Erschienen in:
15.09.2016 | Correspondence
Extended post-mortem delay times should not be viewed as a deterrent to the scientific investigation of human brain tissue: a study from the Brains for Dementia Research Network Neuropathology Study Group, UK
verfasst von:
Andrew C. Robinson, Laura Palmer, Seth Love, Marie Hamard, Margaret Esiri, Olaf Ansorge, Debbie Lett, Johannes Attems, Chris Morris, Claire Troakes, Sashika Selvackadunco, Andrew King, Safa Al-Sarraj, David M. A. Mann
Erschienen in:
Acta Neuropathologica
|
Ausgabe 5/2016
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Excerpt
Although animal and cellular models can recapitulate certain aspects of the pathology and pathogenesis of human neurodegenerative diseases such as Alzheimer’s disease, frontotemporal lobar degeneration and Parkinson’s disease, none of these models is perfect. The study of human post-mortem tissues is still essential for investigation of neurodegenerative disorders. It is a common perception that the long post-mortem delays (PMDs) that often limit the acquisition of brains after death are detrimental to brain quality, and therefore, prejudicial to the reliability of scientific data based on such materials. However, this viewpoint is largely anecdotal and has not been supported by scientific evidence. We have sought to address this issue by investigating how putative measures of tissue quality such as brain pH or values of RNA integrity (RIN) relate to PMD. …
