Skip to main content
Erschienen in:

01.09.2018 | Case Report

Fatal parvovirus B19 infections: a report of two autopsy cases

verfasst von: Hsuan-Yun Hu, Shyh-Yuh Wei, Wei-Hsiang Huang, Chih-Hsin Pan

Erschienen in: International Journal of Legal Medicine | Ausgabe 2/2019

Einloggen, um Zugang zu erhalten

Abstract

Parvovirus B19 (PVB19) commonly infects children and is usually asymptomatic. Lethal outcomes of PVB19 infection are unusual; nevertheless, the two cases reported here are rare examples of PVB19-induced hemophagocytic syndrome and myocarditis in infants and children. The two cases show the indisputable usefulness of immunohistochemistry and in situ hybridization in the detection of PVB19. In the death investigations, histopathological examinations provided stronger evidence than did serology or molecular biology. The cases also highlight the importance of forensic autopsy in vaccine-related death. As vaccine-related deaths are what people fear and may cause declines in vaccination rates, it is important to clarify deaths temporally or causally associated with vaccine administration.
Literatur
1.
Zurück zum Zitat Heegaard ED, Brown KE (2002) Human parvovirus B19. Clin Microbiol Rev 15:485–505CrossRef Heegaard ED, Brown KE (2002) Human parvovirus B19. Clin Microbiol Rev 15:485–505CrossRef
2.
Zurück zum Zitat Chorba T, Coccia P, Holman RC, Tattersall P, Anderson LJ, Sudman J, Young NS, Kurczynski E, Saarinen UM, Moir R, Lawrence DN, Jason JM, Evatt B (1986) The role of parvovirus B19 in aplastic crisis and erythema infectiosum (fifth disease). J Infect Dis 154:383–393CrossRef Chorba T, Coccia P, Holman RC, Tattersall P, Anderson LJ, Sudman J, Young NS, Kurczynski E, Saarinen UM, Moir R, Lawrence DN, Jason JM, Evatt B (1986) The role of parvovirus B19 in aplastic crisis and erythema infectiosum (fifth disease). J Infect Dis 154:383–393CrossRef
5.
Zurück zum Zitat Centers for Disease Control (CDC) (1989) Risks associated with human parvovirus B19 infection. MMWR Morb Mortal Wkly Rep 38:81–88 93–7 Centers for Disease Control (CDC) (1989) Risks associated with human parvovirus B19 infection. MMWR Morb Mortal Wkly Rep 38:81–88 93–7
6.
Zurück zum Zitat Kaya Z, Ozturk G, Gursel T, Bozdayi G (2005) Spontaneous resolution of hemophagocytic syndrome and disseminated intravascular coagulation associated with parvovirus b19 infection in a previously healthy child. Jpn J Infect Dis 58:149–151PubMed Kaya Z, Ozturk G, Gursel T, Bozdayi G (2005) Spontaneous resolution of hemophagocytic syndrome and disseminated intravascular coagulation associated with parvovirus b19 infection in a previously healthy child. Jpn J Infect Dis 58:149–151PubMed
12.
Zurück zum Zitat Saint-Martin J, Choulot JJ, Bonnaud E, Morinet F (1990) Myocarditis caused by parvovirus. J Pediatr 116:1007–1008CrossRef Saint-Martin J, Choulot JJ, Bonnaud E, Morinet F (1990) Myocarditis caused by parvovirus. J Pediatr 116:1007–1008CrossRef
13.
Zurück zum Zitat Saint-Martin J, Bonnaud E, Morinet F, Choulot JJ, Mensire A (1991) Acute parvovirus myocarditis with fatal outcome. Pediatrie 46:597–599PubMed Saint-Martin J, Bonnaud E, Morinet F, Choulot JJ, Mensire A (1991) Acute parvovirus myocarditis with fatal outcome. Pediatrie 46:597–599PubMed
14.
Zurück zum Zitat Orth T, Herr W, Spahn T et al (1997) Human parvovirus B19 infection associated with severe acute perimyocarditis in a 34-year-old man. Eur Heart J 18:524–525CrossRef Orth T, Herr W, Spahn T et al (1997) Human parvovirus B19 infection associated with severe acute perimyocarditis in a 34-year-old man. Eur Heart J 18:524–525CrossRef
19.
Zurück zum Zitat Enders G, Dotsch J, Bauer J, Nutzenadel W, Hengel H, Haffner D, Schalasta G, Searle K, Brown KE (1998) Life-threatening parvovirus B19-associated myocarditis and cardiac transplantation as possible therapy: two case reports. Clin Infect Dis 26:355–358CrossRef Enders G, Dotsch J, Bauer J, Nutzenadel W, Hengel H, Haffner D, Schalasta G, Searle K, Brown KE (1998) Life-threatening parvovirus B19-associated myocarditis and cardiac transplantation as possible therapy: two case reports. Clin Infect Dis 26:355–358CrossRef
20.
Zurück zum Zitat Beghetti M, Gervaix A, Haenggeli CA, Berner M, Rimensberger PC (2000) Myocarditis associated with parvovirus B19 infection in two siblings with merosin-deficient congenital muscular dystrophy. Eur J Pediatr 159:135–136CrossRef Beghetti M, Gervaix A, Haenggeli CA, Berner M, Rimensberger PC (2000) Myocarditis associated with parvovirus B19 infection in two siblings with merosin-deficient congenital muscular dystrophy. Eur J Pediatr 159:135–136CrossRef
23.
