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European Archives of Oto-Rhino-Laryngology

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21.06.2016 | Head and Neck

Expression of the CXCL12/CXCR4 chemokine axis predicts regional control in head and neck squamous cell carcinoma

verfasst von: Xavier León, Santiago Diez, Jacinto García, Joan Lop, Anna Sumarroca, Miquel Quer, Mercedes Camacho

Erschienen in: European Archives of Oto-Rhino-Laryngology | Ausgabe 12/2016

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Abstract

Expression of the CXCL12/CXCR4 chemokine axis has been related with the appearance of metastatic recurrence survival, including regional and distant recurrence, in patients with head and neck squamous cell carcinoma (HNSCC). RT-PCR was used to determine mRNA expression levels of CXCL12 and CXCR4 in biopsy tumor samples in 111 patients with HNSCC. Five-year regional recurrence-free survival for patients with low CXCR4 expression (n = 39, 31.5 %) was 97.4 %, for patients with high CXCR4/high CXCL12 expression (n = 22, 19.8 %) it was 94.7 %, and for patients with high CXCR4/low CXCL12 expression (n = 50, 45.0 %) it was 63.3 %. We found significant differences in the regional recurrence-free survival according to CXCR4/CXCL12 expression values (P = 0.001). HNSCC patients with high CXCR4 and low CXCL12 expression values had a significantly higher risk of regional recurrence and could benefit from a more intense treatment of lymph node areas in the neck.

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Titel: Expression of the CXCL12/CXCR4 chemokine axis predicts regional control in head and neck squamous cell carcinoma
verfasst von: Xavier León
Santiago Diez
Jacinto García
Joan Lop
Anna Sumarroca
Miquel Quer
Mercedes Camacho
Publikationsdatum: 21.06.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: European Archives of Oto-Rhino-Laryngology / Ausgabe 12/2016
Print ISSN: 0937-4477
Elektronische ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-016-4144-9

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Expression of the CXCL12/CXCR4 chemokine axis predicts regional control in head and neck squamous cell carcinoma

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