Skip to main content
Erschienen in: Tumor Biology 4/2011

01.08.2011 | Research Article

Expression of ezrin correlates with poor prognosis of nasopharyngeal carcinoma

verfasst von: Liang Wang, Gui-Nan Lin, Xiang-Li Jiang, Yue Lu

Erschienen in: Tumor Biology | Ausgabe 4/2011

Einloggen, um Zugang zu erhalten

Abstract

A significant proportion of patients with nasopharyngeal carcinoma (NPC) will develop regional relapse or distant metastasis after treatment. So, to find valuable prognostic factors becomes very important. To elucidate the expression of ezrin in NPC and its correlation with patients’ clinicopathologic characteristics, time to progression, and overall survival, immunohistochemistry stains for ezrin were applied to 200 tissue specimens of NPC. Ezrin expression had no significant correlation with sex, age, primary tumor stage (T), Epstein–Barr virus (EBV) VCA-IgA antibody, EBV EA-IgA antibody, and EBV DNA copy except primary nodal status (N; p = .032). Increased ezrin expression was significantly related to higher lymph nodal metastatic rate (p < .004). Among ezrin negative/weak, ezrin moderate, and ezrin intense groups, there was a significant difference for median time to progression (not reached vs. 63.2 months vs. 46 months, P < .001) and median overall survival (100.7 months vs. 80.8 months vs. 70.6 months, P < .001). Ezrin expression status was an independent prognostic factor in multivariate (Cox) analysis. Ezrin, which was significantly correlated to prognosis of disease, may be involved in the tumorigenesis, progression, and invasion of NPC. Thus, our data offer the possibility of future therapeutic targets.
Literatur
1.
Zurück zum Zitat Chang ET, Adami H. The enigmatic epidemiology of nasopharyngeal carcinoma. Cancer Epidemiol Biomark Prev. 2006;15(10):1765–77.CrossRef Chang ET, Adami H. The enigmatic epidemiology of nasopharyngeal carcinoma. Cancer Epidemiol Biomark Prev. 2006;15(10):1765–77.CrossRef
2.
Zurück zum Zitat Hiscox S, Jiang WG, et al. Ezrin regulates cell-cell and cell-matrix adhesion, a possible role with E-cadherin/beta-catenin. J Cell Sci. 1999;112:3081–90.PubMed Hiscox S, Jiang WG, et al. Ezrin regulates cell-cell and cell-matrix adhesion, a possible role with E-cadherin/beta-catenin. J Cell Sci. 1999;112:3081–90.PubMed
3.
Zurück zum Zitat Mc Clatchey AI. Merlin and ERM proteins: unappreciated roles in cancer development. Nat Rev Cancer. 2003;3:877–83.CrossRef Mc Clatchey AI. Merlin and ERM proteins: unappreciated roles in cancer development. Nat Rev Cancer. 2003;3:877–83.CrossRef
4.
Zurück zum Zitat Vaheri A, Carp_en O, Heiska L, et al. The ezrin protein family: membrane–cytoskeleton interactions and disease associations. Curr Opin Cell Biol. 1997;9:659–66.PubMedCrossRef Vaheri A, Carp_en O, Heiska L, et al. The ezrin protein family: membrane–cytoskeleton interactions and disease associations. Curr Opin Cell Biol. 1997;9:659–66.PubMedCrossRef
5.
Zurück zum Zitat Ilmonen S, Vaheri A, Asko-Seljävaara S, et al. Ezrin in primary cutaneous melanoma. Mod Pathol. 2005;18:503–10.PubMedCrossRef Ilmonen S, Vaheri A, Asko-Seljävaara S, et al. Ezrin in primary cutaneous melanoma. Mod Pathol. 2005;18:503–10.PubMedCrossRef
6.
Zurück zum Zitat Xie J-J, Xu L-Y, Xie Y-M, et al. Roles of ezrin in the growth and invasiveness of esophageal squamous carcinoma cells. Int J Cancer. 2009;124:2549–58.PubMedCrossRef Xie J-J, Xu L-Y, Xie Y-M, et al. Roles of ezrin in the growth and invasiveness of esophageal squamous carcinoma cells. Int J Cancer. 2009;124:2549–58.PubMedCrossRef