Zurück zum Zitat Dettmeyer R, Kandolf R, Baasner A, Banaschak S, Eis-Hubinger AM, Madea B (2003) Fatal parvovirus B19 myocarditis in an 8-year-old boy. J Forensic Sci 48:183–186PubMed Dettmeyer R, Kandolf R, Baasner A, Banaschak S, Eis-Hubinger AM, Madea B (2003) Fatal parvovirus B19 myocarditis in an 8-year-old boy. J Forensic Sci 48:183–186PubMed
24.
Zurück zum Zitat Respondek M, Bratosiewicz J, Pertynski T, Liberski PP (1997) Parvovirus particles in a fetal-heart with myocarditis: ultrastructural and immunohistochemical study. Arch Immunol Ther Exp 45:465–470 Respondek M, Bratosiewicz J, Pertynski T, Liberski PP (1997) Parvovirus particles in a fetal-heart with myocarditis: ultrastructural and immunohistochemical study. Arch Immunol Ther Exp 45:465–470
31.
32.
Zurück zum Zitat Uike N, Miyamura T, Obama K, Takahira H, Sato H, Kozuru M (1993) Parvovirus B19-associated haemophagocytosis in Evans syndrome: aplastic crisis accompanied by severe thrombocytopenia. Br J Haematol 84:530–532CrossRef Uike N, Miyamura T, Obama K, Takahira H, Sato H, Kozuru M (1993) Parvovirus B19-associated haemophagocytosis in Evans syndrome: aplastic crisis accompanied by severe thrombocytopenia. Br J Haematol 84:530–532CrossRef
33.
Zurück zum Zitat Shirono K, Tsuda H (1995) Parvovirus B19-associated haemophagocytic syndrome in healthy adults. Br J Haematol 89:923–926CrossRef Shirono K, Tsuda H (1995) Parvovirus B19-associated haemophagocytic syndrome in healthy adults. Br J Haematol 89:923–926CrossRef
34.
Zurück zum Zitat Matsumoto Y, Naniwa D, Banno S, Sugiura Y (1998) The efficacy of therapeutic plasmapheresis for the treatment of fatal hemophagocytic syndrome: two case reports. Ther Apher 2:300–304CrossRef Matsumoto Y, Naniwa D, Banno S, Sugiura Y (1998) The efficacy of therapeutic plasmapheresis for the treatment of fatal hemophagocytic syndrome: two case reports. Ther Apher 2:300–304CrossRef
35.
Zurück zum Zitat Chen JS, Lin KH, Lin DT, Chen RL, Jou ST, Su IJ (1998) Longitudinal observation and outcome of nonfamilial childhood haemophagocytic syndrome receiving etoposide-containing regimens. Br J Haematol 103:756–762CrossRef Chen JS, Lin KH, Lin DT, Chen RL, Jou ST, Su IJ (1998) Longitudinal observation and outcome of nonfamilial childhood haemophagocytic syndrome receiving etoposide-containing regimens. Br J Haematol 103:756–762CrossRef
36.
Zurück zum Zitat Imashuku S, Hibi S, Ohara T, Iwai A, Sako M, Kato M, Arakawa H, Sotomatsu M, Kataoka S, Asami K, Hasegawa D, Kosaka Y, Sano K, Igarashi N, Maruhashi K, Ichimi R, Kawasaki H, Maeda N, Tanizawa A, Arai K, Abe T, Hisakawa H, Miyashita H, Henter JI (1999) Effective control of Epstein-Barr virus-related hemophagocytic lymphohistiocytosis with immunochemotherapy. Histiocyte Society Blood 93:1869–1874PubMed Imashuku S, Hibi S, Ohara T, Iwai A, Sako M, Kato M, Arakawa H, Sotomatsu M, Kataoka S, Asami K, Hasegawa D, Kosaka Y, Sano K, Igarashi N, Maruhashi K, Ichimi R, Kawasaki H, Maeda N, Tanizawa A, Arai K, Abe T, Hisakawa H, Miyashita H, Henter JI (1999) Effective control of Epstein-Barr virus-related hemophagocytic lymphohistiocytosis with immunochemotherapy. Histiocyte Society Blood 93:1869–1874PubMed
37.
Zurück zum Zitat Estlin EJ, Palmer RD, Windebank KP, Lowry MF, Pearson AD (1996) Successful treatment of non-familial haemophagocytic lymphohistiocytosis with interferon and gammaglobulin. Arch Dis Child 75:432–435CrossRef Estlin EJ, Palmer RD, Windebank KP, Lowry MF, Pearson AD (1996) Successful treatment of non-familial haemophagocytic lymphohistiocytosis with interferon and gammaglobulin. Arch Dis Child 75:432–435CrossRef
38.
Zurück zum Zitat Lapphra K, Scheifele D (2011) Can children with minor illnesses be safely immunized? Paediatr Child Health 16:463 Lapphra K, Scheifele D (2011) Can children with minor illnesses be safely immunized? Paediatr Child Health 16:463
39.
Zurück zum Zitat Grohskopf LA, Sokolow LZ, Broder KR et al (2017) Prevention and control of seasonal influenza with vaccines: recommendations of the advisory committee on immunization practices - United States, 2017-18 influenza season. MMWR Recomm Rep 66:1–20 Grohskopf LA, Sokolow LZ, Broder KR et al (2017) Prevention and control of seasonal influenza with vaccines: recommendations of the advisory committee on immunization practices - United States, 2017-18 influenza season. MMWR Recomm Rep 66:1–20
Metadaten
Titel
Fatal parvovirus B19 infections: a report of two autopsy cases
verfasst von
Hsuan-Yun Hu
Shyh-Yuh Wei
Wei-Hsiang Huang
Chih-Hsin Pan
Publikationsdatum
01.09.2018
Verlag
Springer Berlin Heidelberg
Erschienen in
International Journal of Legal Medicine / Ausgabe 2/2019
Print ISSN: 0937-9827
Elektronische ISSN: 1437-1596
DOI
https://doi.org/10.1007/s00414-018-1921-6

