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01.12.2014 | Research article | Ausgabe 1/2014 Open Access

BMC Gastroenterology 1/2014

Expression of energy metabolism related genes in the gastric tissue of obese individuals with non-alcoholic fatty liver disease

Zeitschrift:
BMC Gastroenterology > Ausgabe 1/2014
Autoren:
Rohini Mehta, Aybike Birerdinc, Lei Wang, Zahra Younoszai, Amir Moazzez, Hazem Elariny, Zachary Goodman, Vikas Chandhoke, Ancha Baranova, Zobair M Younossi
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1471-230X-14-72) contains supplementary material, which is available to authorized users.
Rohini Mehta, Aybike Birerdinc, Ancha Baranova contributed equally to this work.

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

RM performed qPCRs and produced figures; ABir, ABar and RM wrote the manuscript; LW and RM performed statistical analysis; ZaY collected samples and performed chart reviews; AM and HE are bariatric surgeons who collected samples according to excusion and inclusion criteria; ZG reviewed and scored histological slides of the liver; ABar, ABir, VC and ZoY designed experiments and edited the manuscript. All authors read and approved the final manuscript.

Abstract

Background

Stomach is an integral part of the energy balance regulating circuit. Studies exploring the effects of cross-system changes in the energy homeostasis in stomach tissue are scarce. The proximity of the stomach to liver - the most common secondary target affected by obesity – suggests that these two organs are exposed to each other’s local secretion. Therefore, we aimed at expression profiling of energy metabolism associated genes in the gastric tissue of obese non-alcoholic fatty liver disease (NAFLD) patients.

Methods

A total of 24 patients with histologically-proven NAFLD were included. In the gastric tissue, gene expression profiling of 84 energy metabolism associated genes was carried out.

Results

The accumulation of the fat in the liver parenchyma is accompanied by downregulation of genes encoding for carboxypeptidase E (CPE) and Interleukin 1B (IL1B) in the gastric mucosa of same patient. In patients with high grade hepatic steatosis, Interleukin 1 beta encoding gene with anorexigenic function, IL1B was downregulated. The levels expression of 21 genes, including ADRA2B, CNR1 and LEP were significantly altered in the gastric tissue of NAFLD patients with hepatic inflammation. There were also indications of an increase in the opioid signaling within gastric mucosa that may results in a shift to proinflammatory environment within this organ and contribute to systemic inflammation and the pathogenic processes in hepatic parenchyma.

Conclusions

We have shown differential expression of energy metabolism associated genes in the gastric tissue of obese NAFLD patients. Importantly, these gene expression profiles are associated with changes in the hepatic parenchyma as reflected in increased scores for hepatic steatosis, inflammation, fibrosis and NASH. This study suggests the complex interplay of multiple organs in the pathogenesis of obesity-related complications such as NAFLD and provides further evidence supporting an important role for gastric tissue in promoting obesity-related complications.
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