Background
Methods
Results
SL | UL | CL | ||||
---|---|---|---|---|---|---|
Offspring | Parents | Offspring | Parents | Offspring | Parents | |
Total population | 8,850,394 | 8,090,648 | 8,850,394 | 8,090,648 | 8,850,394 | 8,090,648 |
Diagnosis of events | ||||||
No. of events | 7906 | 8241 | 170,757 | 219,354 | 204,369 | 309,561 |
Mean age at diagnosis | 43.8 ± 16.9 | 51.7 ± 16.8 | 47.8 ± 15.5 | 54.9 ± 16.8 | 47.1 ± 14.7 | 57.3 ± 18.2 |
Median age | 45 | 52 | 49 | 55 | 47 | 58 |
Incidence rate per 100,000 person yearsa | 4.1 | 3.6 | 94.2 | 90.5 | 111.4 | 120.8 |
Men | Women | All | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Family history | O | SIR | 95% CI | O | SIR | 95% CI | O | SIR | 95% CI | |||
SL | 31 |
1.95
|
1.32
|
2.77
| 39 |
2.15
|
1.53
|
2.94
| 70 |
2.06
|
1.60
|
2.60
|
UL | 19,234 |
1.91
|
1.88
|
1.94
| 11,221 |
1.99
|
1.95
|
2.02
| 30,455 |
1.94
|
1.92
|
1.96
|
CL | 15,534 |
1.82
|
1.79
|
1.85
| 33,423 |
1.81
|
1.79
|
1.83
| 48,957 |
1.82
|
1.80
|
1.83
|
Risk in offspring | Family history | Men | Women | All | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
O | SIR | 95% CI | O | SIR | 95% CI | O | SIR | 95% CI | |||||
SL | UL | 398 | 1.04 | 0.94 | 1.15 | 436 | 1.03 | 0.94 | 1.13 | 834 | 1.04 | 0.97 | 1.11 |
SL | CL | 572 | 1.06 | 0.97 | 1.15 | 678 |
1.14
|
1.05
|
1.23
| 1250 |
1.10
|
1.04
|
1.16
|
UL | SL | 494 | 1.09 | 0.99 | 1.19 | 340 |
1.27
|
1.13
|
1.41
| 834 |
1.15
|
1.08
|
1.21
|
UL | CL | 5410 |
1.17
|
1.14
|
1.21
| 3316 |
1.16
|
1.12
|
1.20
| 8726 |
1.17
|
1.14
|
1.19
|
CL | SL | 267 | 1.03 | 0.91 | 1.16 | 714 |
1.18
|
1.09
|
1.27
| 981 |
1.14
|
1.07
|
1.21
|
CL | UL | 7379 |
1.17
|
1.14
|
1.20
| 16,445 |
1.17
|
1.15
|
1.19
| 23,824 |
1.17
|
1.16
|
1.19
|
Family history of stone diseases | O | SIR | 95% CI | ||
---|---|---|---|---|---|
SL | Only SL | 63 |
2.04
|
1.57
|
2.61
|
SL with others (UL or CL) | 7 | 2.27 | 0.90 | 4.71 | |
UL | Only UL | 28,367 |
1.94
|
1.92
|
1.97
|
UL with others (SL or CL) | 2088 |
1.72
|
1.65
|
1.80
| |
CL | Only CL | 46,157 |
1.82
|
1.81
|
1.84
|
CL with others (UL or SL) | 2800 |
1.59
|
1.53
|
1.65
|
Risk in spouse | Spouse history | Husbands | Wives | All | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
O | SIR | 95% CI | O | SIR | 95% CI | O | SIR | 95% CI | |||||
SL | UL | 100 |
1.26
|
1.03
|
1.53
| 200 | 1.01 | 0.88 | 1.16 | 300 | 1.08 | 0.96 | 1.21 |
SL | CL | 37 | 0.82 | 0.58 | 1.13 | 69 | 1.20 | 0.93 | 1.51 | 106 | 1.03 | 0.84 | 1.25 |
UL | SL | 200 | 1.00 | 0.86 | 1.15 | 100 |
1.26
|
1.02
|
1.53
| 300 | 1.07 | 0.95 | 1.20 |
UL | CL | 9153 |
1.10
|
1.07
|
1.12
| 995 |
1.12
|
1.05
|
1.19
| 10,148 |
1.10
|
1.08
|
1.12
|
CL | SL | 69 | 1.18 | 0.92 | 1.50 | 37 | 0.81 | 0.57 | 1.11 | 106 | 1.02 | 0.83 | 1.23 |
CL | UL | 995 |
1.12
|
1.05
|
1.20
| 9153 |
1.10
|
1.08
|
1.13
| 10,148 |
1.10
|
1.08
|
1.13
|