Factors Affecting Diagnostic Yield of Lesional Bone Biopsy in Hematologic Malignancy Patients
- 01.11.2023
- CLINICAL INVESTIGATION
Erschienen in:
- Verfasst von
- Timothy M. Cooke
- Majid Maybody
- Ahmed K. Aly
- Elena N. Petre
- Ernesto Santos
- Ariela Noy
- Alexander Y. Chan
- Eric Lis
- Natalie Gangai
- Francois H. Cornelis
- Amgad M. Moussa
- Erschienen in
- CardioVascular and Interventional Radiology | Ausgabe 1/2024
Abstract
Purpose
To evaluate factors affecting the diagnostic yield (percent of biopsy samples leading to a pathologic diagnosis) of lesional bone biopsies in patients with hematologic malignancies.
Materials and Methods
This retrospective study included 206 lesional bone biopsies in 182 patients with a hematologic malignancy between January 2017 and December 2022. The parameters that were reviewed to evaluate diagnostic yield included biopsy device type (manual vs. electric-powered drill), number of biopsy cores acquired, core biopsy needle gauge, preliminary intra-procedural sample adequacy (touch preparation cytology determining if samples are adequate for final pathologic examination), lesion morphology on Computed Tomography (CT), and presence of crush artifact.
Results
Review of 206 lesional biopsies showed overall diagnostic yield to be 89.8% (185/206). The two statistically significant factors affecting diagnostic yield were biopsy device type and in-room adequacy. 41/42 samples obtained with the electric-powered drill and 144/164 samples obtained using a variety of manual needles were diagnostic (97.6% vs 87.8%, p = 0.03). Of the 192 samples that were assessed for sample adequacy intra-procedurally, 97/102 of the samples that were deemed adequate were diagnostic, and 77/90 of the samples where intra-procedural adequacy was not confirmed were diagnostic (95.1% vs 85.6%, p = 0.018). The remaining factors did not affect diagnostic yield.
Conclusion
The use of an electric-powered drill bone biopsy device and intra-procedural confirmation of sample adequacy are associated with a higher diagnostic yield of lesional bone biopsies in patients with hematologic malignancies. The presence or absence of crush artifact did not significantly affect the diagnostic yield in these patients.
Level of Evidence IV.
Graphical Abstract
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- Titel
- Factors Affecting Diagnostic Yield of Lesional Bone Biopsy in Hematologic Malignancy Patients
- Verfasst von
-
Timothy M. Cooke
Majid Maybody
Ahmed K. Aly
Elena N. Petre
Ernesto Santos
Ariela Noy
Alexander Y. Chan
Eric Lis
Natalie Gangai
Francois H. Cornelis
Amgad M. Moussa
- Publikationsdatum
- 01.11.2023
- Verlag
- Springer US
- Erschienen in
-
CardioVascular and Interventional Radiology / Ausgabe 1/2024
Print ISSN: 0174-1551
Elektronische ISSN: 1432-086X - DOI
- https://doi.org/10.1007/s00270-023-03594-9
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