.CrossRefPubMed

12.

Golub SA, Gamarel KE, Rendina HJ, Surace A, Lelutiu-Weinberger CL. From efficacy to effectiveness: facilitators and barriers to PrEP acceptability and motivations for adherence among MSM and transgender women in New York City. AIDS Patient Care STDs. 2013;27(4):248–54.CrossRefPubMedPubMedCentral

13.

Liu AY, Vittinghoff E, Chillag K, et al. Sexual risk behavior among HIV-uninfected men who have sex with men participating in a tenofovir preexposure prophylaxis randomized trial in the United States. J Acquir Immune Defic Syndr. 2013;64(1):87–94.CrossRefPubMedPubMedCentral

14.

Mustanski B, Johnson AK, Garofalo R, Ryan D, Birkett M. Perceived likelihood of using HIV pre-exposure prophylaxis medications among young men who have sex with men. AIDS Behav. 2013;17(6):2173–9.CrossRefPubMedPubMedCentral

15.

Rucinski KB, Mensah NP, Sepkowitz KA, Cutler BH, Sweeney MM, Myers JE. Knowledge and use of pre-exposure prophylaxis among an online sample of young men who have sex with men in New York City. AIDS Behav. 2013;17(6):2180–4.CrossRefPubMed

16.

Mustanski B, Ryan DT, Sanchez T, Sineath C, Macapagal K, Sullivan PS. Effects of messaging about multiple biomedical and behavioral HIV prevention methods on intentions to use among US MSM: results of an experimental messaging study. AIDS Behav. 2014;18(9):1651–60.CrossRefPubMedPubMedCentral

17.

Underhill K, Morrow KM, Operario D, Mayer KH. Could FDA approval of pre-exposure prophylaxis make a difference? A qualitative study of PrEP acceptability and FDA perceptions among men who have sex with men. AIDS Behav. 2014;18(2):241–9.CrossRefPubMedPubMedCentral

18.

Barash EA, Golden M. Awareness and use of HIV pre-exposure prophylaxis among attendees of a Seattle gay pride event and sexually transmitted disease clinic. AIDS Patient Care STDs. 2010;24(11):689–91.CrossRefPubMed

19.

Mansergh G, Koblin BA, Colfax GN, et al. Preefficacy use and sharing of antiretroviral medications to prevent sexually-transmitted HIV infection among US men who have sex with men. J Acquir Immune Defic Syndr. 2010;55(2):e14–6.CrossRefPubMed

20.

Mehta SA, Silvera R, Bernstein K, Holzman RS, Aberg JA, Daskalakis DC. Awareness of post-exposure HIV prophylaxis in high-risk men who have sex with men in New York City. Sex Transm Infect. 2011;87(4):344–8.CrossRefPubMed

21.

Galindo GR, Walker JJ, Hazelton P, et al. Community member perspectives from transgender women and men who have sex with men on pre-exposure prophylaxis as an HIV prevention strategy: implications for implementation. Implement Sci. 2012;7:116.CrossRefPubMedPubMedCentral

22.

Hosek S, Siberry G, Bell M, et al. The acceptability and feasibility of an HIV pre-exposure prophylaxis (PrEP) trial with young men who have sex with men (YMSM). J Acquir Immune Defic Syndr. 2013;62(4):447–56.CrossRefPubMed

23.

Juusola JL, Brandeau ML, Owens DK, Bendavid E. The cost-effectiveness of preexposure prophylaxis for HIV prevention in the United States in men who have sex with men. Ann Intern Med. 2012;156(8):541–50.CrossRefPubMedPubMedCentral

24.

Krakower DS, Mimiaga MJ, Rosenberger JG, et al. Limited awareness and low immediate uptake of pre-exposure prophylaxis among men who have sex with men using an internet social networking site. Plos One. 2012;7(3):e33119.CrossRefPubMedPubMedCentral

25.

Mansergh G, Koblin BA, Sullivan PS. Challenges for HIV pre-exposure prophylaxis among men who have sex with men in the United States. Plos Med. 2012;9(8):e1001286.CrossRefPubMedPubMedCentral

26.

Koblin BA, Mansergh G, Frye V, et al. Condom-use decision making in the context of hypothetical pre-exposure prophylaxis efficacy among substance-using men who have sex with men: project MIX. J Acquir Immune Defic Syndr. 2011;58(3):319–27.CrossRefPubMed

27.

CDC. CDC fact sheet: HIV and AIDS among gay and bisexual men, 2011.

28.

Smith DK, Thigpen MC, Nesheim SR, et al. Interim guidance for clinicians considering the use of preexposure prophylaxis for the prevention of HIV infection in heterosexually active adults. MMWR. 2012;61:586.

29.

