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Erschienen in: Archives of Orthopaedic and Trauma Surgery 8/2011

01.08.2011 | Basic Science

Extracorporeal shockwave therapy shows chondroprotective effects in osteoarthritic rat knee

verfasst von: Ching-Jen Wang, Lin-Hsiu Weng, Jih-Yang Ko, Yi-Chih Sun, Ya-Ju Yang, Feng-Sheng Wang

Erschienen in: Archives of Orthopaedic and Trauma Surgery | Ausgabe 8/2011

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Abstract

Purpose

This study investigated the effects of extracorporeal shockwave therapy (ESWT) on the subchondral bone and articular cartilage in the initiation of osteoarthritis of the knee in rats.

Methods

Anterior cruciate ligament transected (ACLT) osteoarthritis (OA) rat knee model was used in this study. Twenty-seven male Sprague-Dawley rats were divided into three groups. The control group underwent sham surgery without ACLT and received no ESWT. The ACLT group underwent ACLT, but received no ESWT. The ACLT plus ESWT group underwent ACLT and received ESWT immediately after surgery. The evaluation parameters included radiograph, bone mineral density, serum levels of cartilage oligometric protein and osteocalcin, and urinary concentration of C-telopeptide of type II collagen (CTX-II), and histomorphological examination.

Results

At 12 weeks, OA of the knee was radiographically verified in the ACLT group, but very subtle changes were noticed in the control and the ACLT plus ESWT groups. On articular cartilage, the ACLT group showed significant increases in cartilage degradation and chondrocyte apoptosis compared to the control and ACLT plus ESWT groups. The ACLT plus ESWT group demonstrated significant decrease in the cartilage degradation and an increase in chondrocyte activity comparable to the control. In subchondral bone, the ACLT group showed a significant decrease in bone remodeling as compared to the control and ACLT plus ESWT groups. The ACLT plus ESWT group showed significant improvement in bone remodeling comparable to the control.

Conclusion

Extracorporeal shockwave therapy shows chondroprotective effect associated with improvement in subchondral bone remodeling in the initiation of ACLT OA knee model in rats.
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Metadaten
Titel
Extracorporeal shockwave therapy shows chondroprotective effects in osteoarthritic rat knee
verfasst von
Ching-Jen Wang
Lin-Hsiu Weng
Jih-Yang Ko
Yi-Chih Sun
Ya-Ju Yang
Feng-Sheng Wang
Publikationsdatum
01.08.2011
Verlag
Springer-Verlag
Erschienen in
Archives of Orthopaedic and Trauma Surgery / Ausgabe 8/2011
Print ISSN: 0936-8051
Elektronische ISSN: 1434-3916
DOI
https://doi.org/10.1007/s00402-011-1289-2

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