Neu im Fachgebiet Rechtsmedizin

Pathologie der Milz

Nach einer Beschreibung der Milzanatomie und Darstellung der diagnostisch wichtigsten immunhistochemischen Färbungen zur Identifizierung der normalen Milzkompartimente werden am Beispiel eines nordafrikanischen Patienten mit rezentem …

Molekular definierte Nierenzellkarzinome 2025

Im Zuge der Überarbeitung der WHO-Klassifikation im Jahr 2022 konnten für mehrere Nierenzellkarzinome (NZK), die sich zuvor nicht eindeutig den bis dahin definierten Tumortypen zuordnen ließen, jedoch gemeinsame morphologische und molekulare …

Wichtige Änderungen in der WHO-Klassifikation der Hodentumoren 2022

In der 5. Auflage der „WHO-Klassifikation der Tumoren der ableitenden Harnwege und des männlichen Genitaltrakts“ sind bedeutende Anpassungen an den bisherigen Klassifikationen vorgenommen worden. Diese betreffen bei den Keimzelltumoren des Hodens …

DNA mixture deconvolution using fully continuous models EuroForMix and EFMrep

  • Open Access
  • Originalien

Mixture deconvolution is a powerful tool for inferring individual DNA profiles from DNA mixtures for subsequent transmission to a database or database queries. To carry out deconvolution, a mixed trace can be interpreted either manually by an …