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Nuclear Medicine and Molecular Imaging

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19.10.2015 | Interesting Image

False-Positive Radioactive Iodine Uptake Mimicking Miliary Lung Metastases in a Patient Affected by Papillary Thyroid Cancer and IgA Deficiency

verfasst von: Andrew Paul Demidowich, Amartya Kundu, James C. Reynolds, Francesco S. Celi

Erschienen in: Nuclear Medicine and Molecular Imaging | Ausgabe 3/2016

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Abstract

A 42-year-old female with immunoglobulin A deficiency and recurrent sinopulmonary infections underwent thyroidectomy for papillary thyroid cancer (PTC). Follow-up ¹²³I scintigraphy demonstrated diffuse pulmonary uptake, suggesting metastatic disease. However, subsequent pathologic, biochemical and radiographic testing proved that she was in fact disease free, and the initial ¹²³I pulmonary uptake was identified as a false positive. Inflammatory conditions may rarely cause iodine uptake in non-thyroidal tissues due to local retention, organification, and/or immunologic utilization. To avoid exposing patients to unnecessary treatments, it is critical for clinicians to recognize that comorbid pulmonary conditions may mimic metastatic PTC on radioiodine scintigraphy.

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Titel: False-Positive Radioactive Iodine Uptake Mimicking Miliary Lung Metastases in a Patient Affected by Papillary Thyroid Cancer and IgA Deficiency
verfasst von: Andrew Paul Demidowich
Amartya Kundu
James C. Reynolds
Francesco S. Celi
Publikationsdatum: 19.10.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: Nuclear Medicine and Molecular Imaging / Ausgabe 3/2016
Print ISSN: 1869-3474
Elektronische ISSN: 1869-3482
DOI: https://doi.org/10.1007/s13139-015-0375-8

Springer Medizin

Abstract

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