Feasibility of intravoxel incoherent motion in the assessment of tumor microvasculature and blood–brain barrier integrity: a case-based evaluation of gliomas
- 15.12.2021
- Research Article
Erschienen in:
- Verfasst von
- Andre Monteiro Paschoal
- Maria Clara Zanon Zotin
- Lucas Murilo da Costa
- Antonio Carlos dos Santos
- Renata Ferranti Leoni
Abstract
Objective
To evaluate the feasibility of intravoxel incoherent motion (IVIM) in assessing blood–brain barrier (BBB) integrity and microvasculature in tumoral tissue of glioma patients.
Methods
Images from 8 high-grade and 4 low-grade glioma patients were acquired on a 3 T MRI scanner. Acquisition protocol included pre- and post-contrast T1- and T2-weighted imaging, FLAIR, dynamic susceptibility contrast (DSC), and susceptibility-weighted imaging (SWI). In addition, IVIM was acquired with 15 b-values and fitted under the non-negative least square (NNLS) model to output the diffusion (D) and pseudo-diffusion (D*) coefficients, perfusion fraction (f), and f times D* (fD*) maps.
Results
IVIM perfusion-related maps were sensitive to (1) blood flow and perfusion alterations within the microvasculature of brain tumors, in agreement with intra-tumoral susceptibility signal (ITSS); (2) enhancing areas of BBB breakdown in agreement with DSC maps as well as areas of BBB abnormality that was not detected on DSC maps; (3) enhancing perfusion changes within edemas; (4) detecting early foci of increased perfusion within low-grade gliomas.
Conclusion
The results suggest IVIM may be a promising approach to delineate tumor extension and progression in size, and to predict histological grade, which are clinically relevant information that characterize tumors and guide therapeutic decisions in patients with glioma.
Anzeige
- Titel
- Feasibility of intravoxel incoherent motion in the assessment of tumor microvasculature and blood–brain barrier integrity: a case-based evaluation of gliomas
- Verfasst von
-
Andre Monteiro Paschoal
Maria Clara Zanon Zotin
Lucas Murilo da Costa
Antonio Carlos dos Santos
Renata Ferranti Leoni
- Publikationsdatum
- 15.12.2021
- Verlag
- Springer International Publishing
- Erschienen in
-
Magnetic Resonance Materials in Physics, Biology and Medicine / Ausgabe 1/2022
Print ISSN: 0968-5243
Elektronische ISSN: 1352-8661 - DOI
- https://doi.org/10.1007/s10334-021-00987-0
Dieser Inhalt ist nur sichtbar, wenn du eingeloggt bist und die entsprechende Berechtigung hast.
Dieser Inhalt ist nur sichtbar, wenn du eingeloggt bist und die entsprechende Berechtigung hast.