Smith DK, Grant RM, Weidle PJ, Lansky A, Mermin J, Fenton KA. Interim guidance: preexposure prophylaxis for the prevention of HIV infection in men who have sex with men. MMWR. 2011;60(3):65–8.

30.

Smith DK, Martin M, Lansky A, Mermin J, Choopanya K. Update to interim guidance for preexposure prophylaxis (PrEP) for the prevention of HIV infection: PrEP for injecting drug users. MMWR. 2013;62(23):463–5.

31.

World Health Organization. Guidance on oral pre-exposure prophylaxis (PrEP) for serodiscordant couples, men and transgender women who have sex with men at high risk of HIV: recommendations for use in the context of demonstration projects. Geneva, Switzerland: World Health Organization; 2012.

32.

Gilead Sciences Inc. Truvada: Risk Evaluation and Mitigation Strategy. http://www.fda.gov/downloads/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/UCM312304.pdf. Accessed 28 April 2015.

33.

Gilead Sciences Inc. TRUVADA for a pre-exposure prophylaxis indication: training guide for healthcare providers. Foster City, CA: Gilead Sciences Inc.; 2013.

34.

CDC. Preexposure Prophylaxis for the Prevention of HIV Infection in the United States 2014: A Clinical Practice Guideline. Atlanta, GA: CDC; 2014.

35.

FDA. Truvada for PrEP Fact Sheet: Ensuring Safe and Proper Use. Silver Spring, MD: FDA; 2012.

36.

Mayer K, Johnson C, Mimiaga M, Safren S, Case P. Influence of potential symptoms and perceived efficacy on the willingness to use HIV pre-exposure prophylaxis (PrEP) among Boston area men who have sex with men (MSM). 5th IAS Conference on HIV Pathogenesis and Treatment. Cape Town, South Africa, 2009 [abstract WEPEC080].

37.

Anderson PL, Glidden DV, Liu A. Emtricitabine-tenofovir concentrations and pre-exposure prophylaxis efficacy in men who have sex with men. Sci Transl Med. 2012;4(151):151ra125.CrossRefPubMedPubMedCentral

38.

Newman PA, Duan N, Rudy ET, Roberts KJ, Swendeman D. Posttrial HIV vaccine adoption: concerns, motivators, and intentions among persons at risk for HIV. J Acquir Immune Defic Syndr. 2004;37(3):1393–403.CrossRefPubMed

39.

Rothman AJ, Salovey P. Shaping perceptions to motivate healthy behavior: the role of message framing Psychol Bull. 1997;121(1):3–19.PubMed

40.

Linville PW, Fischer GW, Fischhoff B. AIDS risk perceptions and decision biases. In: Pryor JB, Reeder GD, editors. The social psychology of HIV infection. Hillsdale: Erlbaum; 1993. p. 5–38.

41.

Edwards A, Elwyn G, Covey J, Matthews E, Pill R. Presenting risk information: a review of the effects of “framing” and other manipulations on patient outcomes. J Health Commun. 2001;6:61–82.CrossRefPubMed

42.

Gallagher KM, Updegraff JA. Health message framing effects on attitudes, intentions, and behavior: a meta-analytic review. Ann Behav Med. 2012;43(1):101–16.CrossRefPubMed

43.

Rucker DD, Petty RE, Brinol P. What’s in a frame anyway?: a meta-cognitive analysis of the impact of one versus two sided message framing on attitude certainty. J Consum Psychol. 2008;18(2):137–49.CrossRef

44.

Golub SA, Gamarel K, Surace A, Lelutiu-Winberger C. Impact of PrEP messaging factors on comprehension, adherence motivation, and risk compensation intentions. 8th International Conference on HIV Treatment and Prevention Adherence. Miami, FL, 2013 [abstract 125].

45.

Golub SA, Gamarel K, Surace A, Lelutiu-Weinberger CL. Critical lessons for pre-exposure prophylaxis (PrEP) messaging and program development. American Public Health Association140th Annual Meeting. San Francisco, CA, 2014 [abstract 267271].

46.

NVivo 9. Doncaster, Australia, 2012.

47.

Thorne S, Kirkham SR, MacDonald-Emes J. Interpretive description: a noncategorical qualitative alternative for developing nursing knowledge. Res Nurs Health. 1997;20(2):169–77.CrossRefPubMed

48.

Thorne S. Interpretive description. Walnut Creek: Left Coast Press, Inc.; 2008.

49.

Thorne S, Kirkham SR, O’Flynn-Magee K. The analytic challenge in interpretive description. Int J Qual Methods. 2004;3(1):1–11.

50.

Neergaard MA, Olesen F, Andersen RS, Sondergaard J. Qualitative description—the poor cousin of health research? BMC Med Res Methodol. 2009;9:52.CrossRefPubMedPubMedCentral

51.

