Erschienen in:
24.11.2016 | Brief Report
Expression of human endogenous retrovirus K and W in babies
verfasst von:
L. H. S. Nali, A. C. S. Oliveira, D. O. Alves, G. S. Caleiro, C. F. Nunes, D. Gerhardt, R. C. M. Succi, Camila M. Romano, D. M. Machado
Erschienen in:
Archives of Virology
|
Ausgabe 3/2017
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Abstract
Here we determined the relative expression of HERV-K and W proviruses in HIV infected and non-infected mothers as well as their respective babies up to 1 year-old. HIV-infected mothers, their babies and uninfected control groups presented expression of both HERV-K and HERV-W with relatively high frequency. While the level of HERV-K expression was similar among groups, the level of HERV-W expression in HIV-infected mothers was four-fold higher than the uninfected mothers from the control group (p < 0.01). HERV-W was down regulated in HIV-exposed babies in comparison to non-exposed babies. To our knowledge, this is the first report of HERV transcriptional activity in babies from 0-1 year-old.