Skip to main content
Erschienen in: Journal of Neurology 5/2009

01.05.2009 | Original Communication

Eye-movement training-induced plasticity in patients with post-stroke hemianopia

verfasst von: Gereon Nelles, Anja Pscherer, Armin de Greiff, Michael Forsting, Horst Gerhard, Joachim Esser, H. Christoph Diener

Erschienen in: Journal of Neurology | Ausgabe 5/2009

Einloggen, um Zugang zu erhalten

Abstract

Substantial disability in patients with hemianopia results from reduced visual perception. Previous studies have shown that these patients have impaired saccades. Improving exploratory eye movements with appropriate training of saccades may help to partially compensate for the visuoperceptive impairment during daily life activities. The changes in cortical control of eye movements that may be induced by these training strategies, however, are not known. We used functional magnetic resonance imaging (fMRI) to study the training effects of eye-movement training on cortical control of saccades. Brain activation during visually guided saccades was measured in eight patients with an occipital cortical lesion causing homonymous hemianopia. Starting 8 weeks after the stroke, patients received 4 weeks of visual field training. The fMRI measurements were performed at baseline and after training. In five patients, follow-up fMRI was performed 4 weeks after the end of training. Differences in activation between rest and saccades as well as before and after training were assessed with statistical parametric mapping software (SPM’99). Twelve healthy subjects were scanned twice at a 4-week interval. In patients, significant activation at baseline was found in the frontal and parietal eye fields (FEF and PEF, respectively) bilaterally and in the supplementary eye field (SEF). Immediately after training, an area of increased activation was found in the left extrastriate cortex of the affected hemisphere. At follow-up, relatively more activation was found in the right peristriate cortex and in the SEF of the unaffected side. A relative decrease of activation was found in the left FEF. In this group of patients, eye-movement training induced altered brain activation in the striate and extrastriate cortex as well as in oculomotor areas.
Literatur
1.
Zurück zum Zitat Zihl J (1995) Visual scanning behavior in patients with homonymous hemianopia. Neuropsychologia 33:287–303PubMedCrossRef Zihl J (1995) Visual scanning behavior in patients with homonymous hemianopia. Neuropsychologia 33:287–303PubMedCrossRef
2.
Zurück zum Zitat Kasten E, Wust S, Behrens-Baumann W, Sabel BA (1998) Computer-based training for the treatment of partial blindness. Nat Med 4:1083–1087PubMedCrossRef Kasten E, Wust S, Behrens-Baumann W, Sabel BA (1998) Computer-based training for the treatment of partial blindness. Nat Med 4:1083–1087PubMedCrossRef
3.
Zurück zum Zitat Kasten E, Bunzenthal U, Sabel BA (2006) Visual field recovery after vision restoration therapy (VRT) is independent of eye movements: an eye tracker study. Behav Brain Res 175:18–26PubMedCrossRef Kasten E, Bunzenthal U, Sabel BA (2006) Visual field recovery after vision restoration therapy (VRT) is independent of eye movements: an eye tracker study. Behav Brain Res 175:18–26PubMedCrossRef
4.
