Background
Methods
Patient inclusions
Data recorded
Statistical analysis
Results
Study population
Variablesa | Patients N = 123 |
---|---|
BMIb, c | 24.9 ± 4.1 |
Malnourished (BMI < 21 kg/m2)c | 18 (15.4) |
Charlson comorbidity indexb, d | 1.35 ± 1.11 |
Number of medications per dayb, e | 4.2 ± 2.6 |
Polypharmacy (> 3 medications per day) e | 61 (51.3) |
Psychotropic drugsd | 69 (57.5) |
Symptomatic treatment of AD f | 106 (87.6) |
Depression c | 20 (19.6) |
ADLs b, g | 5.1 ± 1.2 |
Washing g | 77 (63.1) |
Dressing g | 83 (68.0) |
Toileting g | 106 (86.9) |
Transferring g | 100 (82.0) |
Continence g | 79 (64.7) |
Feeding g | 110 (90.2) |
IADL (not sex dependent) b, e | 1.8 ± 1.2 |
Ability to use telephone g | 105 (86.1) |
Ability to do shopping e | 25 (20.8) |
Ability to use transport g | 61 (50) |
Ability to manage own treatment f | 29 (24.0) |
Caregiver’s age b, d | 66.3 ± 14.3 |
Caregiver’s sex | |
Male | 36 (29.3) |
Female | 87 (70.7) |
Relationship to caregiver: spouse / child | 94 (76.4) |
Home nurse h | 18 (17.1) |
Home help for housework i | 57 (53.8) |
Home delivery of meals i | 9 (8.5) |
Attending daycare center j | 21 (20.2) |
NPI score b, d | 13.0 ± 11.7 |
Delusions g | 24 (19.7) |
Hallucinations d | 8 (6.7) |
Agitation/aggression g | 54 (44.3) |
Dysphoria/depression k | 6 (5.6) |
Anxiety g | 76 (62.3) |
Eurphoria g | 34 (27.9) |
Apathy g | 65 (53.3) |
Disinhibition g | 25 (20.5) |
Aberrant motor behaviour e | 9 (7.5) |
Irritability g | 62 (50.8) |
Sleep & nighttime behaviour change g | 39 (32.0) |
Appetite & eating change g | 33 (27.0) |
Caregiver burden l | 62 (60.8) |
QoL-AD patient score
Variables | Patient score (n = 99) | Caregiver score (n = 84) | Overall score (n = 100) | ||||||
---|---|---|---|---|---|---|---|---|---|
QoL-AD scorea | Multivariate analyseb | QoL-AD scorea | Multivariate analysec | QoL-AD scorea | Multivariate analysed | ||||
β ± SE (β) | p | β ± SE (β) | p | β ± SE (β) | p | ||||
Depression | ** | *** | *** | ||||||
yes | 33.3 ± 4.6 | −2.56 ± 1.28 | 29.8 ± 3.8 | −3.46 ± 1.09 | 32.1 ± 3.6 | −3.26 ± 1.02 | |||
no | 37.1 ± 5.0 | 33.7 ± 4.5 | 36.0 ± 4.1 | ||||||
Polypharmacy | * | ** | ** | ||||||
yes | 35.0 ± 4.7 | −1.80 ± 0.99 | 31.6 ± 4.5 | −1.91 ± 0.92 | 33.9 ± 4.0 | −1.85 ± 0.81 | |||
no | 37.0 ± 5.2 | 33.7 ± 5.1 | 35.9 ± 4.4 | ||||||
Anxiety (NPI) | * | ||||||||
yes | 35.4 ± 5.0 | −1.70 ± 1.01 | |||||||
no | 37.3 ± 4.9 | ||||||||
Carer burden | *** | ||||||||
yes | 31.0 ± 4.8 | −3.50 ± 0.91 | |||||||
no | 35.3 ± 4.1 |
Patient | Caregiver | |||||
---|---|---|---|---|---|---|
Depression | Polypharmacy | Anxiety (NPI) | Depression | Polypharmacy | Caregiver burden | |
Physical health | * | * | * | |||
Energy | * | * | ||||
Mood | * | * | * | * | * | |
Living situation | ||||||
Memory | * | * | * | |||
Family | * | |||||
Marriage | * | |||||
Friends | * | |||||
Self as a whole | * | * | ||||
Ability to do chores | * | |||||
Ability to do things for fun | * | * | * | * | ||
Financial situation | ||||||
Life as a whole | * | * | * |