Background
Methods
Patient selection
Patient no. | Age (years) | T stage | N Stage | Tumour size (mm) | HR | HER2 | SBR | Treatment side | Tumour location | Sequential adjuvant chemotherapy | Sequential adjuvant hormone therapy | Concomitant treatment | Specific clinical features | |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | 70 | pT1c | pN0 | 19 | + | - | 1 | Right | Inferior Junction | No | Exemestane | No | Cardiovascular disease | |
2 | 74 | pT1c | pN1mi | 13 | + | + | 2 | Left | Central | No | Exemestane | No | Cardiovascular disease | Chronic respiratory insufficiency |
3 | 72 | pT1b | pN0 | 9 | + | - | 1 | Left | SI | No | Letrozole | No | No | |
4 | 67 | pT1c | pN0 | 14 | + | - | 2 | Right | Superior Junction | No | Tamoxifen | No | No | |
5 | 78 | pT1a | pN0 | 3 | + | - | 2 | Right | SE | No | No | No | No | |
6 | 44 | pT1c | pN0 | 15 | + | + | 3 | Right | SE | No | Letrozole | No | Major scoliosis | Chronic respiratory insufficiency |
7 (right) | 74 | pT1c | pN0 | 17 | + | - | 1 | Right | SI | No | Anastrozole | No | Chronic respiratory insufficiency | |
7 (left) | 74 | pT1c | pN0 | 19 | + | - | 2 | Left | II | No | Anastrozole | No | Chronic respiratory insufficiency | |
8 | 76 | pT1b | pN0 | 9 | + | - | 2 | Left | SE | No | Tamoxifen | No | No | |
9 | 85 | pT1c | pN0 | 17 | + | - | 2 | Left | SE | No | No | No | No |
Acquisition and simulation
Contouring and volume definition
Treatment planning using RapidArc®
Dose prescription, dose constraints, dosimetric evaluation and dose delivery
Toxicity assessment
Results
Treatment planning
Mean value | Range [min-max] | |
---|---|---|
Ipsilateral breast (%) | ||
V50%
| 25.8 | [13.3–37.8] |
V100%
| 10.9 | [5.6–18.9] |
Contralateral breast (Gy) | ||
maximal dose | 3.0 | [1.3–5.8] |
mean dose | 0.6 | [0.1–1.7] |
Heart (%) | ||
V5Gy
| 3.1 | [0.0–23.6] |
Ipsilateral lung (%) | ||
V5Gy
| 6.2 | [0.0–19.9] |
V10Gy
| 1.6 | [0.0–10.4] |
V20Gy
| 0.3 | [0.0–2.7] |
Contralateral lung (%) | ||
V5Gy
| 0.3 | [0.0–2.8] |
V10Gy
| 0.0 | |
V20Gy
| 0.0 |
Acute and late toxicity
Grade 0 | Grade 1 | |
---|---|---|
Acute toxicities | ||
Breast pain | 5 | 5 |
Breast oedema | 5 | 5 |
Erythema | 4 | 6 |
Dry desquamation | 9 | 1 |
Moist desquamation | 9 | 1 |
Radiation-induced pneumonitis | 10 | 0 |
Late toxicities | ||
Breast pain | 9 | 1 |
Breast oedema | 10 | 0 |
Telangiectasia | 10 | 0 |
Pigmentation | 10 | 0 |
Fibrosis | 7 | 3 |
Atrophy | 10 | 0 |
Radiation-induced pneumonitis | 10 | 0 |
Fat necrosis | 10 | 0 |