7.
Zurück zum Zitat Elzagheid A, Korkeila E, Riyad, et al. Intense cytoplasmic ezrin immunoreactivity predicts poor survival in colorectal cancer. Hum Pathol. 2008;39:1737–43.PubMedCrossRef Elzagheid A, Korkeila E, Riyad, et al. Intense cytoplasmic ezrin immunoreactivity predicts poor survival in colorectal cancer. Hum Pathol. 2008;39:1737–43.PubMedCrossRef
8.
Zurück zum Zitat Mäkitie T, Carpen O, Vaheri A, et al. Ezrin as a prognostic indicator and its relationship to tumor characteristics in uveal malignant melanoma. Invest Ophthalmol Vis Sci. 2001;42:2442–9.PubMed Mäkitie T, Carpen O, Vaheri A, et al. Ezrin as a prognostic indicator and its relationship to tumor characteristics in uveal malignant melanoma. Invest Ophthalmol Vis Sci. 2001;42:2442–9.PubMed
9.
Zurück zum Zitat Wang L, Gao Y, Tu Q, et al. Expression of ezrin and E-cadherin in nasopharyngeal carcinoma and its significance. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2010;35(9):969–75.PubMed Wang L, Gao Y, Tu Q, et al. Expression of ezrin and E-cadherin in nasopharyngeal carcinoma and its significance. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2010;35(9):969–75.PubMed
10.
Zurück zum Zitat Böhling T, Turunen O, Jääskeläinen J, et al. Ezrin expression in stromal cells of capillary hemangioblastoma. An immunohistochemical survey of brain tumors. Am J Pathol. 1996;148:367–73.PubMed Böhling T, Turunen O, Jääskeläinen J, et al. Ezrin expression in stromal cells of capillary hemangioblastoma. An immunohistochemical survey of brain tumors. Am J Pathol. 1996;148:367–73.PubMed
11.
Zurück zum Zitat Ogino W, Takeshima Y, Mori T, et al. High level of ezrin mRNA expression in an osteosarcoma biopsy sample with lung metastasis. J Pediatr Hematol Oncol. 2007;7:435–9.CrossRef Ogino W, Takeshima Y, Mori T, et al. High level of ezrin mRNA expression in an osteosarcoma biopsy sample with lung metastasis. J Pediatr Hematol Oncol. 2007;7:435–9.CrossRef
12.
Zurück zum Zitat Andy J. Minn, Joan Massague, Invasion and metastasis. In: Devita, Hellman & Rosenberg’s Cancer: principles & practice of oncology, 8th ed. Philadelphia: Lippincott-Raven; 2008. p. 118–133 Andy J. Minn, Joan Massague, Invasion and metastasis. In: Devita, Hellman & Rosenberg’s Cancer: principles & practice of oncology, 8th ed. Philadelphia: Lippincott-Raven; 2008. p. 118–133
13.
Zurück zum Zitat Takeuchi K, Sato N, Kasahara H, et al. Perturbation of cell adhesion and microvilli formation by antisense oligonucleotides to ERM family members. J Cell Biol. 1994;125:1371–84.PubMedCrossRef Takeuchi K, Sato N, Kasahara H, et al. Perturbation of cell adhesion and microvilli formation by antisense oligonucleotides to ERM family members. J Cell Biol. 1994;125:1371–84.PubMedCrossRef
14.
Zurück zum Zitat Liotta LA, Tryggvason K, Garbisa S, et al. Metastatic potential correlates with enzymatic degradation of basement membrane collagen. Nature. 1980;284:67–8.PubMedCrossRef Liotta LA, Tryggvason K, Garbisa S, et al. Metastatic potential correlates with enzymatic degradation of basement membrane collagen. Nature. 1980;284:67–8.PubMedCrossRef
15.
Zurück zum Zitat Khanna C, Wan X, Bose S, et al. The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis. Nat Med. 2004;10:182–6.PubMedCrossRef Khanna C, Wan X, Bose S, et al. The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis. Nat Med. 2004;10:182–6.PubMedCrossRef
