The online version of this article (https://doi.org/10.1007/s12350-018-1387-4) contains supplementary material, which is available to authorized users.
The authors of this article have provided a PowerPoint file, available for download at SpringerLink, which summarises the contents of the paper and is free for re-use at meetings and presentations. Search for the article DOI on SpringerLink.com.
Boqia Xie and Bi-Xi Chen have contributed equally to this work and are co-first authors.
This retrospective study was designed to explore the factors relevant to increased atrial 18F-fluorodeoxyglucose (FDG) uptake in patients with atrial fibrillation (AF) who had undergone routine whole-body positron emission tomography/computed tomography (PET/CT) imaging.
Forty-eight consecutive AF patients (32 persistent, 16 paroxysmal) were identified from our routine FDG PET/CT database. Twenty-two control subjects were selected to establish the normal range of FDG uptake (maximum standardized uptake value, SUVmax) in target tissues. A target-to-background ratio (TBR) was calculated to determine abnormal uptake in the atrium and atrial appendage (AA). Univariate comparisons and multivariate regression analyses were conducted to explore the factors associated with the increased FDG accumulation in the atrium and AA. Seventeen AF patients, all with persistent AF, had increased atrial FDG uptake. Most of them (14, or 82.4%) had increased uptake in the right atrium. Eleven AF patients, 9 with persistent AF, had increased uptake in the AA, and bilateral AAs were equally involved. Multivariate logistic regression analyses identified that female gender, persistent AF, and activity in epicardial adipose tissue (EAT) were independent factors predicting the increased activity of the atrium; also, SUVmax of the left ventricle was found for the AA. In addition, multivariate linear regression analyses showed that EAT activity was the only independent variable linearly correlated with the activity of the atrium and AA.
Atrial uptake was present in persistent AF and localized mainly in the right atrium, whereas bilateral AAs could be equally involved. Multiple factors contributed to the increased activity in atrium; in particular, the EAT activity was independently correlated with the activity of the atrium and AA.
Okura K, Maeno K, Hirazawa M, Takemori H, Toya D, Tanaka N, et al. Fluorodeoxyglucose accumulation in the left atrial appendage of a patient with paroxysmal atrial fibrillation. J Cardiol Cases 2012;5:e32–5. CrossRef
Dong A, Zhao T, Gong J, Zuo C. Diffuse FDG uptake of the bilateral atrial walls in a patient with atrial fibrillation. Clin Nucl Med 2014;39:167–9. PubMed
Firth D. Bias reduction of maximum likelihood estimates. Biometrika 1993;80:27-38. CrossRef
Team RDC. R: A language and environment for statistical computing. R foundation for statistical computing, Vienna, Austria. Computing 2016;14:12-21.
Modrego J, Maroto L, Tamargo J, Azcona L, Mateos-Cáceres P, Segura A, et al. Comparative expression of proteins in left and right atrial appendages from patients with mitral valve disease at sinus rhythm and atrial fibrillation. J Cardiovasc Electrophysiol 2010;21:859-68. PubMed
Manabe O, Yoshinaga K, Ohira H, Masuda A, Sato T, Tsujino I, et al. The effects of 18-h fasting with low-carbohydrate diet preparation on suppressed physiological myocardial (18)F-fluorodeoxyglucose (FDG) uptake and possible minimal effects of unfractionated heparin use in patients with suspected cardiac involvement sarcoidosis. J Nucl Cardiol 2016;23:244-52. CrossRefPubMed
- Factors relevant to atrial 18F-fluorodeoxyglucose uptake in atrial fibrillation
MD Boqia Xie
MD Bi-Xi Chen
MD Jiao-Yan Wu
MD Xingpeng Liu
MD Min-Fu Yang
- Springer US
Journal of Nuclear Cardiology
Print ISSN: 1071-3581
Elektronische ISSN: 1532-6551
Neu im Fachgebiet Kardiologie
e.Med Kampagnen-Visual, Mail Icon II