Zurück zum Zitat Kerkhoff G, Munssinger U, Meier EK (1994) Neurovisual rehabilitation in cerebral blindness. Arch Neurol 51:474–481PubMed Kerkhoff G, Munssinger U, Meier EK (1994) Neurovisual rehabilitation in cerebral blindness. Arch Neurol 51:474–481PubMed
5.
Zurück zum Zitat Bolognini N, Rasi F, Coccia M, Ladavas E (2005) Visual search improvement in hemianopic patients after audio–visual stimulation. Brain 128:2830–2842PubMedCrossRef Bolognini N, Rasi F, Coccia M, Ladavas E (2005) Visual search improvement in hemianopic patients after audio–visual stimulation. Brain 128:2830–2842PubMedCrossRef
6.
Zurück zum Zitat Poggel DA, Kasten E, Sabel BA (2004) Attentional cueing improves vision restoration therapy in patients with visual field defects. Neurology 63:2069–2076PubMed Poggel DA, Kasten E, Sabel BA (2004) Attentional cueing improves vision restoration therapy in patients with visual field defects. Neurology 63:2069–2076PubMed
7.
Zurück zum Zitat Nelles G, Esser J, Eckstein A, Tiede A, Gerhard H, Diener H (2001) Compensatory visual field training in recovery from hemianopia after stroke. Neurosci Lett 306:189–192PubMedCrossRef Nelles G, Esser J, Eckstein A, Tiede A, Gerhard H, Diener H (2001) Compensatory visual field training in recovery from hemianopia after stroke. Neurosci Lett 306:189–192PubMedCrossRef
8.
Zurück zum Zitat Pierrot-Deseilligny C, Rivaud S, Gaymard B, Muri R, Vermersch AI (1995) Cortical control of saccades. Ann Neurol 37:557–567PubMedCrossRef Pierrot-Deseilligny C, Rivaud S, Gaymard B, Muri R, Vermersch AI (1995) Cortical control of saccades. Ann Neurol 37:557–567PubMedCrossRef
9.
Zurück zum Zitat Bodis-Wollner I, Bucher SF, Seelos KC, Paulus W, Reiser M, Oertel WH (1997) Functional MRI mapping of occipital and frontal cortical activity during voluntary and imagined saccades. Neurology 49:416–420PubMed Bodis-Wollner I, Bucher SF, Seelos KC, Paulus W, Reiser M, Oertel WH (1997) Functional MRI mapping of occipital and frontal cortical activity during voluntary and imagined saccades. Neurology 49:416–420PubMed
10.
Zurück zum Zitat Nelles G, de Greiff A, Pscherer A, Stude P, Forsting M, Hufnagel A, Gerhard H, Esser J, Diener HC (2007) Saccade induced cortical activation in patients with post-stroke visual field defects. J Neurol 254:1244–1252PubMedCrossRef Nelles G, de Greiff A, Pscherer A, Stude P, Forsting M, Hufnagel A, Gerhard H, Esser J, Diener HC (2007) Saccade induced cortical activation in patients with post-stroke visual field defects. J Neurol 254:1244–1252PubMedCrossRef
11.
Zurück zum Zitat Kinsbourne M (1974) Lateral interactions in the brain. In: Kinsbourne M, Smith WL (eds) Hemispheric disconnection and cerebral function. C.C. Thomas, Springfield Kinsbourne M (1974) Lateral interactions in the brain. In: Kinsbourne M, Smith WL (eds) Hemispheric disconnection and cerebral function. C.C. Thomas, Springfield
12.
Zurück zum Zitat Albert ML (1973) A simple test of visual neglect. Neurology 23:658–664PubMed Albert ML (1973) A simple test of visual neglect. Neurology 23:658–664PubMed
13.
Zurück zum Zitat Heilmann KM, Watson RT, Valenstein E (1992) Neglect and related disorder. In: Heilmann KM, Valenstein E (eds) Clinical neuropsychology. Oxford University Press, New York Heilmann KM, Watson RT, Valenstein E (1992) Neglect and related disorder. In: Heilmann KM, Valenstein E (eds) Clinical neuropsychology. Oxford University Press, New York
14.