16.
Zurück zum Zitat Wan X, Mendoza A, Khanna C, et al. Rapamycin inhibits ezrin-mediated metastatic behavior in a murine model of osteosarcoma. Cancer Res. 2005;65:2406–11.PubMedCrossRef Wan X, Mendoza A, Khanna C, et al. Rapamycin inhibits ezrin-mediated metastatic behavior in a murine model of osteosarcoma. Cancer Res. 2005;65:2406–11.PubMedCrossRef
17.
Zurück zum Zitat Sarrió D, Rodríguez-Pinilla SM, et al. Abnormal ezrin localization is associated with clinicopathological features in invasive breast carcinomas. Breast Cancer Res Treat. 2006;1:71–9.CrossRef Sarrió D, Rodríguez-Pinilla SM, et al. Abnormal ezrin localization is associated with clinicopathological features in invasive breast carcinomas. Breast Cancer Res Treat. 2006;1:71–9.CrossRef
18.
Zurück zum Zitat Ferrari S, Zanella L, et al. Prognostic significance of immunohistochemical expression of ezrin in non-metastatic high-grade osteosarcoma. Pediatr Blood Cancer. 2008;50:752–6.PubMedCrossRef Ferrari S, Zanella L, et al. Prognostic significance of immunohistochemical expression of ezrin in non-metastatic high-grade osteosarcoma. Pediatr Blood Cancer. 2008;50:752–6.PubMedCrossRef
19.
Zurück zum Zitat Bretscher A, Edwards K, Fehon RG. ERM proteins and merlin: Integrators at the cell cortex. Nat Rev Mol Cell Biol. 2002;3:586–99.PubMedCrossRef Bretscher A, Edwards K, Fehon RG. ERM proteins and merlin: Integrators at the cell cortex. Nat Rev Mol Cell Biol. 2002;3:586–99.PubMedCrossRef
20.
Zurück zum Zitat Endo K, Kondo S, Shackleford J, et al. Phosphorylated ezrin is associated with EBV latent membrane protein 1 in nasopharyngeal carcinoma and induces cell migration. Oncogene. 2009;28:1725–35.PubMedCrossRef Endo K, Kondo S, Shackleford J, et al. Phosphorylated ezrin is associated with EBV latent membrane protein 1 in nasopharyngeal carcinoma and induces cell migration. Oncogene. 2009;28:1725–35.PubMedCrossRef
21.
Zurück zum Zitat Madan R, Brandwein-Gensler M, et al. Differential tissue and subcellular expressionof ERM proteins in normal and malignant tissues: cytoplasmic ezrin expression has prognostic signficance for head and neck squamous cell carcinoma. Head Neck. 2006;11:1018–27.CrossRef Madan R, Brandwein-Gensler M, et al. Differential tissue and subcellular expressionof ERM proteins in normal and malignant tissues: cytoplasmic ezrin expression has prognostic signficance for head and neck squamous cell carcinoma. Head Neck. 2006;11:1018–27.CrossRef
22.
Zurück zum Zitat Liu SJ, Sun YM, Tian DF, et al. Downregulated NM23-H1 expression is associated with intracranial invasion of nasopharyngeal carcinoma. Br J Cancer. 2008;98:363–9.PubMedCrossRef Liu SJ, Sun YM, Tian DF, et al. Downregulated NM23-H1 expression is associated with intracranial invasion of nasopharyngeal carcinoma. Br J Cancer. 2008;98:363–9.PubMedCrossRef
Metadaten
Titel
Expression of ezrin correlates with poor prognosis of nasopharyngeal carcinoma
verfasst von
Liang Wang
Gui-Nan Lin
Xiang-Li Jiang
Yue Lu
Publikationsdatum
01.08.2011
Verlag
Springer Netherlands
Erschienen in
Tumor Biology / Ausgabe 4/2011
Print ISSN: 1010-4283
Elektronische ISSN: 1423-0380
DOI
https://doi.org/10.1007/s13277-011-0171-8

Weitere Artikel der Ausgabe 4/2011

Tumor Biology 4/2011 Zur Ausgabe

Update Onkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.