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Journal of Cancer Research and Clinical Oncology

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01.04.2010 | Original Paper

Expression status of Zic family member 2 as a prognostic marker for oral squamous cell carcinoma

verfasst von: Kentaro Sakuma, Atsushi Kasamatsu, Masanobu Yamatoji, Yukio Yamano, Kazuaki Fushimi, Manabu Iyoda, Kenji Ogoshi, Keiji Shinozuka, Katsunori Ogawara, Masashi Shiiba, Hideki Tanzawa, Katsuhiro Uzawa

Erschienen in: Journal of Cancer Research and Clinical Oncology | Ausgabe 4/2010

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Abstract

Purpose

To determine the involvement of ZIC2 in oral squamous cell carcinoma (OSCC).

Methods

ZIC2 mRNA and protein expression in primary OSCCs (n = 74), oral premalignant lesions (OPLs, n = 20) and five OSCC-derived cell lines (HSC-2, HSC-3, OK-92, H1, and Sa3) were analyzed by quantitative reverse transcriptase-polymerase chain reaction, Western blot and immunohistochemistry (IHC). In addition, we evaluated the correlation between ZIC2 IHC scores in OSCCs and the clinicopathologic status.

Results

Significant up-regulation of ZIC2 was detected in OSCC-derived cell lines (P < 0.05), primary OSCCs (P < 0.05) and OPLs (P < 0.05) compared with normal counterparts. Among the clinical variables analyzed, ZIC2 expression was associated with the histopathologic types of OSCC. Furthermore, the survival rates differed significantly between ZIC2-positive cases and ZIC2-negative cases.

Conclusions

These results suggested that ZIC2 expression is correlated with the differentiation type of OSCC and diagnosis and might be a potential prognostic indicator and therapeutic target for OSCCs.

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Titel: Expression status of Zic family member 2 as a prognostic marker for oral squamous cell carcinoma
verfasst von: Kentaro Sakuma
Atsushi Kasamatsu
Masanobu Yamatoji
Yukio Yamano
Kazuaki Fushimi
Manabu Iyoda
Kenji Ogoshi
Keiji Shinozuka
Katsunori Ogawara
Masashi Shiiba
Hideki Tanzawa
Katsuhiro Uzawa
Publikationsdatum: 01.04.2010
Verlag: Springer-Verlag
Erschienen in: Journal of Cancer Research and Clinical Oncology / Ausgabe 4/2010
Print ISSN: 0171-5216
Elektronische ISSN: 1432-1335
DOI: https://doi.org/10.1007/s00432-009-0689-y

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23.04.2024 | Medikamente in Schwangerschaft und Stillzeit | Nachrichten

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Expression status of Zic family member 2 as a prognostic marker for oral squamous cell carcinoma

Abstract

Purpose

Methods

Results

Conclusions

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ICI-Therapie in der Schwangerschaft wird gut toleriert

Krebspatienten impfen: Was? Wen? Und wann nicht?

Müde im Alter? Auch an die Nebenniere denken

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Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusions

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