Zurück zum Zitat Frackowiak R, Friston K, Frith C, Dolan R, Mazziotta J (1997) Human brain function. Academic Press, San Diego Frackowiak R, Friston K, Frith C, Dolan R, Mazziotta J (1997) Human brain function. Academic Press, San Diego
15.
Zurück zum Zitat Friston KJ, Holmes AP, Price CJ, Buchel C, Worsley KJ (1999) Multisubject fMRI studies and conjunction analyses. Neuroimage 10:385–396PubMedCrossRef Friston KJ, Holmes AP, Price CJ, Buchel C, Worsley KJ (1999) Multisubject fMRI studies and conjunction analyses. Neuroimage 10:385–396PubMedCrossRef
16.
Zurück zum Zitat Talairach J, Tournoux P (1988) Coplanar stereotaxic atlas of the human brain. Thieme Verlag, New York Talairach J, Tournoux P (1988) Coplanar stereotaxic atlas of the human brain. Thieme Verlag, New York
17.
Zurück zum Zitat Anderson TJ, Jenkins IH, Brooks DJ, Hawken MB, Frackowiak RS, Kennard C (1994) Cortical control of saccades and fixation in man. A PET study. Brain 117:1073–1084PubMedCrossRef Anderson TJ, Jenkins IH, Brooks DJ, Hawken MB, Frackowiak RS, Kennard C (1994) Cortical control of saccades and fixation in man. A PET study. Brain 117:1073–1084PubMedCrossRef
18.
Zurück zum Zitat Luna B, Thulborn KR, Strojwas MH, McCurtain BJ, Berman RA, Genovese CR, Sweeney JA (1998) Dorsal cortical regions subserving visually guided saccades in humans: an fMRI study. Cereb Cortex 8:40–47PubMedCrossRef Luna B, Thulborn KR, Strojwas MH, McCurtain BJ, Berman RA, Genovese CR, Sweeney JA (1998) Dorsal cortical regions subserving visually guided saccades in humans: an fMRI study. Cereb Cortex 8:40–47PubMedCrossRef
19.
Zurück zum Zitat Bittar RG, Ptito M, Faubert J, Dumoulin SO, Ptito A (1999) Activation of the remaining hemisphere following stimulation of the blind hemifield in hemispherectomized subjects. Neuroimage 10:339–346PubMedCrossRef Bittar RG, Ptito M, Faubert J, Dumoulin SO, Ptito A (1999) Activation of the remaining hemisphere following stimulation of the blind hemifield in hemispherectomized subjects. Neuroimage 10:339–346PubMedCrossRef
20.
Zurück zum Zitat Nelles G, Widman G, de Greiff A, Meistrowitz A, Dimitrova A, Weber J, Forsting M, Esser J, Diener HC (2002) Brain representation of hemifield stimulation in poststroke visual field defects. Stroke 33:1286–1293PubMedCrossRef Nelles G, Widman G, de Greiff A, Meistrowitz A, Dimitrova A, Weber J, Forsting M, Esser J, Diener HC (2002) Brain representation of hemifield stimulation in poststroke visual field defects. Stroke 33:1286–1293PubMedCrossRef
21.
Zurück zum Zitat Henriksson L, Raninen A, Näsänen R, Hyvärinen L, Vanni S (2007) Training-induced cortical representation of a hemianopic hemifield. J Neurol Neurosurg Psychiatry 78:74–81PubMedCrossRef Henriksson L, Raninen A, Näsänen R, Hyvärinen L, Vanni S (2007) Training-induced cortical representation of a hemianopic hemifield. J Neurol Neurosurg Psychiatry 78:74–81PubMedCrossRef
22.
Zurück zum Zitat Darian-Smith C, Gilbert CD (1994) Axonal sprouting accompanies functional reorganization in adult cat striate cortex. Nature 368:737–740PubMedCrossRef Darian-Smith C, Gilbert CD (1994) Axonal sprouting accompanies functional reorganization in adult cat striate cortex. Nature 368:737–740PubMedCrossRef
23.
Zurück zum Zitat Tardif E, Clarke S (2002) Commissural connections of human superior colliculus. Neuroscience 111:363–372PubMedCrossRef Tardif E, Clarke S (2002) Commissural connections of human superior colliculus. Neuroscience 111:363–372PubMedCrossRef
