External validation of the "optimal PSA follow-up schedule after radical prostatectomy” in a new cohort
- 13.04.2020
- Original Article
Erschienen in:
- Verfasst von
- Yoshinori Yanai
- Kazuhiro Matsumoto
- Takeo Kosaka
- Toshikazu Takeda
- Nobuyuki Tanaka
- Shinya Morita
- Ryuichi Mizuno
- Toshiaki Shinojima
- Hiroshi Asanuma
- Mototsugu Oya
- Erschienen in
- International Journal of Clinical Oncology | Ausgabe 7/2020
Abstract
Background
Biochemical recurrence (BCR) after radical prostatectomy (RP) is most commonly diagnosed by detecting an increase in asymptomatic prostate-specific antigen (PSA). We previously reported the “optimal PSA follow-up schedule after RP”. The aim of this study was to confirm the usefulness and safety of that follow-up schedule in another cohort.
Methods
We retrospectively reviewed the clinicopathological data of 798 consecutive patients who underwent radical prostatectomy between 2009 and 2017. We examined all PSA values measured during follow-up. Furthermore, we estimated the PSA value when we observed the “optimal PSA follow-up schedule” at each timing in the virtual follow-up. BCR was defined as an elevation of PSA to greater than 0.2 ng/ml, and the ideal PSA range for detection of BCR was regarded to be 0.2–0.4 ng/ml.
Results
During the mean follow-up period of 5.8 years, BCR occurred in 115 (14.9%) patients and the frequency of virtual follow-up was significantly lower than the actual frequency. However, overlooking of BCR (detecting BCR when PSA exceeded 0.4 ng/ml) was observed in 17 patients, which is higher than the actual frequency of overlooking (12 patients). Therefore, we modified the follow-up schedule, which could achieve the lower follow-up frequency and a limited number of overlooking of BCR (7 patients).
Conclusion
This external validation study revealed that the "modified optimal PSA follow-up schedule after RP" can reduce the frequency of PSA measurement with a limited risk of overlooking BCR.
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- Titel
- External validation of the "optimal PSA follow-up schedule after radical prostatectomy” in a new cohort
- Verfasst von
-
Yoshinori Yanai
Kazuhiro Matsumoto
Takeo Kosaka
Toshikazu Takeda
Nobuyuki Tanaka
Shinya Morita
Ryuichi Mizuno
Toshiaki Shinojima
Hiroshi Asanuma
Mototsugu Oya
- Publikationsdatum
- 13.04.2020
- Verlag
- Springer Singapore
- Erschienen in
-
International Journal of Clinical Oncology / Ausgabe 7/2020
Print ISSN: 1341-9625
Elektronische ISSN: 1437-7772 - DOI
- https://doi.org/10.1007/s10147-020-01676-z
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