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Targeted Oncology
Erschienen in: Targeted Oncology 2/2018

26.01.2018 | Review Article

Extracellular Vesicles As miRNA Nano-Shuttles: Dual Role in Tumor Progression

verfasst von: Marzia Pucci, Pablo Reclusa Asiáin, Elena Duréndez Sáez, Eloisa Jantus-Lewintre, Mahafarin Malarani, Shahanavaj Khan, Simona Fontana, Aung Naing, Francesco Passiglia, Luis E. Raez, Christian Rolfo, Simona Taverna

Erschienen in: Targeted Oncology | Ausgabe 2/2018

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Abstract

Tumor-derived extracellular vesicles (EVs) have a pleiotropic role in cancer, interacting with target cells of the tumor microenvironment, such as fibroblasts, immune and endothelial cells. EVs can modulate tumor progression, angiogenic switch, metastasis, and immune escape. These vesicles are nano-shuttles containing a wide spectrum of miRNAs that contribute to tumor progression. MiRNAs contained in extracellular vesicles (EV-miRNAs) are disseminated in the extracellular space and are able to influence the expression of target genes with either tumor suppressor or oncogenic functions, depending on both parental and target cells. Metastatic cancer cells can balance their oncogenic potential by expressing miRNAs with oncogenic function, whilst exporting miRNAs with tumor suppressor roles out of the cells. Importantly, treatment of cancer cells with specific natural and chemical compounds could induce the elimination of miRNAs with oncogenic function, thereby reducing their aggressiveness. In this review, we discuss the mechanisms by which EV-miRNAs, acting as miRNAs with oncogenic or tumor suppressor functions, could contribute to cancer progression.
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Metadaten
Titel
Extracellular Vesicles As miRNA Nano-Shuttles: Dual Role in Tumor Progression
verfasst von
Marzia Pucci
Pablo Reclusa Asiáin
Elena Duréndez Sáez
Eloisa Jantus-Lewintre
Mahafarin Malarani
Shahanavaj Khan
Simona Fontana
Aung Naing
Francesco Passiglia
Luis E. Raez
Christian Rolfo
Simona Taverna
Publikationsdatum
26.01.2018
Verlag
Springer International Publishing
Erschienen in
Targeted Oncology / Ausgabe 2/2018
Print ISSN: 1776-2596
Elektronische ISSN: 1776-260X
DOI
https://doi.org/10.1007/s11523-018-0551-8

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