Barbour RS. Checklists for improving rigour in qualitative research: a case of the tail wagging the dog? BMJ. 2001;322(7294):1115–7.CrossRefPubMedPubMedCentral

52.

Bradley EH, Curry LA, Devers KJ. Qualitative data analysis for health services research: developing taxonomy, themes, and theory. Health Serv Res. 2007;42(4):1758–72.CrossRefPubMedPubMedCentral

53.

Golub SA, Kowalczyk W, Weinberger CL, Parsons JT. Preexposure prophylaxis and predicted condom use among high-risk men who have sex with men. J Acquir Immune Defic Syndr. 2010;54(5):548–55.CrossRefPubMedPubMedCentral

54.

Helweg-Larsen M, Shepperd JA. Do Moderators of the optimistic bias affect personal or target risk estimates? A review of the literature. Pers Soc Psychol Rev. 2001;5(1):74–95.CrossRef

55.

Klein CTF, Helweg-Larsen M. Perceived control and the optimistic bias: a meta-analytic review. Psychol Health. 2002;17:437–46.CrossRef

56.

Lipkus IM, Klein WM, Rimer BK. Communicating breast cancer risks to women using different formats. Cancer Epidemiol Biomark Prev. 2001;10(8):895–8.

57.

Moxey A, O’Connell D, McGettigan P, Henry D. Describing treatment effects to patients. J Gen Intern Med. 2003;18(11):948–59.CrossRefPubMedPubMedCentral

58.

Petty RE, Priester JR, Brinol P. Mass media attitude change: implications of the elaboration likelihood model of persuastion. In: Bryant J, Zillman D, editors. Media effects: advances in theory and research. Mahwah: Lawrence Erlbaum Associates; 2002. p. 155–98.

59.

Smith SM, Petty RE. Message framing and persuasion: a message processing analysis. Pers Soc Psychol Bull. 1996;22(3):257–68.CrossRef

60.

Petty RE, Cacioppo JT. The elaboration likelihood model of persuasion. Adv Exp Soc Psychol. 1986;19:123–205.CrossRef

61.

Kuhn KM. Communicating uncertainty: framing effects on responses to vague probabilities. Org Behav Hum Decis Process. 1997;71(1):55–83.CrossRef

Titel: Explaining the Efficacy of Pre-exposure Prophylaxis (PrEP) for HIV Prevention: A Qualitative Study of Message Framing and Messaging Preferences Among US Men Who have Sex with Men
verfasst von: Kristen Underhill
Kathleen M. Morrow
Christopher Colleran
Sarah K. Calabrese
Don Operario
Peter Salovey
Kenneth H. Mayer
Publikationsdatum: 12.05.2015
Verlag: Springer US
Erschienen in: AIDS and Behavior / Ausgabe 7/2016
Print ISSN: 1090-7165
Elektronische ISSN: 1573-3254
DOI: https://doi.org/10.1007/s10461-015-1088-9

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Innere Medizin

24.04.2024 | DGIM 2024 | Kongressbericht | Nachrichten

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Explaining the Efficacy of Pre-exposure Prophylaxis (PrEP) for HIV Prevention: A Qualitative Study of Message Framing and Messaging Preferences Among US Men Who have Sex with Men

Abstract

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Metformin rückt in den Hintergrund

Myokarditis nach Infekt – richtig schwierig wird es bei Profisportlern

Thrombophiliescreening – Wenn, dann richtig und nur bei therapeutischer Konsequenz

Bei Senioren mit Prostatakarzinom auf Anämie achten!

Update Innere Medizin

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 7/2016

Evaluating the Impact of the US National HIV/AIDS Strategy, 2010–2015

Self-reported Recent PrEP Dosing and Drug Detection in an Open Label PrEP Study

Sexual Behavior, Risk Compensation, and HIV Prevention Strategies Among Participants in the San Francisco PrEP Demonstration Project: A Qualitative Analysis of Counseling Notes

Increasing Belief in the Effectiveness of HIV Treatment as Prevention: Results of Repeated, National Surveys of Australian Gay and Bisexual Men, 2013–15

Depression and Oral FTC/TDF Pre-exposure Prophylaxis (PrEP) Among Men and Transgender Women Who Have Sex With Men (MSM/TGW)

Seasons of Risk: Anticipated Behavior on Vacation and Interest in Episodic Antiretroviral Pre-exposure Prophylaxis (PrEP) Among a Large National Sample of U.S. Men Who have Sex with Men (MSM)

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Metformin rückt in den Hintergrund

Myokarditis nach Infekt – richtig schwierig wird es bei Profisportlern

Thrombophiliescreening – Wenn, dann richtig und nur bei therapeutischer Konsequenz

Bei Senioren mit Prostatakarzinom auf Anämie achten!

Update Innere Medizin