24.
Zurück zum Zitat Schoenfeld MA, Heinze HJ, Woldorff MG (2002) Unmasking motion-processing activity in human brain area V5/MT + mediated by pathways that bypass primary visual cortex. Neuroimage 17:769–779PubMedCrossRef Schoenfeld MA, Heinze HJ, Woldorff MG (2002) Unmasking motion-processing activity in human brain area V5/MT + mediated by pathways that bypass primary visual cortex. Neuroimage 17:769–779PubMedCrossRef
25.
Zurück zum Zitat Ffytche DH, Skidmore BD, Zeki S (1995) Motion-from-hue activates area V5 of human visual cortex. Proc Biol Sci 260:353–358PubMedCrossRef Ffytche DH, Skidmore BD, Zeki S (1995) Motion-from-hue activates area V5 of human visual cortex. Proc Biol Sci 260:353–358PubMedCrossRef
26.
Zurück zum Zitat Liu Y, Rouiller EM (1999) Mechanisms of recovery of dexterity following unilateral lesion of the sensorimotor cortex in adult monkeys. Exp Brain Res 128:149–159PubMedCrossRef Liu Y, Rouiller EM (1999) Mechanisms of recovery of dexterity following unilateral lesion of the sensorimotor cortex in adult monkeys. Exp Brain Res 128:149–159PubMedCrossRef
27.
Zurück zum Zitat Kimmig H, Greenlee MW, Gondan M, Schira M, Kassubek J, Mergner T (2001) Relationship between saccadic eye movements and cortical activity as measured by fMRI: quantitative and qualitative aspects. Exp Brain Res 141:184–194PubMedCrossRef Kimmig H, Greenlee MW, Gondan M, Schira M, Kassubek J, Mergner T (2001) Relationship between saccadic eye movements and cortical activity as measured by fMRI: quantitative and qualitative aspects. Exp Brain Res 141:184–194PubMedCrossRef
28.
Zurück zum Zitat Sommer MA, Tehovnik EJ (1997) Reversible inactivation of macaque frontal eye field. Exp Brain Res 116:229–249PubMedCrossRef Sommer MA, Tehovnik EJ (1997) Reversible inactivation of macaque frontal eye field. Exp Brain Res 116:229–249PubMedCrossRef
29.
Zurück zum Zitat Schiller PH, True SD, Conway JL (1980) Deficits in eye movements following frontal eye field and superior colliculus ablations. J Neurophysiol 44:1175–1189PubMed Schiller PH, True SD, Conway JL (1980) Deficits in eye movements following frontal eye field and superior colliculus ablations. J Neurophysiol 44:1175–1189PubMed
30.
Zurück zum Zitat Marshall RS, Ferrera JJ, Barnes A, Xian Z, O’Brien KA, Chmayssani M, Hirsch J, Lazar RM (2008) Brain activity associated with stimulation therapy of the visual borderzone in hemianopic stroke patients. Neurorehabil Neural Repair 22:136–144PubMed Marshall RS, Ferrera JJ, Barnes A, Xian Z, O’Brien KA, Chmayssani M, Hirsch J, Lazar RM (2008) Brain activity associated with stimulation therapy of the visual borderzone in hemianopic stroke patients. Neurorehabil Neural Repair 22:136–144PubMed
Metadaten
Titel
Eye-movement training-induced plasticity in patients with post-stroke hemianopia
verfasst von
Gereon Nelles
Anja Pscherer
Armin de Greiff
Michael Forsting
Horst Gerhard
Joachim Esser
H. Christoph Diener
Publikationsdatum
01.05.2009
Verlag
D. Steinkopff-Verlag
Erschienen in
Journal of Neurology / Ausgabe 5/2009
Print ISSN: 0340-5354
Elektronische ISSN: 1432-1459
DOI
https://doi.org/10.1007/s00415-009-5005-x

Weitere Artikel der Ausgabe 5/2009

Journal of Neurology 5/2009 Zur Ausgabe

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Neu im Fachgebiet Neurologie

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.