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Journal of Cardiovascular Translational Research
Erschienen in: Journal of Cardiovascular Translational Research 2/2020

29.10.2019 | Review

Extracellular Vesicles as Messengers in Atherosclerosis

verfasst von: Mengna Peng, Xinfeng Liu, Gelin Xu

Erschienen in: Journal of Cardiovascular Translational Research | Ausgabe 2/2020

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Abstract

Atherosclerosis is a major cause of cardiovascular diseases. Most cells involved in atherosclerosis can shed extracellular vesicles (EVs). Both atherogenic factors, such as hypoxia and oxidative stress, and atheroprotective factors, such as laminar blood flow, can influence the production of EV shedding. EVs can carry protein, DNA, mRNA, and noncoding RNA and act as mediators or messengers for cell-to-cell communications. EVs have been proven to promote or inhibit atherogenesis under particular circumstances. Therefore, EVs might be targeted for preventing or treating atherosclerotic diseases. The level of circulating EVs has been associated with the presence, progressiveness, or severity of atherosclerosis. Therefore, EVs may be utilized as indexes for diagnosing and grading atherosclerosis. Here, we reviewed the progress concerning the involvements of EVs in atherogenesis and atheroprotection. We also discussed the potential applications of EVs in managing atherosclerotic diseases.
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Metadaten
Titel
Extracellular Vesicles as Messengers in Atherosclerosis
verfasst von
Mengna Peng
Xinfeng Liu
Gelin Xu
Publikationsdatum
29.10.2019
Verlag
Springer US
Erschienen in
Journal of Cardiovascular Translational Research / Ausgabe 2/2020
Print ISSN: 1937-5387
Elektronische ISSN: 1937-5395
DOI
https://doi.org/10.1007/s12265-019-09923-z

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