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Cancer Causes & Control
Erschienen in:

23.10.2021 | Original Paper

Eye color and the risk of skin cancer

verfasst von: Yueyao Li, Wen-Qing Li, Tricia Li, Abrar A. Qureshi, Eunyoung Cho

Erschienen in: Cancer Causes & Control | Ausgabe 1/2022

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Abstract

Melanoma, basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are the most common skin cancers. The incidence rates of all three types of skin cancers have increased in the past three decades. Light pigmentary traits have been recognized as one of the host risk factors for skin cancer, but findings on associations between eye colors and risk of skin cancers have been inconsistent.
We performed a prospective analysis to examine the association between eye colors and risk of skin cancers using the Health Professionals Follow-up Study (HPFS). Cox proportional hazard models were applied to estimate relative risks (RRs) and their 95% confidence intervals (CIs). Effect modifications due to hair color and skin reaction to sun were also examined.
The HPFS included 35,662 males. During a median follow-up of 19 years (1988–2012), 445 melanoma, 1123 SCC, and 7198 BCC cases were documented. Compared to those whose eye colors were dark or brown, participants with hazel/green/medium and blue/light colors had a 24% (RR = 1.24, 95% CI: 1.06–1.45) and a 19% (RR = 1.19, 95% CI: 1.01–1.41) higher risk of SCC, respectively. Similarly, a higher risk of BCC was observed in participants with hazel/green/medium eye colors (RR = 1.16, 95% CI: 1.09–1.23) and blue/light eye colors (RR = 1.17, 95% CI: 1.10–1.25). We did not find significant associations between eye color and risk of melanoma. Lighter eye color was associated with increased risks of SCC and BCC among those with dark hair colors (p for interaction ≤ 0.02).
In conclusion, in this large prospective study of men, we found that light eye colors were associated with higher risks of SCC and BCC, but not melanoma. Further studies are needed to confirm this association in other populations.
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Metadaten
Titel
Eye color and the risk of skin cancer
verfasst von
Yueyao Li
Wen-Qing Li
Tricia Li
Abrar A. Qureshi
Eunyoung Cho
Publikationsdatum
23.10.2021
Verlag
Springer International Publishing
Erschienen in
Cancer Causes & Control / Ausgabe 1/2022
Print ISSN: 0957-5243
Elektronische ISSN: 1573-7225
DOI
https://doi.org/10.1007/s10552-021-01508-z

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