Exploratory Assessment of Preoperative GLP-1 Receptor Agonists Before Sleeve Gastrectomy: A Retrospective Matched Analysis
- 10.09.2025
- Research
Erschienen in:
- Verfasst von
- Guillaume Luc
- Arnaud Dedieu
- Guillaume Canard
- Amélie Cesard
- Amandine Brunet
- Camille Furois
- Angèle Leterrier
- Barbara Daridon
- Lea Mendes
- Emilie Brighen
- Lucie Fournet
- Anaelle David
- Ludivine Muzard
- Erschienen in
- Obesity Surgery | Ausgabe 10/2025
Abstract
Background
Preoperative treatment with glucagon-like peptide-1 receptor agonists (GLP-1 RAs) before bariatric surgery has not been studied. Therefore, we investigated the impact of neoadjuvant treatment with GLP-1 RAs on weight loss and postoperative outcomes in patients who underwent sleeve gastrectomy for severe obesity.
Method
A retrospective single-center study was conducted between January 2022 and December 2023. Patients with morbid obesity who were treated preoperatively with a GLP-1 RA (GLP-1 group) were matched with patients who were not preoperatively treated with a GLP-1 RA (No GLP-1 group) using propensity scores calculated according to age and body mass index (BMI). Between-group differences in demographics, comorbidities, surgical parameters, complications, weight loss, and comorbidity outcomes were analyzed.
Results
Fourteen patients were included in the GLP-1 group and matched with 28 controls (1:2 ratio). Preoperative weight loss was significantly greater in the GLP-1 group (7.8 ± 6.8 kg) than in the control group (0.2 ± 4.5 kg), with a mean difference of + 7.54 kg (95% CI: [3.47;11.6], p = 0.001, Cohen’s d = 1.41). Mixed-effects ANOVA revealed a significant effect of time, with progressive BMI reduction in both groups (p = 0.019), no main effect of group (p = 0.080), and no group–time interaction (p = 0.972), indicating similar BMI trajectories throughout the perioperative period and no between-group difference at 12 months. Postoperative vomiting occurred in 21.4% of patients in the GLP-1 group versus 0% in the No GLP-1 group (p = 0.031). No significant differences in surgical parameters or the comorbidity resolution rate at one year were found.
Conclusion
Neoadjuvant GLP-1 RA treatment increased preoperative weight loss before sleeve gastrectomy, but the benefit was not sustained postoperatively. Preoperative GLP-1 RA use could be considered to optimize surgical preparation, but further data regarding postoperative outcomes and long-term weight benefits are needed.
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- Titel
- Exploratory Assessment of Preoperative GLP-1 Receptor Agonists Before Sleeve Gastrectomy: A Retrospective Matched Analysis
- Verfasst von
-
Guillaume Luc
Arnaud Dedieu
Guillaume Canard
Amélie Cesard
Amandine Brunet
Camille Furois
Angèle Leterrier
Barbara Daridon
Lea Mendes
Emilie Brighen
Lucie Fournet
Anaelle David
Ludivine Muzard
- Publikationsdatum
- 10.09.2025
- Verlag
- Springer US
- Erschienen in
-
Obesity Surgery / Ausgabe 10/2025
Print ISSN: 0960-8923
Elektronische ISSN: 1708-0428 - DOI
- https://doi.org/10.1007/s11695-025-08258-w
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