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Erschienen in: International Ophthalmology 5/2020

13.01.2020 | Original Paper

Factors influencing the reduction in corneal endothelial cells after Ex-Press® surgery

verfasst von: Naoki Tojo, Ayaka Numata, Atsushi Hayashi

Erschienen in: International Ophthalmology | Ausgabe 5/2020

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Abstract

Purpose

We investigated the factors that influence the reduction in corneal endothelial cells after Ex-Press® surgery.

Methods

This was a retrospective study. We included patients who had undergone Ex-Press surgery and were followed up for > 2. We analyzed the corneal endothelial cell density (ECD) before and after Ex-Press surgery. We investigated the insertion position (Ex-Press device was inserted into cornea or trabecular meshwork (TM)), Ex-Press–iris touch, cornea–iris touch, peripheral anterior synechiae, history of trabeculotomy, history of selective laser trabeculoplasty, type of glaucoma, and simultaneous cataract surgery as influencing factors. We used multivariate analysis to determine the factors influencing the reduction rate of ECD.

Results

We included 129 eyes. The mean of ECD had decreased 7.0% at 2 years. Ex-Press surgeries significantly decreased the ECD after 2 years (p = 0.0118). As a result of the multivariate analysis, the factor that led to a significantly faster reduction in ECD was the insertion position of the Ex-Press (p < 0.0001). The reduction rate of ECD after 2 years in cases of insertion into the cornea (27 eyes) was 15.1 ± 3.6%, and in cases of insertion into a TM (102 eyes), it was 5.2 ± 1.4%.

Conclusions

Insertion into the cornea was a risk factor for rapid ECD loss. The Ex-Press should be inserted into a TM for long-term protection of the corneal endothelial cells.
Literatur
4.
Zurück zum Zitat Arimura S, Takihara Y, Miyake S, Iwasaki K, Gozawa M, Matsumura T, Tomomatsu T, Takamura Y, Inatani M (2016) Randomized clinical trial for early postoperative complications of Ex-PRESS implantation versus trabeculectomy: complications postoperatively of Ex-PRESS versus trabeculectomy study (CPETS). Sci Rep 6:26080. https://doi.org/10.1038/srep26080 CrossRefPubMedPubMedCentral Arimura S, Takihara Y, Miyake S, Iwasaki K, Gozawa M, Matsumura T, Tomomatsu T, Takamura Y, Inatani M (2016) Randomized clinical trial for early postoperative complications of Ex-PRESS implantation versus trabeculectomy: complications postoperatively of Ex-PRESS versus trabeculectomy study (CPETS). Sci Rep 6:26080. https://​doi.​org/​10.​1038/​srep26080 CrossRefPubMedPubMedCentral
15.
Zurück zum Zitat Soro-Martinez MI, Villegas-Perez MP, Sobrado-Calvo P, Ruiz-Gomez JM, de Imperial Miralles, Mora-Figueroa J (2010) Corneal endothelial cell loss after trabeculectomy or after phacoemulsification, IOL implantation and trabeculectomy in 1 or 2 steps. Graefe’s Arch Clin Exp Ophthalmol 248:249–256. https://doi.org/10.1007/s00417-009-1185-4 CrossRef Soro-Martinez MI, Villegas-Perez MP, Sobrado-Calvo P, Ruiz-Gomez JM, de Imperial Miralles, Mora-Figueroa J (2010) Corneal endothelial cell loss after trabeculectomy or after phacoemulsification, IOL implantation and trabeculectomy in 1 or 2 steps. Graefe’s Arch Clin Exp Ophthalmol 248:249–256. https://​doi.​org/​10.​1007/​s00417-009-1185-4 CrossRef
16.
Zurück zum Zitat Gagnon MM, Boisjoly HM, Brunette I, Charest M, Amyot M (1997) Corneal endothelial cell density in glaucoma. Cornea 16:314–318CrossRef Gagnon MM, Boisjoly HM, Brunette I, Charest M, Amyot M (1997) Corneal endothelial cell density in glaucoma. Cornea 16:314–318CrossRef
17.
Zurück zum Zitat Smith DL, Skuta GL, Lindenmuth KA, Musch DC, Bergstrom TJ (1991) The effect of glaucoma filtering surgery on corneal endothelial cell density. Ophthalmic Surg 22:251–255PubMed Smith DL, Skuta GL, Lindenmuth KA, Musch DC, Bergstrom TJ (1991) The effect of glaucoma filtering surgery on corneal endothelial cell density. Ophthalmic Surg 22:251–255PubMed
18.
Zurück zum Zitat Ayaki M, Noda Y, Yaguchi S, Koide R, Iwasawa A, Inoue T, Inoue Y (2009) Cytotoxicity of antiglaucoma ophthalmic solutions for human corneal endothelial cells. Nippon Ganka Gakkai zasshi 113:576–582PubMed Ayaki M, Noda Y, Yaguchi S, Koide R, Iwasawa A, Inoue T, Inoue Y (2009) Cytotoxicity of antiglaucoma ophthalmic solutions for human corneal endothelial cells. Nippon Ganka Gakkai zasshi 113:576–582PubMed
20.
Zurück zum Zitat Sihota R, Sharma T, Agarwal HC (1998) Intraoperative mitomycin C and the corneal endothelium. Acta Ophthalmol Scand 76:80–82CrossRef Sihota R, Sharma T, Agarwal HC (1998) Intraoperative mitomycin C and the corneal endothelium. Acta Ophthalmol Scand 76:80–82CrossRef
22.
Zurück zum Zitat Macdonald JM, Geroski DH, Edelhauser HF (1987) Effect of inflammation on the corneal endothelial pump and barrier. Curr Eye Res 6:1125–1132CrossRef Macdonald JM, Geroski DH, Edelhauser HF (1987) Effect of inflammation on the corneal endothelial pump and barrier. Curr Eye Res 6:1125–1132CrossRef
26.
Zurück zum Zitat Wu KY, Wang HZ, Hong SJ (2008) Mechanism of mitomycin-induced apoptosis in cultured corneal endothelial cells. Mol Vis 14:1705–1712PubMedPubMedCentral Wu KY, Wang HZ, Hong SJ (2008) Mechanism of mitomycin-induced apoptosis in cultured corneal endothelial cells. Mol Vis 14:1705–1712PubMedPubMedCentral
Metadaten
Titel
Factors influencing the reduction in corneal endothelial cells after Ex-Press® surgery
verfasst von
Naoki Tojo
Ayaka Numata
Atsushi Hayashi
Publikationsdatum
13.01.2020
Verlag
Springer Netherlands
Erschienen in
International Ophthalmology / Ausgabe 5/2020
Print ISSN: 0165-5701
Elektronische ISSN: 1573-2630
DOI
https://doi.org/10.1007/s10792-020-01286-8

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