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European Journal of Epidemiology

Erschienen in:

19.06.2019 | COMMENTARY

Extending inferences from a randomized trial to a target population

verfasst von: Issa J. Dahabreh, Miguel A. Hernán

Erschienen in: European Journal of Epidemiology | Ausgabe 8/2019

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In this issue, Weiss discusses “generalizing” inferences from randomized trials to other populations [1]. However, he does not explicitly define what “generalizing” means, assumes that “generalizing” the results of a randomized trial has a single goal, and reduces generalizability to a binary subjective judgment—findings are either generalizable or not generalizable. A growing literature (e.g., [1‐13]) precisely defines the several meanings and goals of extending inferences from randomized trials to another population, and describes analyses whose findings go beyond simple binary judgements. Here, we provide a non-technical overview of this literature. First, we briefly review the main concepts, then we outline the available study designs and statistical approaches. …

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Dahabreh IJ, Robins JM, Haneuse SJ, Hernán MA. Generalizing causal inferences from randomized trials: counterfactual and graphical identification. 2019 (forthcoming).

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Nguyen TQ, Ebnesajjad C, Cole SR, Stuart EA. Sensitivity analysis for an unobserved moderator in RCT-to-target-population generalization of treatment effects. Ann Appl Stat. 2017;11(1):225–47.CrossRef

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Nguyen TQ, Ackerman B, Schmid I, Cole SR, Stuart EA. Sensitivity analyses for effect modifiers not observed in the target population when generalizing treatment effects from a randomized controlled trial: assumptions, models, effect scales, data scenarios, and implementation details. PLoS ONE. 2018;13(12):e0208795. https://doi.org/10.1371/journal.pone.0208795.CrossRefPubMedPubMedCentral

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Titel: Extending inferences from a randomized trial to a target population
verfasst von: Issa J. Dahabreh
Miguel A. Hernán
Publikationsdatum: 19.06.2019
Verlag: Springer Netherlands
Erschienen in: European Journal of Epidemiology / Ausgabe 8/2019
Print ISSN: 0393-2990
Elektronische ISSN: 1573-7284
DOI: https://doi.org/10.1007/s10654-019-00533-2

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Extending inferences from a randomized trial to a target population

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