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Erschienen in: European Archives of Psychiatry and Clinical Neuroscience 5/2014

01.08.2014 | Short Communication

Fatty acid ethanolamide levels are altered in borderline personality and complex posttraumatic stress disorders

verfasst von: Carola Schaefer, Frank Enning, Juliane K. Mueller, J. Malte Bumb, Cathrin Rohleder, Thorsten M. Odorfer, Joachim Klosterkötter, Martin Hellmich, Dagmar Koethe, Christian Schmahl, Martin Bohus, F. Markus Leweke

Erschienen in: European Archives of Psychiatry and Clinical Neuroscience | Ausgabe 5/2014

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Abstract

Borderline personality (BPD) and complex posttraumatic stress disorders (PTSD) are both powerfully associated with the experience of interpersonal violence during childhood and adolescence. The disorders frequently co-occur and often result in pervasive problems in, e.g., emotion regulation and altered pain perception, where the endocannabinoid system is deeply involved. We hypothesize an endocannabinoid role in both disorders. We investigated serum levels of the endocannabinoids anandamide and 2-arachidonoylglycerol and related fatty acid ethanolamides (FAEs) in BPD, PTSD, and controls. Significant alterations were found for both endocannabinoids in BPD and for the FAE oleoylethanolamide in PTSD suggesting a respective link to both disorders.
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Metadaten
Titel
Fatty acid ethanolamide levels are altered in borderline personality and complex posttraumatic stress disorders
verfasst von
Carola Schaefer
Frank Enning
Juliane K. Mueller
J. Malte Bumb
Cathrin Rohleder
Thorsten M. Odorfer
Joachim Klosterkötter
Martin Hellmich
Dagmar Koethe
Christian Schmahl
Martin Bohus
F. Markus Leweke
Publikationsdatum
01.08.2014
Verlag
Springer Berlin Heidelberg
Erschienen in
European Archives of Psychiatry and Clinical Neuroscience / Ausgabe 5/2014
Print ISSN: 0940-1334
Elektronische ISSN: 1433-8491
DOI
https://doi.org/10.1007/s00406-013-0470-8

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