Extracardiac findings with increased perfusion during clinical O-15-H2O PET/CT myocardial perfusion imaging: A case series
- 05.01.2023
- ORIGINAL ARTICLE
Erschienen in:
- Verfasst von
- Mads Ryø Jochumsen, MD, PhD
- David Lyse Overgaard, MD
- Mikkel Holm Vendelbo, MD, PhD
- Michael Alle Madsen, MD, PhD
- Lars Poulsen Tolbod, MSc, PhD
- Lars Christian Gormsen, MD, PhD
- Trine Ørhøj Barkholt, MD, PhD
- Erschienen in
- Journal of Nuclear Cardiology | Ausgabe 4/2023
Abstract
Background
Coincidental extracardiac findings with increased perfusion were reported during myocardial perfusion imaging (MPI) with various retention radiotracers. Clinical parametric O-15-H2O PET MPI yielding quantitative measures of myocardial blood flow (MBF) was recently implemented at our facility. We aim to explore whether similar extracardiac findings are observed using O-15-H2O.
Methods and results
All patients (2963) were scanned with O-15-H2O PET MPI according to international guidelines and extracardiac findings were collected. In contrast to parametric O-15-H2O MBF images, extracardiac perfusion was assessed using summed images. Biopsy histopathology and other imaging modalities served as reference standards. Various malignant lesions with increased perfusion were detected, including lymphomas, large-celled neuroendocrine tumour, breast, and lung cancer plus metastases from colonic and renal cell carcinomas. Furthermore, inflammatory and hyperplastic benign conditions with increased perfusion were observed: rib fractures, gynecomastia, atelectasis, sarcoidosis, pneumonia, chronic lung inflammation and fibrosis, benign lung nodule, chronic diffuse lung infiltrates, pleural plaques and COVID-19 infiltrates.
Conclusions
Malignant and benign extracardiac coincidental findings with increased perfusion are readily visible and frequently seen on O-15-H2O PET MPI. We recommend evaluating the summed O-15-H2O PET images in addition to the low-dose CT attenuation images.
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- Titel
- Extracardiac findings with increased perfusion during clinical O-15-H2O PET/CT myocardial perfusion imaging: A case series
- Verfasst von
-
Mads Ryø Jochumsen, MD, PhD
David Lyse Overgaard, MD
Mikkel Holm Vendelbo, MD, PhD
Michael Alle Madsen, MD, PhD
Lars Poulsen Tolbod, MSc, PhD
Lars Christian Gormsen, MD, PhD
Trine Ørhøj Barkholt, MD, PhD
- Publikationsdatum
- 05.01.2023
- Verlag
- Springer International Publishing
- Erschienen in
-
Journal of Nuclear Cardiology / Ausgabe 4/2023
Print ISSN: 1071-3581
Elektronische ISSN: 1532-6551 - DOI
- https://doi.org/10.1007/s12350-022-03156-5
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