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07.08.2019 | Cohort Studies

Familial Mediterranean fever is associated with a wide spectrum of inflammatory disorders: results from a large cohort study

verfasst von: Nuh Atas, Berkan Armagan, Erdal Bodakci, Hasan Satis, Alper Sari, Nazife Sule Yasar Bilge, Reyhan Bilici Salman, Gozde Kubra Yardımcı, Hakan Babaoglu, Aslihan Avanoglu Guler, Hazan Karadeniz, Levent Kilic, Mehmet Akif Ozturk, Berna Goker, Seminur Haznedaroglu, Umut Kalyoncu, Timucin Kasifoglu, Abdurrahman Tufan

Erschienen in: Rheumatology International | Ausgabe 1/2020

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Abstract

Familial Mediterranean fever (FMF) is characterized by recurrent short-lived/self-limiting inflammatory attacks. Besides these, a substantial number of patients with FMF present with a variety of other inflammatory diseases; however, this issue has not been systematically studied previously. Hence, we aimed to investigate the frequency of inflammatory comorbid diseases in a large FMF cohort. All patients were recruited from “FMF in Central Anatolia (FiCA) Cohort”, comprising 971 (mean age 35.3 ± 12 years, 61.5% female) adult subjects. All patients fulfilled Tel Hashomer criteria. Demographic data, FMF disease characteristics, MEFV gene mutations, and comorbid inflammatory diseases were meticulously questioned, and laboratory features and genotype data were retrieved from hospital records. There were comorbid inflammatory diseases in 205 (21.1%) patients. The most common inflammatory disease was spondyloarthritis (12.9%). Other remarkable inflammatory disorders were psoriasis, immunoglobulin A vasculitis/Henoch–Schönlein purpura, Behçet’s disease and inflammatory bowel diseases. Cryptogenic organizing pneumonia is a newly defined entity in our cohort which is seemed to be associated with FMF (0.3%). Number of patients with persistent inflammation was higher in those with comorbid diseases (p < 0.001). Our results suggest that FMF is commonly associated with other inflammatory diseases. Therefore, clinicians should be cautious about comorbid inflammatory diseases in FMF patients, particularly in those with persistent inflammation. Identification of pathogenic pathways linking FMF to these diseases warrants further investigations.

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Titel: Familial Mediterranean fever is associated with a wide spectrum of inflammatory disorders: results from a large cohort study
verfasst von: Nuh Atas
Berkan Armagan
Erdal Bodakci
Hasan Satis
Alper Sari
Nazife Sule Yasar Bilge
Reyhan Bilici Salman
Gozde Kubra Yardımcı
Hakan Babaoglu
Aslihan Avanoglu Guler
Hazan Karadeniz
Levent Kilic
Mehmet Akif Ozturk
Berna Goker
Seminur Haznedaroglu
Umut Kalyoncu
Timucin Kasifoglu
Abdurrahman Tufan
Publikationsdatum: 07.08.2019
Verlag: Springer Berlin Heidelberg
Erschienen in: Rheumatology International / Ausgabe 1/2020
Print ISSN: 0172-8172
Elektronische ISSN: 1437-160X
DOI: https://doi.org/10.1007/s00296-019-04412-7

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Familial Mediterranean fever is associated with a wide spectrum of inflammatory disorders: results from a large cohort study

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