The online version of this article (doi:10.1186/1477-7819-10-69) contains supplementary material, which is available to authorized users.
The authors declare that they have no competing interests.
IL and HA performed the literature review, composed the case report and wrote the manuscript. MA and AB were involved with conception and design and collection and assembly of data. BEK and MA analyzed and interpreted the anatomopathology findings. SB, NB and ME approved the final manuscript. All authors read and approved the final manuscript.
Extragonadal localization of germ cell tumors (GCTs) is rare; to the best of our knowledge, a location in the soft tissue of the arm has never been previously reported in the literature.
We report the case of a 37-year-old man who presented with a primary malignant mixed non-seminomatous GCT (teratocarcinoma variety) in the right arm, treated by a combination of cisplatin-based chemotherapy and surgery. After 18 months of close follow-up, no locoregional recurrence or distant metastases have been detected.
A combination of chemotherapy and surgery is the most appropriate treatment strategy for extragonadal GCTs, to ensure both local and systemic control.
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Droz JP, Horwich A: Extragonadal germ cell tumors. Comprehensive Textbook of Genitourinary Oncology. Edited by: Vogelzang NJ, Scardino PT, Shipley WU, Doffey DS. 2000, Lippincott Williams and Wilkins, New York, NY, 2
Morse MJ, Whitmore WF: Neoplasms of the testis. Campbell’s Urology. Edited by: Walsh PC, Gittes RF, Perlmutter AD, Stamey TA. 1986, WB Saunders Co, Philadelphia, PA, 1535-5
Buskirk SS, Evans RG, Farrow G, Earle JP: Primary retroperitoneal seminoma. Cancer. 1934, 1982: 49-
Chinoy RF, Soman CS, Swaroop D, Badwar RA: Extragonadal malignant teratoma of the foot. Indian J Cancer. 1992, 29: 96-99. PubMed
Chaganti RS, Houldsworth J: Genetics and biology of adult human male germ cell tumors. Cancer Res. 2000, 60: 1475- PubMed
Chen CK, Chang YL, Jou ST, Tseng YT, Lee YC: Treatment of mediastinal immature teratoma in a child with precocious puberty and Klinefelter’s syndrome. Ann Thorac Surg. 1906, 2006: 82-
Gonzalez-Crussi F: Extragonadal teratomas. Atlas of Tumor Pathology. Volume 18. Edited by: Hartmann WH, Cowan WR. 1982, Armed Forces Institute of Pathology, Washington, DC, 1-49.
Bšhle A, Studer UE, Sonntag RW, Scheidegger JR: Primary or secondary extragonadal germ cell tumors?. J Urol. 1986, 135: 939-
Cheng L: Establishing a germ cell origin for metastatic tumors using OCT4 immunohistochemistry. Cancer. 2006, 2004: 101-
Motzer RJ, Rodriguez E, Reuter VE, Bosl GJ, Mazumdar M, Chaganti RS: Molecular and cytogenetic studies in the diagnosis of patients with poorly differentiated carcinomas of unknown primary site. J Clin Oncol. 1995, 13: 274- PubMed
Travis WD, Brambilla E, Muller-Hermerlink HK, Harris CC: World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart. 2004, IARC Press, Lyon, France
Wright CD, Kesler KA, Nichols CR: Primary mediastinal non seminomatous germ cell tumors, Results of a multimodality approach. J Thorac Cardiovasc Surg. 1990, 99: 210-217. PubMed
- Extragonadal mixed germ cell tumor of the right arm: description of the first case in the literature
Hicham Ait Benali
- BioMed Central
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