Background
Results
Detection of BART miRNAs in xenografted NPC tumors
Detection of BART miRNAs in exosomes released by NPC cells in vitro
Detection of BART miRNAs in the plasma of xenografted NPC- bearing mice
C15 | C666-1 | C17 | CAPI | ||
---|---|---|---|---|---|
Tumor mass/Body mass (average ratio)
| 6%-8% | 6%-8% | 6%-8% | 6%-8% | |
Plasma DNA viral load (copies/ml)
| 6298 | 6298 | 50989 | < 200 | |
2
-ΔCt
|
ebv-miR-BART5
| 1.516 | 1.542 | < 10-4 | < 10-4 |
ebv-miR-BART7-3p
| 13.017 | 16.66 | 0.173 | 0.009 | |
ebv-miR-BART13
| 2.329 | 1.79 | 0.555 | 0.001 |
Detection of BART miRNAs in the plasma of NPC patients
Patient code | Age-sex- Country of origin | Tumor histological type (1) | Clinical Staging (2) | EBV status | Plasma viral DNA load (copies/ml) (3) | Ebv-miR-BART 7-3p 2 -ΔCt X1000 | ||
---|---|---|---|---|---|---|---|---|
EBER detection on tumor sections (3) | EBV serology Positive if > 0.2 Negative if < 0.1 (3) | |||||||
NPC PATIENTS | EXO 14 | 52-M-Vietnam | Non-keratinizing Undifferentiated | T3N3M1 | EBER+ | Not tested | 4202 |
250,5
|
EXO 22 | 51-M-France | Non-keratinizing undifferentiated | T3N2M1 | EBER + | Not tested | 1142 |
2360,3
| |
HEP 1 | 45-M-Cambodia | Non-keratinizing undifferentiated | T1N2M0 | EBER + | Not tested | < 200 |
6
| |
EXO 32 | 40-F-Madagascar | Non-keratinizing undifferentiated | T3N2M0 | EBER+ | Not tested | < 200 |
329,9
| |
HEP 2 | 58-M-France | Non-keratinizing undifferntiated | T3N1M0 | EBER+ | Not tested | 1589 |
502,1
| |
NON-NPC TUMOR CARRIERS | HEP 5 | 69-M- France | Adenocarcinoma Multiple bone metastases of unknown primary | Not Applicable (NA) | NA | Anti-EBNA: 0,41 Anti-VCA: 4,08 | < 200 |
3,47
|
HEP 10 | 63-M-France | Larynx squamous cell carcinoma | T4N2M0 | NA | Anti-EBNA:7,13 Anti-VCA: 3,73 | < 200 |
57,5
| |
HEALTHY CONTROLS | TBS 1 | 53-M-Algeria | NA | NA | NA | Anti-EBNA: 2,79 Anti-VCA: 2,46 | < 200 |
37,7
|
TBS 2 | 34-F-France | NA | NA | NA | Anti-EBNA: 0,07 Anti-VCA: 4,57 | < 200 |
3,47
| |
TBS 3 | 29-F-France | NA | NA | NA | Anti-EBNA: 5,56 Anti-VCA: 1,65 | < 200 |
79,8
| |
TBS 4 | 25-M-France | NA | NA | NA | Anti-EBNA: 0,05 Anti-VCA: 0 | < 200 |
99
|