Skip to main content
Erschienen in: Discover Oncology 1/2019

08.09.2018 | Original Paper

Familial Cancer Clustering in Patients with Prolactinoma

verfasst von: Sandra Pekic, Ivan Soldatovic, Dragana Miljic, Marko Stojanovic, Mirjana Doknic, Milan Petakov, Vera Popovic

Erschienen in: Discover Oncology | Ausgabe 1/2019

Einloggen, um Zugang zu erhalten

Abstract

People are at higher risk for malignancy as they get older or have a strong family history of cancer. This study aims to collect family history of cancer in a large cohort of patients with pituitary adenomas (PA) in outpatient clinic from years 2005–2017. Overall, 46.6% of 1062 patients with PA had a family member affected with cancer. Breast cancer in family members was reported in 15.3% of patients with prolactinomas which was significantly higher than in families of patients with non-functioning pituitary adenomas (NFPA) (10.0%) or acromegaly (6.8%) (p = 0.004). Lung cancer in family members was reported in 12.1% of patients with prolactinomas, significantly higher than in families of NFPA patients (7.0%, p = 0.049). Colorectal cancer in relatives of patients with PA was reported with any type of PA. Furthermore, patients with a positive family history of malignancy were diagnosed with PA at an earlier age than patients with a negative family history (43.6 ± 15.9 vs 46.0 ± 16.4 years, p = 0.015). Female patients with prolactinoma are more commonly diagnosed before the age of 25 years. Forty-two percent of patients with PA diagnosed before the age of 25 years had a second- and third-degree relative with cancer, significantly higher than patients with PA diagnosed later in life (25.8%, p < 0.001). Breast, lung, and colon cancers in second- and third-degree relatives were reported in significantly higher proportion of patients with PA diagnosed before the age of 25 years, compared with patients with PA diagnosed later in life (breast cancer: 10.9 vs 6.1%, p = 0.033; lung cancer: 10.9 vs 5.8%, p = 0.02; colon cancer: 9.5 vs 4.0%, p = 0.004). These results suggest familial cancer clustering in patients with prolactinoma and young patients with PA (younger than 25 years at diagnosis of PA). In particular, there is a strong association between prolactinoma and family history of breast and lung cancers. Further research of possible shared genetic susceptibility of prolactinoma and breast and lung cancers is needed.
Literatur
1.
Zurück zum Zitat Osamura RY, Lopes MBS, Grossman A, Kontogeorgos G, Trouillas J (2017) Introduction. In: Lloyd RV, Osamura RY, Kloppel G, Rosai J (eds) WHO classification of tumours of endocrine organs, 4th edn. IARC Press, Lyon Osamura RY, Lopes MBS, Grossman A, Kontogeorgos G, Trouillas J (2017) Introduction. In: Lloyd RV, Osamura RY, Kloppel G, Rosai J (eds) WHO classification of tumours of endocrine organs, 4th edn. IARC Press, Lyon
2.
Zurück zum Zitat Marques P, Korbonits M (2017) Genetic aspects of pituitary adenomas. Endocrinol Metab Clin N Am 46:335–374CrossRef Marques P, Korbonits M (2017) Genetic aspects of pituitary adenomas. Endocrinol Metab Clin N Am 46:335–374CrossRef
3.
Zurück zum Zitat Frank C, Fallah M, Sundquist J, Hemminki A, Hemminki K (2015) Population landscape of familial cancer. Sci Rep 5:12891CrossRef Frank C, Fallah M, Sundquist J, Hemminki A, Hemminki K (2015) Population landscape of familial cancer. Sci Rep 5:12891CrossRef
4.
Zurück zum Zitat Hemminki K, Forsti A, Ji J (2007) Incidence and familial risks in pituitary adenoma and associated tumors. Endocr Relat Cancer 14:103–109CrossRef Hemminki K, Forsti A, Ji J (2007) Incidence and familial risks in pituitary adenoma and associated tumors. Endocr Relat Cancer 14:103–109CrossRef
5.
Zurück zum Zitat Couldwell WT, Cannon-Albright LS (2014) Co-prevalence of other tumors in patients harboring pituitary tumors. J Neurosurg 121:1474–1477CrossRef Couldwell WT, Cannon-Albright LS (2014) Co-prevalence of other tumors in patients harboring pituitary tumors. J Neurosurg 121:1474–1477CrossRef
6.
Zurück zum Zitat Murff HJ, Spigel DR, Syngal S (2004) Does this patient have a family history of cancer? An evidence-based analysis of the accuracy of family cancer history. JAMA 292:1480–1489CrossRef Murff HJ, Spigel DR, Syngal S (2004) Does this patient have a family history of cancer? An evidence-based analysis of the accuracy of family cancer history. JAMA 292:1480–1489CrossRef
Metadaten
Titel
Familial Cancer Clustering in Patients with Prolactinoma
verfasst von
Sandra Pekic
Ivan Soldatovic
Dragana Miljic
Marko Stojanovic
Mirjana Doknic
Milan Petakov
Vera Popovic
Publikationsdatum
08.09.2018
Verlag
Springer US
Erschienen in
Discover Oncology / Ausgabe 1/2019
Print ISSN: 1868-8497
Elektronische ISSN: 2730-6011
DOI
https://doi.org/10.1007/s12672-018-0348-3

Weitere Artikel der Ausgabe 1/2019

Discover Oncology 1/2019 Zur Ausgabe

Update Onkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.