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Journal of Gastrointestinal Cancer

Erschienen in:

17.02.2018 | Original Research

Expression Level of miR-34a in Tumor Tissue from Patients with Esophageal Squamous Cell Carcinoma

verfasst von: Milad Asadi, Dariush Shanehbandi, Hanieh Mohammadpour, Shahriyar Hashemzadeh, Bita Sepehri

Erschienen in: Journal of Gastrointestinal Cancer | Ausgabe 2/2019

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Abstract

Background

miR-34a has been shown to be involved in P53 regulation. In this study, we aimed to evaluate the expression level of miR-34a in esophageal cancer and compare it with that of the normal marginal tissues.

Methods

Tumor and marginal tissues were obtained from 50 patients with esophageal cancer. After RNA extraction, expression level of miR-34a was determined using SYBR green master mix and real-time quantitative PCR.

Results

It was observed that there was a downregulation of miR-34a in tumoral tissue of esophageal patients in comparison to normal marginal tissues. Moreover, the expression level of miR-34a was correlated with clinicopathological specifications of the patients.

Conclusions

miR-34a may be involved in the pathogenesis and development of esophageal cancer and have the potential to be used as a diagnostic and therapeutic marker in esophageal cancer.

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Titel: Expression Level of miR-34a in Tumor Tissue from Patients with Esophageal Squamous Cell Carcinoma
verfasst von: Milad Asadi
Dariush Shanehbandi
Hanieh Mohammadpour
Shahriyar Hashemzadeh
Bita Sepehri
Publikationsdatum: 17.02.2018
Verlag: Springer US
Erschienen in: Journal of Gastrointestinal Cancer / Ausgabe 2/2019
Print ISSN: 1941-6628
Elektronische ISSN: 1941-6636
DOI: https://doi.org/10.1007/s12029-018-0060-0

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Springer Medizin

Expression Level of miR-34a in Tumor Tissue from Patients with Esophageal Squamous Cell Carcinoma

Abstract

Background

Methods

Results

Conclusions

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Springer Medizin

Abstract

Background

Methods

Results

Conclusions

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